INT87548

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Context Info
Confidence 0.54
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 5.67
Pain Relevance 5.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gdnf) extracellular space (Gdnf) extracellular region (Gdnf)
Anatomy Link Frequency
dorsal 2
CSF 2
spinal cord 2
brainstem 2
DRGs 2
Gdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 7 99.80 Very High Very High Very High
Spinal cord 38 99.56 Very High Very High Very High
Migraine 20 98.96 Very High Very High Very High
headache 8 98.44 Very High Very High Very High
Sciatic nerve 4 98.36 Very High Very High Very High
Neurotransmitter 3 98.20 Very High Very High Very High
Neuropathic pain 8 97.84 Very High Very High Very High
Nerve growth factor 110 97.68 Very High Very High Very High
Pain 9 97.00 Very High Very High Very High
central sensitization 1 96.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Headache 26 98.96 Very High Very High Very High
Arthritis 4 98.52 Very High Very High Very High
Neuropathic Pain 11 97.84 Very High Very High Very High
Disease 2 97.72 Very High Very High Very High
Injury 51 97.52 Very High Very High Very High
Pain 12 97.00 Very High Very High Very High
Fibromyalgia 6 96.36 Very High Very High Very High
Ganglion Cysts 73 96.24 Very High Very High Very High
Apoptosis 3 95.80 Very High Very High Very High
INFLAMMATION 8 94.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expressions of both GDNF and GDNFR-alpha in the frontal cortex were decreased by treatment with MK801 (0.5 mg/kg), and the expressions of GDNF in both the stem and cortex, and GDNFR-beta in the brainstem decreased by treatment with the methyl-scopolamine (0.5 mg/kg).
Negative_regulation (decreased) of Gene_expression (expressions) of GDNF in brainstem
1) Confidence 0.54 Published 2000 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 11798749 Disease Relevance 0.12 Pain Relevance 0
The present results suggest that decreased expression of GDNF takes some part in development and/or maintenance of neuropathic pain.
Negative_regulation (decreased) of Gene_expression (expression) of GDNF associated with neuropathic pain
2) Confidence 0.49 Published 2003 Journal J. Med. Dent. Sci. Section Abstract Doc Link 12715924 Disease Relevance 0.58 Pain Relevance 0.68
The present work demonstrated a down-regulation of glial cell line-derived neurotrophic factor (GDNF) mRNA expression in dorsal spinal cord in complete Freund's adjuvant-induced unilateral arthritic rats serving as a chronic pain model.
Negative_regulation (down-regulation) of Gene_expression (expression) of GDNF in spinal cord associated with lasting pain, arthritis and spinal cord
3) Confidence 0.43 Published 2000 Journal Neuroreport Section Abstract Doc Link 10757511 Disease Relevance 0.63 Pain Relevance 0.72
For detection of GDNF cellular expression in situ, we used Digoxigenin-labeled oligonucleotide probe designed by Primer premier 5.0 package which was complementary to the rats GDNF gene sequence (33 mer, 5?
Negative_regulation (detection) of Gene_expression (expression) of GDNF
4) Confidence 0.43 Published 2007 Journal Neurochem Res Section Body Doc Link PMC2270371 Disease Relevance 0.27 Pain Relevance 0.19
Decreased GDNF mRNA expression in dorsal spinal cord of unilateral arthritic rat.
Negative_regulation (Decreased) of Gene_expression (expression) of GDNF in dorsal associated with arthritis and spinal cord
5) Confidence 0.42 Published 2000 Journal Neuroreport Section Title Doc Link 10757511 Disease Relevance 0.61 Pain Relevance 0.68
Accompanied by the behavioral changes, expression of GDNF decreased in the dorsal root ganglia (DRGs) and the sciatic nerve on the injured side on the fourteenth day after the surgery.
Negative_regulation (decreased) of Gene_expression (expression) of GDNF in DRGs associated with sciatic nerve
6) Confidence 0.36 Published 2003 Journal J. Med. Dent. Sci. Section Abstract Doc Link 12715924 Disease Relevance 0.54 Pain Relevance 0.70
RESULTS: Intrathecal application of GDNF stimulates expression of somatostatin, a neuropeptide with potential analgesic properties.
Negative_regulation (application) of Gene_expression (expression) of GDNF
7) Confidence 0.34 Published 2009 Journal Pain Med Section Body Doc Link 19818033 Disease Relevance 0 Pain Relevance 0
GDNF is protective against the loss of dopaminergic neurons in animal models of Parkinson's disease [52,53], and GDNF reduces the number of apoptotic bodies in DRG explants from adult mice [54].
Negative_regulation (loss) of Gene_expression (protective) of GDNF in dopaminergic neurons associated with dorsal root ganglion, apoptosis and disease
8) Confidence 0.19 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.84 Pain Relevance 0.39
Based on experimental findings, it can be postulated that reduced CSF levels of GDNF and somatostatin in both CM and PCM + PAAH patients can contribute to sustained central sensitization underlying chronic head pain.
Negative_regulation (reduced) of Gene_expression (levels) of GDNF in CSF associated with central sensitization, migraine, somatostatin and headache
9) Confidence 0.14 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16556241 Disease Relevance 2.09 Pain Relevance 2.57

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