INT876

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Context Info
Confidence 0.80
First Reported 1975
Last Reported 2009
Negated 3
Speculated 11
Reported most in Abstract
Documents 843
Total Number 854
Disease Relevance 67.75
Pain Relevance 340.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh1) signal transduction (Gh1) mitochondrion (Gh1)
extracellular space (Gh1) extracellular region (Gh1) plasma membrane (Gh1)
Anatomy Link Frequency
pituitary 72
hypothalamus 35
plasma 21
brain 17
somatotropes 17
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 2583 99.98 Very High Very High Very High
Clonidine 1495 99.98 Very High Very High Very High
Opioid 369 99.98 Very High Very High Very High
opiate 328 99.98 Very High Very High Very High
Potency 148 99.96 Very High Very High Very High
Somatostatin 3499 99.94 Very High Very High Very High
antagonist 3982 99.92 Very High Very High Very High
substance P 1483 99.92 Very High Very High Very High
gABA 1412 99.92 Very High Very High Very High
Morphine 607 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 4460 100.00 Very High Very High Very High
Depression 208 99.92 Very High Very High Very High
Toxicity 3 99.92 Very High Very High Very High
INFLAMMATION 2649 99.84 Very High Very High Very High
Diabetes Mellitus 154 99.84 Very High Very High Very High
Cancer 2071 99.80 Very High Very High Very High
Hypotension 107 99.80 Very High Very High Very High
Thyroid Disease 378 99.74 Very High Very High Very High
Aging 171 99.72 Very High Very High Very High
Hyperglycemia 12 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of chronic stimulation or antagonism of opiate receptors on GH secretion in male and female rats.
Localization (secretion) of GH associated with narcan and opiate
1) Confidence 0.80 Published 1993 Journal Life Sci. Section Title Doc Link 8385257 Disease Relevance 0 Pain Relevance 0.73
These two changes resulted in a 3-fold increase in both mean GH concentration and total GH secretion over 6 h.
Localization (secretion) of GH
2) Confidence 0.80 Published 1993 Journal Life Sci. Section Abstract Doc Link 8385257 Disease Relevance 0 Pain Relevance 0.70
These data suggest that endogenous opioid systems are involved in the regulation of the basal GH secretion in both male and female rats.
Localization (secretion) of GH associated with endogenous opioid
3) Confidence 0.80 Published 1993 Journal Life Sci. Section Abstract Doc Link 8385257 Disease Relevance 0 Pain Relevance 0.64
The present study was undertaken to assess the role of endogenous opioid systems in the sexually dimorphic pattern of growth hormone (GH) secretion.
Localization (secretion) of GH associated with endogenous opioid
4) Confidence 0.80 Published 1993 Journal Life Sci. Section Abstract Doc Link 8385257 Disease Relevance 0 Pain Relevance 0.59
These two changes resulted in a 3-fold increase in both mean GH concentration and total GH secretion over 6 h.
Localization (secretion) of GH
5) Confidence 0.80 Published 1993 Journal Life Sci. Section Abstract Doc Link 8385257 Disease Relevance 0 Pain Relevance 0.69
In female rats, chronic morphine reduced GH pulse amplitudes but did not significantly affect other parameters of GH secretion.
Localization (secretion) of GH associated with morphine
6) Confidence 0.80 Published 1993 Journal Life Sci. Section Abstract Doc Link 8385257 Disease Relevance 0 Pain Relevance 0.68
Clonidine microinjection into the amygdala nucleus had no effect on GH release, while the injection into the preoptic and anterior hypothalamic area (PO/AH) significantly stimulated GH release by causing it to begin 30 min earlier.
Localization (release) of GH in anterior associated with amygdala and clonidine
7) Confidence 0.80 Published 1983 Journal Endocrinol. Jpn. Section Abstract Doc Link 6141046 Disease Relevance 0.09 Pain Relevance 0.38
Ten hr prior to the microinjection, alpha-methyl-p-tyrosine (250 mg/kg body weight) was intraperitoneally injected to prevent spontaneous pulsatile GH release.
Localization (release) of GH in body associated with body weight
8) Confidence 0.80 Published 1983 Journal Endocrinol. Jpn. Section Abstract Doc Link 6141046 Disease Relevance 0.10 Pain Relevance 0.38
In the area from the posterior hypothalamus to the mammillary body, several injections stimulated GH release (6/15), but the stimulatory effect was statistically insignificant when comparison was made with the mean (+/- SE) for all 15 rats.
