INT87546

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Context Info
Confidence 0.71
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 7.49
Pain Relevance 7.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gdnf) extracellular space (Gdnf) extracellular region (Gdnf)
Anatomy Link Frequency
spinal 2
spinal cord 2
neuronal 1
dorsal 1
neurons 1
Gdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 121 99.56 Very High Very High Very High
Endep 17 99.48 Very High Very High Very High
spinal dorsal horn 5 99.36 Very High Very High Very High
antidepressant 55 99.30 Very High Very High Very High
Eae 5 97.96 Very High Very High Very High
Neuropathic pain 21 97.88 Very High Very High Very High
Thermal hyperalgesia 2 97.36 Very High Very High Very High
Nerve growth factor 2 96.64 Very High Very High Very High
Lasting pain 4 96.00 Very High Very High Very High
Neurotransmitter 4 95.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 7 100.00 Very High Very High Very High
Convulsion 11 99.36 Very High Very High Very High
Substance Withdrawal Syndrome 1 98.64 Very High Very High Very High
Arthritis 4 98.52 Very High Very High Very High
Injury 107 98.44 Very High Very High Very High
Glioblastoma 4 98.12 Very High Very High Very High
Neuropathic Pain 21 97.88 Very High Very High Very High
Hyperalgesia 7 97.36 Very High Very High Very High
Spinal Cord Injury 56 97.04 Very High Very High Very High
Pain 8 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present work demonstrated a down-regulation of glial cell line-derived neurotrophic factor (GDNF) mRNA expression in dorsal spinal cord in complete Freund's adjuvant-induced unilateral arthritic rats serving as a chronic pain model.
Transcription (expression) of GDNF in spinal cord associated with lasting pain, arthritis and spinal cord
1) Confidence 0.71 Published 2000 Journal Neuroreport Section Abstract Doc Link 10757511 Disease Relevance 0.62 Pain Relevance 0.71
In the rostral stump, strong GDNF IR was detected in neurons from the ventral horn at 3 and 7 dpo (c, e, 400×, arrows).
Transcription (detected) of GDNF in ventral
2) Confidence 0.69 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0 Pain Relevance 0.08
The results showed that both protein and mRNA levels of GDNF and GFRalpha-1 in the dorsal root ganglions (DRG), as well as GDNF protein in the spinal dorsal horn, were significantly increased after chronic constriction injury (CCI) of the rats' sciatic nerve and could be further enhanced by EA treatment.
Transcription (levels) of GDNF in spinal associated with ganglion cysts, eae, spinal dorsal horn, injury, sciatic nerve and electroacupuncture
3) Confidence 0.68 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15698937 Disease Relevance 0.83 Pain Relevance 1.24
The results showed that both protein and mRNA levels of GDNF and GFRalpha-1 in the dorsal root ganglions (DRG), as well as GDNF protein in the spinal dorsal horn, were significantly increased after chronic constriction injury (CCI) of the rats' sciatic nerve and could be further enhanced by EA treatment.
Transcription (levels) of GDNF in spinal associated with ganglion cysts, eae, spinal dorsal horn, injury, sciatic nerve and electroacupuncture
4) Confidence 0.65 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15698937 Disease Relevance 0.84 Pain Relevance 1.26
Satake et al. [42] reported GDNF transcription began to increase within 30 min after injury and peaked within 3 h after spinal cord contusion injury.
Transcription (transcription) of GDNF in spinal cord associated with injury and spinal cord
5) Confidence 0.62 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0.66 Pain Relevance 0.16
Moreover, a significant increase in the expression of mRNA for IL-1beta, GDNF and iNOS were observed 6h following the HFS conditioning (p<0.05, HFS vs. control).
Transcription (expression) of GDNF
6) Confidence 0.59 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19596210 Disease Relevance 0.25 Pain Relevance 0.82
It has been shown that GDNF mRNAs widely distributed in a variety of neuronal and non-neuronal tissues of embryos and adults [4, 23–25].
Transcription (distributed) of GDNF in neuronal
7) Confidence 0.53 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0.47 Pain Relevance 0.11
Decreased GDNF mRNA expression in dorsal spinal cord of unilateral arthritic rat.
Transcription (expression) of GDNF in dorsal associated with arthritis and spinal cord
8) Confidence 0.53 Published 2000 Journal Neuroreport Section Title Doc Link 10757511 Disease Relevance 0.61 Pain Relevance 0.68
Amitriptyline treatment also increased GDNF mRNA expression in rat astrocytes.
Transcription (expression) of GDNF in astrocytes associated with endep
9) Confidence 0.52 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11595754 Disease Relevance 0.17 Pain Relevance 0.55
Here, we demonstrated that long-term use of antidepressant treatment significantly increased GDNF mRNA expression and GDNF release in time- and concentration-dependent manners in rat C6 glioblastoma cells.
Transcription (expression) of GDNF associated with antidepressant and glioblastoma
10) Confidence 0.52 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11595754 Disease Relevance 0.17 Pain Relevance 0.51
The results showed that both the protein and mRNA levels of GDNF and GFRalpha-1 were significantly increased after CCI, while the thermal hyperalgesia of neuropathic pain rats could be significantly aggravated by antisense ODN treatment, but not by normal saline (NS) or mismatch ODN treatment.
Transcription (levels) of GDNF associated with thermal hyperalgesia, eae and neuropathic pain
11) Confidence 0.49 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16289634 Disease Relevance 1.33 Pain Relevance 1.01
METHODS: The levels of GDNF, GDNFR-alpha and GDNFR-beta mRNA were assayed by reverse transcription polymerase chain reaction (RT-PCR) with the beta-actin mRNA as an internal control.
Transcription (levels) of GDNF in internal
12) Confidence 0.49 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 11798749 Disease Relevance 0.19 Pain Relevance 0
Our results also supported the mRNA expression for GDNF in neurons of the ventral horn, as well as astrocytes in white matter using in situ hybridization.
Transcription (expression) of GDNF in neurons
13) Confidence 0.46 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0.43 Pain Relevance 0.04
Levels of GDNF and RET mRNAs were not significantly changed following either acute or chronic ECS treatment at the time points examined.
Transcription (Levels) of GDNF associated with convulsion
14) Confidence 0.43 Published 2001 Journal Synapse Section Abstract Doc Link 11071708 Disease Relevance 0.86 Pain Relevance 0.27
Figures 2 A, B show that NGF, NT-3, GDNF and BDNF transcription increased continuously over the 14 day cultivation period upon PMA treatment, while bFGF, CNTF and Creb showed a steady decline, but these changes were compensatory modulated by antidepressant drugs (Figure 2C–F).
Transcription (transcription) of GDNF associated with antidepressant
15) Confidence 0.15 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2275236 Disease Relevance 0.06 Pain Relevance 0.35

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