INT8761

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 1986
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 3.59
Pain Relevance 8.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) aging (Calca) extracellular region (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
spinal cord 6
dorsal root ganglion 6
gonadotroph 2
vessels 2
spleen 2
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 95 100.00 Very High Very High Very High
dorsal root ganglion 76 100.00 Very High Very High Very High
antagonist 65 100.00 Very High Very High Very High
calcitonin gene related peptide 13 100.00 Very High Very High Very High
bDMF 1 100.00 Very High Very High Very High
Morphine 3 99.60 Very High Very High Very High
Nicotine 11 99.08 Very High Very High Very High
Spinal cord 18 98.52 Very High Very High Very High
withdrawal 11 97.76 Very High Very High Very High
substance P 26 97.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 80 100.00 Very High Very High Very High
Inflammatory Pain 42 95.44 Very High Very High Very High
INFLAMMATION 71 94.16 High High
Neuropathic Pain 87 94.00 High High
Nervous System Injury 31 93.16 High High
Hyperalgesia 81 87.28 High High
Arthritis 4 87.24 High High
Disseminated Intravascular Coagulation 1 80.92 Quite High
Cv Unclassified Under Development 2 71.28 Quite High
Hypoxia 3 70.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Release was assessed using microprobes coated with antibody to calcitonin gene-related peptide; inhibition of binding of [125I]calcitonin gene-related peptide to these probes following insertion into the spinal cord is equated with intraspinal release of the endogenous (unlabelled) peptide.
Negative_regulation (inhibition) of calcitonin Binding (binding) of in spinal cord associated with spinal cord and calcitonin gene-related peptide
1) Confidence 0.43 Published 1994 Journal Neuroscience Section Abstract Doc Link 7845599 Disease Relevance 0.25 Pain Relevance 0.50
Release was assessed using microprobes coated with antibody to calcitonin gene-related peptide; inhibition of binding of [125I]calcitonin gene-related peptide to these probes following insertion into the spinal cord is equated with intraspinal release of the endogenous (unlabelled) peptide.
Negative_regulation (inhibition) of calcitonin Binding (binding) of in spinal cord associated with spinal cord and calcitonin gene-related peptide
2) Confidence 0.43 Published 1994 Journal Neuroscience Section Abstract Doc Link 7845599 Disease Relevance 0.25 Pain Relevance 0.51
It was found that the ability of acetylcholine to cause relaxation was reduced by CGRP receptor blocking with CGRP8-37 in vessels from control rats, but returned to pre-blocking levels after washout of the antagonist.
Negative_regulation (blocking) of CGRP Binding (receptor) of in vessels associated with antagonist
3) Confidence 0.42 Published 1994 Journal Artery Section Abstract Doc Link 7980030 Disease Relevance 0 Pain Relevance 0.14
Immunoreactivity for CGRP was decreased 31.5% at 8 h and variable at other time points.
Negative_regulation (decreased) of CGRP Binding (Immunoreactivity) of associated with calcitonin gene-related peptide
4) Confidence 0.38 Published 1992 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 1379098 Disease Relevance 0.38 Pain Relevance 1.10
Half-maximal inhibition of rat [125I]iodo-CGRP binding to membranes of the rat atria and the spleen was obtained with, respectively, 5 and 0.35 nM unlabeled rat CGRP; these values correspond to EC50 values of 3 and 0.14 nM for activation of adenylate cyclase by CGRP.
Negative_regulation (inhibition) of iodo-CGRP Binding (binding) of in spleen associated with calcitonin gene-related peptide
5) Confidence 0.38 Published 1986 Journal Endocrinology Section Abstract Doc Link 3013594 Disease Relevance 0 Pain Relevance 0.45
We confirmed that rats chronically treated with morphine showed significant decreases in [125I]CGRP alpha binding in laminae I, II, and III of the L4 spinal cord, while CGRP-like immunostaining was increased in these same laminae.
Negative_regulation (decreases) of CGRP Binding (binding) of in spinal cord associated with calcitonin gene related peptide, spinal cord and morphine
6) Confidence 0.38 Published 1995 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8846407 Disease Relevance 0.16 Pain Relevance 1.80
Pretreatment with CGRP 8-37 (CGRP receptor antagonist) and NK-1 but not NK-2 nor NK-3 receptor antagonists significantly reduced the HABF by 43% (p< 0.05) and 25% (p< 0.05) as compared to the HABF value in the control HABR group.
Neg (not) Negative_regulation (reduced) of CGRP Binding (Pretreatment) of associated with antagonist
7) Confidence 0.30 Published 2005 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 15795481 Disease Relevance 0.14 Pain Relevance 0.42
AUC: area under the curve; CFA: complete Freund's adjuvant; CGRP: calcitonin gene-related peptide; DRG: dorsal root ganglion; HPL: hot plate latency; IB4: isolectin B4; NF200: neurofilament 200; PWT: paw withdrawal threshold; TRPV1: transient receptor potential vanilloid 1.


