INT87528

Context Info Confidence 0.41 First Reported 2000 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0 Pain Relevance 0

cytosol (PSMC6) nucleoplasm (PSMC6) small molecule metabolic process (PSMC6) ATPase activity (PSMC6) nucleus (PSMC6) protein binding, bridging (PSMC6)

PSMC6 (Homo sapiens)

Pain Link Frequency Relevance Heat Enkephalin 1 25.00 Neuropeptide 1 25.00 Chronic pancreatitis 1 5.00

Disease Link Frequency Relevance Heat Nicotine Addiction 2 5.00 Adenocarcinoma 2 5.00 Pancreatitis 1 5.00 Pancreatic Cancer 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In dissociated astroglial cells, inhibition of protein kinase A, of p44,42 mitogen-activated protein kinase as well as of the EGF-receptor tyrosine kinase by H89, PD98059 and AG1478, respectively, reduced the PACAP38-induced expression in a synergistic manner.

Negative_regulation (inhibition) of p44

1) Confidence 0.41 Published 2000 Journal Glia Section Abstract Doc Link 10756074 Disease Relevance 0 Pain Relevance 0

This response was inhibited by the adenylyl cyclase, protein kinase A, mitogen-activated protein kinase (p42/p44), and epidermal growth factor receptor-specific tyrosine kinase inhibitors.

Negative_regulation (inhibitors) of p44

2) Confidence 0.18 Published 2006 Journal Pancreas Section Body Doc Link 16804413 Disease Relevance 0 Pain Relevance 0

General Comments

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