INT87549

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Context Info
Confidence 0.35
First Reported 2000
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.12
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Vps45) vesicle-mediated transport (Vps45) Golgi apparatus (Vps45)
cellular_component (Vps45) biological_process (Vps45)
Anatomy Link Frequency
TMJ 2
Vsp 1
Vps45 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 15 99.70 Very High Very High Very High
Snapping jaw 14 99.44 Very High Very High Very High
parabrachial 2 94.04 High High
Spinal cord 5 93.04 High High
antagonist 3 78.24 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 13 99.70 Very High Very High Very High
Temporomandibular Joint Syndrome 14 99.44 Very High Very High Very High
Nociception 3 97.36 Very High Very High Very High
Injury 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In inflamed rats, the percentage of trigemino- and paratrigeminoparabrachial neurons with up-regulation of PPD mRNA was significantly increased in the ipsilateral Vsp (5.7+/-1.8%) and Pa5 (22.8+/-7.4%, n = 3) when compared with the contralateral side and with saline-treated controls (p < 0.05).
Positive_regulation (increased) of Vsp in Vsp
1) Confidence 0.35 Published 2000 Journal Neuroreport Section Abstract Doc Link 10757531 Disease Relevance 0.50 Pain Relevance 0.55
These results suggest that the selective up-regulation of PPD mRNA in the Vsp and Pa5 following TMJ inflammation involves ascending trigeminal nociceptive pathways.
Positive_regulation (up-regulation) of Vsp in TMJ associated with nociception, snapping jaw and inflammation
2) Confidence 0.35 Published 2000 Journal Neuroreport Section Abstract Doc Link 10757531 Disease Relevance 0.75 Pain Relevance 0.54
TMJ inflammation alone did not induce a significant level of Fos-LI in the VSP.
Neg (not) Positive_regulation (induce) of VSP in TMJ associated with snapping jaw and inflammation
3) Confidence 0.12 Published 2006 Journal Neuroscience Section Abstract Doc Link 16979827 Disease Relevance 0.86 Pain Relevance 0.87

General Comments

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