Localization (release) of GH in hypothalamus
9) Confidence 0.80 Published 1983 Journal Endocrinol. Jpn. Section Abstract Doc Link 6141046 Disease Relevance 0.07 Pain Relevance 0.33
To determine the localization of the clonidine sensitive area responsible for GH release, a minute amount of the alpha 2-agonist (67 ng/0.2 microliter) was injected into the hypothalamus and vicinity of adult male conscious rats.
Localization (release) of GH in hypothalamus associated with agonist and clonidine
10) Confidence 0.80 Published 1983 Journal Endocrinol. Jpn. Section Abstract Doc Link 6141046 Disease Relevance 0.07 Pain Relevance 0.35
The results demonstrate that CS and GH secretions are able to manifest the same ultradian rhythms as those in the unanesthetized, freely moving condition even in the continuous-sleep state due to thiopental anesthesia.
Localization (secretions) of GH associated with anesthesia
11) Confidence 0.80 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3822076 Disease Relevance 0 Pain Relevance 0.24
These findings suggest that the alpha 2-agonist acts on the PO/AH to induce an increase in GH release in alpha-methyl-p-tyrosine-pretreated rats, probably mediating the inhibitory input to somatostatinergic neurons which reside in the periventricular nucleus of the PO/AH area.
Localization (release) of GH in neurons associated with agonist
12) Confidence 0.80 Published 1983 Journal Endocrinol. Jpn. Section Abstract Doc Link 6141046 Disease Relevance 0.06 Pain Relevance 0.24
Clonidine microinjection into the amygdala nucleus had no effect on GH release, while the injection into the preoptic and anterior hypothalamic area (PO/AH) significantly stimulated GH release by causing it to begin 30 min earlier.
Localization (release) of GH in anterior associated with amygdala and clonidine
13) Confidence 0.80 Published 1983 Journal Endocrinol. Jpn. Section Abstract Doc Link 6141046 Disease Relevance 0.09 Pain Relevance 0.39
The present experiments were aimed at testing whether an interaction between the alpha 2-adrenergic system and the nursing-induced changes in GH secretion could account for the discrepancy.
Localization (secretion) of GH
14) Confidence 0.80 Published 1993 Journal Acta Endocrinol. Section Abstract Doc Link 8383905 Disease Relevance 0 Pain Relevance 0.40
Finally, significant ultradian surges of GH secretion were observed in 35-day-old animals but only slight secretory episodes occurred in 24-day-old pups.
Localization (secretion) of GH
15) Confidence 0.80 Published 1981 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6970810 Disease Relevance 0 Pain Relevance 0.50
Finally, the inability of clonidine to stimulate GH secretion and the absence of significant ultradian surges before day 35 suggest that the noradrenergic mechanism and possibly other neural systems which trigger the surges of GH secretion observed in adult rats do not mature until after puberty.
Localization (secretion) of GH in neural associated with clonidine
16) Confidence 0.80 Published 1981 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6970810 Disease Relevance 0 Pain Relevance 0.47
These results suggest that the serotonergic and endogenous opiate systems involved in regulation of GH secretion in rats are functional within the first postnatal week.
Localization (secretion) of GH associated with opiate
17) Confidence 0.80 Published 1981 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6970810 Disease Relevance 0 Pain Relevance 0.50
Finally, the inability of clonidine to stimulate GH secretion and the absence of significant ultradian surges before day 35 suggest that the noradrenergic mechanism and possibly other neural systems which trigger the surges of GH secretion observed in adult rats do not mature until after puberty.
Localization (secretion) of GH in neural associated with clonidine
18) Confidence 0.80 Published 1981 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6970810 Disease Relevance 0 Pain Relevance 0.43
Apomorphine (0.5 mg/kg i.p.) had no effect on plasma GH levels, whereas clonidine (0.5 mg/kg i.p.) induced release of GH in both antiserum treated and control rats.
Localization (release) of GH in plasma associated with clonidine
19) Confidence 0.80 Published 1981 Journal Neuroendocrinology Section Abstract Doc Link 6114446 Disease Relevance 0 Pain Relevance 0.26
The results indicate that the alpha-adrenergic influence on the secretion of GH is mediated not by inhibition of somatostatin release but rather by effects on the release of a GHRF.
Localization (secretion) of GH associated with somatostatin
20) Confidence 0.80 Published 1981 Journal Neuroendocrinology Section Abstract Doc Link 6114446 Disease Relevance 0 Pain Relevance 0.25

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