INT87517

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 73
Total Number 75
Disease Relevance 37.35
Pain Relevance 3.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (LDLR) small molecule metabolic process (LDLR) plasma membrane (LDLR)
lipid metabolic process (LDLR) lysosome (LDLR)
Anatomy Link Frequency
plasma 7
liver 6
mononuclear cells 6
macrophages 3
blood 3
LDLR (Homo sapiens)
Pain Link Frequency Relevance Heat
Restless leg syndrome 7 99.88 Very High Very High Very High
addiction 3 99.22 Very High Very High Very High
endometriosis 87 99.16 Very High Very High Very High
rheumatoid arthritis 219 97.44 Very High Very High Very High
tolerance 36 96.12 Very High Very High Very High
Sciatica 4 94.80 High High
Inflammation 204 90.96 High High
cytokine 97 87.40 High High
Angina 60 82.32 Quite High
Bile 90 80.56 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 1017 100.00 Very High Very High Very High
Hypertension 166 99.96 Very High Very High Very High
Myocardial Infarction 165 99.96 Very High Very High Very High
Increased Venous Pressure Under Development 256 99.88 Very High Very High Very High
Allergic Dermatitis 3 99.84 Very High Very High Very High
Hyperlipidemia 125 99.46 Very High Very High Very High
Metabolic Syndrome 141 99.36 Very High Very High Very High
Arteriosclerosis Obliterans 4 99.32 Very High Very High Very High
Weight Loss 42 99.20 Very High Very High Very High
Endometriosis (extended) 136 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus we were not expecting an effect on LDL receptor or HMG-CoA reductase expression due to treatment [8].


Gene_expression (expression) of LDL receptor
1) Confidence 0.69 Published 2006 Journal Lipids Health Dis Section Body Doc Link PMC1564017 Disease Relevance 0.09 Pain Relevance 0.08
The purpose of this study was to evaluate the relationship between liver and mononuclear cell expression of HMG-CoA reductase and the LDL receptor in guinea pigs, a well established model for human cholesterol and lipoprotein metabolism.
Gene_expression (expression) of LDL receptor in mononuclear cell
2) Confidence 0.69 Published 2006 Journal Lipids Health Dis Section Abstract Doc Link PMC1564017 Disease Relevance 0 Pain Relevance 0
Validation of using gene expression in mononuclear cells as a marker for hepatic cholesterol metabolism

HMG-CoA reductase and the LDL receptor are ubiquitously expressed in major tissues.

Gene_expression (expressed) of LDL receptor in mononuclear cells
3) Confidence 0.69 Published 2006 Journal Lipids Health Dis Section Title Doc Link PMC1564017 Disease Relevance 0 Pain Relevance 0
Also in our second project: the Israel Blood Pressure Control (IBPC) program [10], there was a significant increase in the percentage of patents defined as "controlled" in hypertension, Low Density Lipoprotein (LDL) levels and in the percentage of patients with diabetes.
Gene_expression (levels) of Low Density Lipoprotein in Blood associated with diabetes mellitus and hypertension
4) Confidence 0.67 Published 2007 Journal Cost Eff Resour Alloc Section Body Doc Link PMC2217271 Disease Relevance 1.24 Pain Relevance 0.07
We have recognized marked effectiveness for intermittent claudication with low-density lipoprotein (LDL) apheresis in two cases of arteriosclerosis obliterans (ASO).
Gene_expression (apheresis) of low-density lipoprotein associated with arteriosclerosis obliterans and restless leg syndrome
5) Confidence 0.64 Published 2007 Journal J Clin Apher Section Abstract Doc Link 17610290 Disease Relevance 0.59 Pain Relevance 0.25
HMG-CoA: 3-hydroxy-3methyl glutaryl Coenzyme A; LDL-C: LDL cholesterol; RCT: reverse cholesterol transport

Competing interests

Gene_expression (hydroxy) of LDL cholesterol
6) Confidence 0.60 Published 2006 Journal Lipids Health Dis Section Body Doc Link PMC1564017 Disease Relevance 0.08 Pain Relevance 0
In addition, previous studies in our laboratory have shown that the decreases in LDL-C observed following a weight reduction program were correlated with increased expression of the LDL receptor in human mononuclear cells [5].
Gene_expression (expression) of LDL receptor in mononuclear cells associated with weight loss
7) Confidence 0.54 Published 2006 Journal Lipids Health Dis Section Body Doc Link PMC1564017 Disease Relevance 0.10 Pain Relevance 0
The positive correlation found between the expression of the LDL receptor and HMG-CoA reductase in liver and mononuclear cells in the current study supports the measurement of the expression of these two ubiquitously distributed proteins in human mononuclear cells as a surrogate for hepatic cholesterol metabolism.


