INT87607

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2009
Negated 0
Speculated 2
Reported most in Abstract
Documents 25
Total Number 28
Disease Relevance 6.06
Pain Relevance 22.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcc) plasma membrane (Prkcc) nucleus (Prkcc)
kinase activity (Prkcc) response to stress (Prkcc) cytoplasm (Prkcc)
Anatomy Link Frequency
forebrain 6
spinal cord 3
dorsal horn 3
brain 2
interneurons 2
Prkcc (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 46 100.00 Very High Very High Very High
opioid receptor 37 100.00 Very High Very High Very High
Morphine 90 99.98 Very High Very High Very High
Spinal cord 33 99.92 Very High Very High Very High
nMDA receptor 5 99.66 Very High Very High Very High
Enkephalin 8 99.60 Very High Very High Very High
Dorsal horn 12 99.52 Very High Very High Very High
intrathecal 11 99.42 Very High Very High Very High
nociceptor 20 99.40 Very High Very High Very High
Hyperesthesia 3 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 18 99.96 Very High Very High Very High
Hypersensitivity 2 98.96 Very High Very High Very High
Pain 16 98.24 Very High Very High Very High
Neuropathic Pain 13 97.44 Very High Very High Very High
Hyperalgesia 14 97.04 Very High Very High Very High
Injury 6 96.36 Very High Very High Very High
Nociception 16 95.56 Very High Very High Very High
Hypertrophy 4 95.28 Very High Very High Very High
Nervous System Injury 4 89.20 High High
Vibrio Infection 3 74.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The protein level of PKCgamma was significantly up-regulated in membrane preparations of the limbic forebrain obtained from the morphine-conditioned mice compared to that from the saline-conditioned mice.
Positive_regulation (up-regulated) of PKCgamma in forebrain associated with morphine
1) Confidence 0.69 Published 2001 Journal Neuroscience Section Abstract Doc Link 11246146 Disease Relevance 0.05 Pain Relevance 0.80
These findings suggest that activated PKCgamma in the limbic forebrain following the treatment with morphine may be critical for the development and/or maintenance of reinforcing effects induced by morphine in mice.
Positive_regulation (activated) of PKCgamma in forebrain associated with morphine
2) Confidence 0.69 Published 2001 Journal Neuroscience Section Abstract Doc Link 11246146 Disease Relevance 0.10 Pain Relevance 0.98
These results suggest that the activation of spinal PKCgamma associated with the activation of ascending pain transmission may be an important factor in chronic pain-like hyperalgesia with changes in emotionality.
Positive_regulation (activation) of PKCgamma in spinal associated with pain, hyperalgesia and lasting pain
3) Confidence 0.69 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18242849 Disease Relevance 0.36 Pain Relevance 0.89
Events upstream of the NMDA receptor, especially the activation of the protein kinase Cgamma (PKCgamma), have been involved in the persistence of pain states associated with central sensitisation.
Positive_regulation (activation) of protein kinase Cgamma associated with pain and nmda receptor
4) Confidence 0.69 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14680764 Disease Relevance 0.68 Pain Relevance 0.80
Events upstream of the NMDA receptor, especially the activation of the protein kinase Cgamma (PKCgamma), have been involved in the persistence of pain states associated with central sensitisation.
Positive_regulation (activation) of PKCgamma associated with pain and nmda receptor
5) Confidence 0.69 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14680764 Disease Relevance 0.73 Pain Relevance 0.81
The present data provide direct evidence that the activation of mGlu5 receptor linked to the increased PKCgamma isoform in the mouse limbic forebrain is implicated in the development of rewarding effect of morphine.
Positive_regulation (increased) of PKCgamma in forebrain associated with morphine
6) Confidence 0.69 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15355330 Disease Relevance 0 Pain Relevance 0.68
Here we found for the first time that the treatment with MPEP significantly inhibited the up-regulation of PKCgamma isoform in the limbic forebrain of mice showing the significant place preference.
Positive_regulation (up-regulation) of PKCgamma in forebrain
7) Confidence 0.69 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15355330 Disease Relevance 0 Pain Relevance 0.71
Using immunoblot analysis, we confirmed that the increased level of protein kinase Cgamma (PKCgamma) isoform was observed in the limbic forebrain of ICR mice conditioned with morphine.
Positive_regulation (increased) of PKCgamma in forebrain associated with morphine
8) Confidence 0.69 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15355330 Disease Relevance 0 Pain Relevance 0.68
The prolonged exposure to 70% N2O caused an activation of PKCgamma isoform in the brain, but not the PKCepsilon isoform.