Negative_regulation (latency) of calcitonin gene-related peptide Binding (ganglion) of in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, withdrawal and calcitonin gene-related peptide
8) Confidence 0.27 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628345 Disease Relevance 1.06 Pain Relevance 1.07
AUC: area under the curve; CFA: complete Freund's adjuvant; CGRP: calcitonin gene-related peptide; DRG: dorsal root ganglion; HPL: hot plate latency; IB4: isolectin B4; NF200: neurofilament 200; PWT: paw withdrawal threshold; TRPV1: transient receptor potential vanilloid 1.


Negative_regulation (latency) of CGRP Binding (ganglion) of in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, withdrawal and calcitonin gene-related peptide
9) Confidence 0.27 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628345 Disease Relevance 1.07 Pain Relevance 1.07
In the strips treated with L-NA, the nicotine-induced relaxation was abolished or markedly reduced under desensitization with vasoactive intestinal peptide (VIP) or calcitonin gene-related peptide (CGRP) and by treatment with high concentrations of beraprost, a stable analog of prostaglandin I2, but was unaffected by CGRP or VIP receptor antagonists.
Negative_regulation (reduced) of CGRP Binding (desensitization) of associated with antagonist, nicotine and calcitonin gene-related peptide
10) Confidence 0.23 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9726629 Disease Relevance 0 Pain Relevance 0.43
In the strips treated with L-NA, the nicotine-induced relaxation was abolished or markedly reduced under desensitization with vasoactive intestinal peptide (VIP) or calcitonin gene-related peptide (CGRP) and by treatment with high concentrations of beraprost, a stable analog of prostaglandin I2, but was unaffected by CGRP or VIP receptor antagonists.
Negative_regulation (reduced) of gene-related peptide Binding (desensitization) of associated with antagonist, nicotine and calcitonin gene-related peptide
11) Confidence 0.20 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9726629 Disease Relevance 0 Pain Relevance 0.42
Well explored paracrine systems are: (i) the gonadotroph–lactotroph axis, of which the mediators remain incompletely defined but could be in part angiotensin II, PACAP, N-POMC and calcitonin; (ii) the gonadotroph–somatotroph axis, which is particularly well developed in fish; (ii) a cholinergic system in corticotrophs targeting somatotrophs, lactotrophs and FS cells; (iii) a GABA-ergic system in somatotrophs; (iv) several inhibitory systems targeting gonadotrophs (e.g. galanin and PRL from lactotrophs and ?
Negative_regulation (be) of calcitonin Binding (part) of in gonadotroph associated with gaba
12) Confidence 0.16 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.13
BDNF: brain derived neurotrophic factor; CGRP: calcitonin gene related peptide; DLF: dorsal lateral funiculus; DRG: dorsal root ganglia; NGF: nerve growth factor; sEPSC spontaneous excitatory postsynaptic potential; SNI: spared nerve injury.


Negative_regulation (derived) of CGRP Binding (factor) of in dorsal root ganglia associated with calcitonin gene related peptide, nervous system injury, nerve growth factor and bdmf
13) Confidence 0.14 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 0.27 Pain Relevance 0.28

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox