INT8757

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Context Info
Confidence 0.48
First Reported 1992
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 5.84
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ACHE) extracellular space (ACHE) extracellular region (ACHE)
cell adhesion (ACHE) Golgi apparatus (ACHE) plasma membrane (ACHE)
Anatomy Link Frequency
neurons 1
cortex 1
ACHE (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid receptor 1 2 100.00 Very High Very High Very High
substance P 5 99.48 Very High Very High Very High
positron emission tomography 14 98.86 Very High Very High Very High
Enkephalin 8 98.84 Very High Very High Very High
Neuropeptide 8 97.20 Very High Very High Very High
Dynorphin 1 94.08 High High
Nucleus accumbens 3 91.76 High High
Nicotine 4 87.52 High High
antagonist 20 87.44 High High
Peripheral nervous system 2 81.44 Quite High
Disease Link Frequency Relevance Heat
Disease 425 98.96 Very High Very High Very High
Cerebrovascular Disease 5 95.84 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 3 95.68 Very High Very High Very High
Dementia 60 95.52 Very High Very High Very High
Aging 17 94.96 High High
Toxicity 21 91.88 High High
Respiratory Failure 16 86.88 High High
Cognitive Disorder 111 85.52 High High
Stroke 5 84.96 Quite High
Injury 3 84.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Possible interaction of acetylcholinesterase neurons and substance P and enkephalin fibers would commence by 15 weeks' gestation.
acetylcholinesterase Binding (interaction) of in neurons associated with enkephalin and substance p
1) Confidence 0.48 Published 1992 Journal Neuroscience Section Abstract Doc Link 1378580 Disease Relevance 0 Pain Relevance 0.63
Oximes, such as pralidoxime, can reactivate acetylcholinesterase but the ability to reverse acetylcholinesterase (AChE) inhibition with oximes varies with the type of pesticide ingested and time to treatment as both these factors affect the rate of enzyme ageing [8,9].
acetylcholinesterase Neg (inhibition) Binding (inhibition) of associated with aging
2) Confidence 0.37 Published 2009 Journal Trials Section Body Doc Link PMC2743678 Disease Relevance 0.77 Pain Relevance 0.04
Oximes, such as pralidoxime, can reactivate acetylcholinesterase but the ability to reverse acetylcholinesterase (AChE) inhibition with oximes varies with the type of pesticide ingested and time to treatment as both these factors affect the rate of enzyme ageing [8,9].
AChE Neg (inhibition) Binding (inhibition) of associated with aging
3) Confidence 0.37 Published 2009 Journal Trials Section Body Doc Link PMC2743678 Disease Relevance 0.76 Pain Relevance 0.04
The relationship of neuropeptide-containing cell clusters to the striosomal organization was characterized by looking at the register of these markers with patterns of low acetylcholinesterase activity and dense mu opiate receptor binding.
acetylcholinesterase Binding (binding) of associated with opioid receptor 1 and neuropeptide
4) Confidence 0.35 Published 1995 Journal Neuroscience Section Abstract Doc Link 7536307 Disease Relevance 0 Pain Relevance 0.50
Observational studies of pralidoxime and obidoxime suggest that the ability to reverse acetylcholinesterase inhibition with oximes varies with the pesticide ingested (figure 4).9,13,69,83 Acetylcholinesterase inhibited by diethyl pesticides, such as parathion and quinalphos, seems to be effectively reactivated by oximes, but acetylcholinesterase inhibited by dimethyl organophosphorus, such as monocrotophos or oxydemeton-methyl, seems to respond poorly.
acetylcholinesterase Neg (inhibition) Binding (inhibition) of
5) Confidence 0.34 Published 2008 Journal Lancet Section Body Doc Link PMC2493390 Disease Relevance 0.21 Pain Relevance 0
A major drawback of acetylcholinesterase assays is that the interaction between organophosphorus, acetylcholinesterase, and oximes continues if the sample is left at room temperature for even a few minutes (panel 2).
acetylcholinesterase Binding (interaction) of
6) Confidence 0.33 Published 2008 Journal Lancet Section Body Doc Link PMC2493390 Disease Relevance 0.12 Pain Relevance 0.03
It can be combined with acetylcholinesterase inhibitors which are the mainstay of current symptomatic treatment of Alzheimer's disease.
acetylcholinesterase Binding (combined) of associated with disease
7) Confidence 0.31 Published 2000 Journal Expert Opin Investig Drugs Section Abstract Doc Link 11060751 Disease Relevance 1.73 Pain Relevance 0.19
A PET study evaluated the effects of galantamine treatment on AChE and nicotinic receptor binding in 18 patients with mild AD over 12 months [68].
AChE Binding (binding) of associated with positron emission tomography and disease
8) Confidence 0.28 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866463 Disease Relevance 0.61 Pain Relevance 0.17
Cholinesterase inhibitors vary widely in their pharmacological profiles and affinities for AChE and butyrylcholinesterase.
AChE Binding (affinities) of
9) Confidence 0.27 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647161 Disease Relevance 0.11 Pain Relevance 0
The results show a modest inhibition of AChE with treatment that is most apparent in the cingulated cortex, and correlates with performance on tests of executive function and attention.
AChE Binding (inhibition) of in cortex associated with attention deficit hyperactivity disorder
10) Confidence 0.22 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866463 Disease Relevance 1.26 Pain Relevance 0.09
Lipocrine, a hybrid compound of tacrine and lipoic acid, blocks the catalytic binding site of acetylcholinesterase and ?
acetylcholinesterase Binding (site) of
11) Confidence 0.05 Published 2009 Journal The Open Neurology Journal Section Body Doc Link PMC2684708 Disease Relevance 0.27 Pain Relevance 0.03

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