Positive_regulation (activation) of PKCgamma in brain
9) Confidence 0.64 Published 2007 Journal Neuroscience Section Abstract Doc Link 17681696 Disease Relevance 0 Pain Relevance 1.63
We demonstrated that mice tolerant to morphine exhibited a significant increase in the level of protein kinase Cgamma-like immunoreactivity (PKCgamma-IR) in the dorsal horn of the spinal cord.
Positive_regulation (increase) of PKCgamma in dorsal horn associated with dorsal horn, spinal cord and morphine
10) Confidence 0.60 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 14725643 Disease Relevance 0.14 Pain Relevance 0.88
These findings strongly support the idea that the sustained activation of neuronal PKCgamma is implicated in the increased levels of reactive astrocytes in the dorsal horn of the spinal cord following repeated treatment with morphine.
Positive_regulation (activation) of PKCgamma in neuronal associated with dorsal horn, morphine and spinal cord
11) Confidence 0.60 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 14725643 Disease Relevance 0.25 Pain Relevance 1.24
These findings indicate that repeated intrathecal administration of DAMGO may activate the PKCgamma isoform and in turn cause a desensitization of mu-receptor-mediated G-protein activation in the mouse spinal cord.
Spec (may) Positive_regulation (activate) of PKCgamma in spinal cord associated with spinal cord and intrathecal
12) Confidence 0.59 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356858 Disease Relevance 0 Pain Relevance 0.57
Here we report that mu-opioid receptor-mediated analgesia/antinociception and activation of G-proteins in the spinal cord are enhanced in PKCgamma knockout mice.
Positive_regulation (enhanced) of PKCgamma in spinal cord associated with targeted disruption, antinociception, opioid receptor, spinal cord and analgesia
13) Confidence 0.50 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11278552 Disease Relevance 0.35 Pain Relevance 0.96
The inhibition of morphine-induced increase in PKCgamma phosphorylation reduced Vps34 level.
Positive_regulation (increase) of PKCgamma associated with morphine
14) Confidence 0.49 Published 2009 Journal Synapse Section Abstract Doc Link 19173263 Disease Relevance 0 Pain Relevance 0.40
Conversely, chronic intrathecal delivery of exogenous galanin to nerve-intact adult rats is associated with persistent behavioural hypersensitivity, a significant increase in c-fos expression and an increase in PKCgamma immunoreactivity within the spinal cord dorsal horn.
Positive_regulation (increase) of PKCgamma in spinal cord dorsal horn associated with hypersensitivity, dorsal horn, spinal cord and intrathecal
15) Confidence 0.49 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10762308 Disease Relevance 0.90 Pain Relevance 0.49
PKCgamma is distributed strategically in the superficial layers of the dorsal horn and, thus, may serve as an important biochemical substrate in sensory signal processing including pain.
Positive_regulation (distributed) of PKCgamma in dorsal horn associated with pain and dorsal horn
16) Confidence 0.47 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11278552 Disease Relevance 0.23 Pain Relevance 0.72
This study identifies the PKCgamma as a key element that links opioid receptor activation with the recruitment of opposite systems to opioid analgesia involved in a physiological compensatory pain enhancement.
Positive_regulation (activation) of PKCgamma associated with pain, opioid receptor, opioid and analgesia
17) Confidence 0.46 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14680764 Disease Relevance 1.03 Pain Relevance 1.22
Using immunoblot analysis, we confirmed that the increased level of protein kinase Cgamma (PKCgamma) isoform was observed in the limbic forebrain of ICR mice conditioned with morphine.
Positive_regulation (increased) of protein kinase Cgamma in forebrain associated with morphine
18) Confidence 0.46 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15355330 Disease Relevance 0 Pain Relevance 0.68
The treatment with morphine increases PKCgamma and Vps34 levels.
Positive_regulation (increases) of PKCgamma associated with morphine
19) Confidence 0.46 Published 2009 Journal Synapse Section Abstract Doc Link 19173263 Disease Relevance 0 Pain Relevance 0.40
Thus, activation of brain PKC, in particular, the PKCgamma isoform, appears to play an important role in the development of both acute tolerance and cross-tolerance to N2O-induced antinociception in mice.
Spec (appears) Positive_regulation (activation) of PKCgamma in brain associated with antinociception, kinase c and tolerance
20) Confidence 0.43 Published 2007 Journal Neuroscience Section Abstract Doc Link 17681696 Disease Relevance 0 Pain Relevance 1.57

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