INT87571

Context Info Confidence 0.41 First Reported 2000 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 6 Total Number 6 Disease Relevance 1.69 Pain Relevance 1.51

plasma membrane (KCNQ1) transmembrane transport (KCNQ1)

Anatomy Link Frequency myocytes 1 KCNQ1 (Homo sapiens)

Pain Link Frequency Relevance Heat addiction 7 98.68 action potential duration 20 98.24 Calcitonin gene-related peptide 4 97.72 qutenza 6 97.08 Action potential 52 87.80 potassium channel 10 84.84 Neuropathic pain 2 77.80 Spinal cord 4 69.72 Migraine 1 53.36 medulla 1 21.16

Disease Link Frequency Relevance Heat Stress 9 100.00 Injury 6 99.12 Neuropathic Pain 2 77.80 Epilepsy 6 76.96 Cognitive Disorder 2 74.20 Headache 1 53.36 Increased Venous Pressure Under Development 1 52.96 Cardiovascular Disorder Under Development 4 50.00 Syndrome 9 46.88 Heart Arrhythmia 1 11.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Flunarizine also inhibits KCNQ1/KCNE1 channel current with an IC50 of 0.76 microM.

Negative_regulation (inhibits) of KCNQ1

1) Confidence 0.41 Published 2006 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 16495758 Disease Relevance 0.16 Pain Relevance 0.19

In healthy tissues, full block of IKs failed to have a significant impact on the APD in ventricular myocytes of rabbits (only 4% mean prolongation in the presence of IKs blocker chromanol 293B (Lengyel et al. 2001)), dogs (a frequency-independent 7% increase with the same blocker (Varro et al. 2000)) and human myocytes (APD changes less than 12?

Negative_regulation (block) of IKs in myocytes associated with action potential duration

2) Confidence 0.32 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944395 Disease Relevance 0 Pain Relevance 0.29

Further, the compound enhanced the maximal current amplitude at all potentials for Kv7.4 and Kv7.5 whereas the combined activation/block of Kv7.2 and Kv7.2/3 was strongly voltage-dependent.

Negative_regulation (activation/block) of Kv7

3) Confidence 0.21 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16904708 Disease Relevance 0.23 Pain Relevance 0.19

Further, the compound enhanced the maximal current amplitude at all potentials for Kv7.4 and Kv7.5 whereas the combined activation/block of Kv7.2 and Kv7.2/3 was strongly voltage-dependent.

Negative_regulation (activation/block) of Kv7

4) Confidence 0.21 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16904708 Disease Relevance 0.23 Pain Relevance 0.19

Therefore, these motifs either evolved in an earlier KCNQ common ancestor gene, but were lost subsequently by evolution of KCNQ1, KCNQ4 and KCNQ5, or appeared first in a gene ancestral only to KCNQ2 and KCNQ3.

Negative_regulation (evolution) of KCNQ1

5) Confidence 0.17 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2597720 Disease Relevance 0 Pain Relevance 0.03

WRS alone caused a significant reduction (by 52% and -35%, respectively) in gastric and duodenal CGRP content, which was prevented by acute capsaicin treatment.

Negative_regulation (reduction) of WRS associated with stress, qutenza and calcitonin gene-related peptide

6) Confidence 0.05 Published 2000 Journal Dig. Dis. Sci. Section Abstract Doc Link 10759257 Disease Relevance 1.07 Pain Relevance 0.61

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