Gene_expression (expression) of LDL receptor in mononuclear cells
8) Confidence 0.54 Published 2006 Journal Lipids Health Dis Section Body Doc Link PMC1564017 Disease Relevance 0.09 Pain Relevance 0
These correlations suggest that monocytes can be used in humans as an index for liver to assess diet and drug effects on the expression of HMG-CoA reductase and the LDL receptor.



Gene_expression (expression) of LDL receptor in monocytes
9) Confidence 0.54 Published 2006 Journal Lipids Health Dis Section Abstract Doc Link PMC1564017 Disease Relevance 0 Pain Relevance 0
In agreement with the finding of no changes in plasma LDL-C, there were also no differences for the expression of HMG-CoA reductase or the LDL receptor among groups.
Gene_expression (expression) of LDL receptor in plasma
10) Confidence 0.54 Published 2006 Journal Lipids Health Dis Section Abstract Doc Link PMC1564017 Disease Relevance 0 Pain Relevance 0
The current study provided an opportunity to study gene expression in both liver and mononuclear cells to validate mononuclear cells as surrogates of hepatic expression of HMG-CoA reductase and the LDL receptor.
Gene_expression (expression) of LDL receptor in mononuclear cells
11) Confidence 0.54 Published 2006 Journal Lipids Health Dis Section Body Doc Link PMC1564017 Disease Relevance 0 Pain Relevance 0
In agreement with these data, there were no significant differences in the expression of the LDL receptor or HMG-CoA reductase among groups.
Gene_expression (expression) of LDL receptor
12) Confidence 0.54 Published 2006 Journal Lipids Health Dis Section Body Doc Link PMC1564017 Disease Relevance 0 Pain Relevance 0
The expression of LDL receptor in liver and mononuclear cells were also positively correlated (r = 0.623, P < 0.01) (Figure 1, Panel B).


Gene_expression (expression) of LDL receptor in liver
13) Confidence 0.54 Published 2006 Journal Lipids Health Dis Section Body Doc Link PMC1564017 Disease Relevance 0 Pain Relevance 0
The selective inhibition method was used to measure the level of high density lipoprotein cholesterol (HDL-C), and a homogeneous enzymatic calorimetric test was used to measure the level of low density lipoprotein cholesterol (LDL-C) (Advia 1650 Autoanalyzer; Byer Diagnostics, Leverkusen, Germany).
Gene_expression (level) of low density lipoprotein associated with disorder of lipid metabolism
14) Confidence 0.49 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2972488 Disease Relevance 0.60 Pain Relevance 0
Expression of mRNA for the LDLr and LRP in THP-1 macrophages
Gene_expression (Expression) of LDLr in macrophages
15) Confidence 0.47 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC1906864 Disease Relevance 0.20 Pain Relevance 0
It is conceivable that more aggressive LDL-cholesterol reduction might further prevent atherosclerotic events.
Gene_expression (reduction) of LDL-cholesterol associated with atherosclerosis
16) Confidence 0.46 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788595 Disease Relevance 0.82 Pain Relevance 0
The importance of treating abnormal lipid concentrations to prevent atherosclerotic events is also reflected in the guidelines of professional associations such as the American Heart Assocation, European Society of Cardiology and others.5,6 These guidelines have focused on LDL-cholesterol reduction although over the last decade it has been recognized that triglycerides, high-density lipoprotein (HDL)-cholesterol, and lipoprotein(a) are not only important as predictors of atherosclerotic events but are potential therapeutic targets.7 This is very important since LDL-lowering strategies can obviously not prevent all atherosclerotic events.
Gene_expression (reduction) of LDL-cholesterol in Heart associated with atherosclerosis and disorder of lipid metabolism
17) Confidence 0.46 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788595 Disease Relevance 0.82 Pain Relevance 0
In patients with normal triglyceride and HDL-cholesterol levels but elevated LDL-cholesterol levels despite statin therapy several approaches are possible.
Gene_expression (levels) of LDL-cholesterol associated with disorder of lipid metabolism
18) Confidence 0.46 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788595 Disease Relevance 0.41 Pain Relevance 0.04
Apart from fibrinogen (Clauss method), total cholesterol, LDL-cholesterol (calculated) and HDL-cholesterol (precipitation method) levels, triglycerides (non-fasting), creati-nine and alkaline phosphate were also measured, alkaline phosphatase providing a measure of compliance with treatment.
Gene_expression (measured) of LDL-cholesterol associated with disorder of lipid metabolism
19) Confidence 0.46 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC57751 Disease Relevance 0.56 Pain Relevance 0.07
Since two receptors for LDL, namely apolipoprotein B specific 'low density lipoprotein receptor (LDLR)' and LDL-cholesterol specific 'Receptor Ck' are present on cells, we wanted to confirm that the observed effect on the transcription of hTERT, c-myc and PPAR?
Gene_expression (present) of LDL-cholesterol associated with disorder of lipid metabolism
20) Confidence 0.46 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.10 Pain Relevance 0

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