INT87623

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 5.32
Pain Relevance 7.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cofactor metabolic process (PPT1) Golgi apparatus (PPT1) cytosol (PPT1)
extracellular space (PPT1) protein modification process (PPT1) extracellular region (PPT1)
Anatomy Link Frequency
pancreas 1
finger 1
lymphoblasts 1
PPT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 15 100.00 Very High Very High Very High
Pain threshold 10 100.00 Very High Very High Very High
tolerance 4 100.00 Very High Very High Very High
adenocard 2 100.00 Very High Very High Very High
tramadol 300 99.12 Very High Very High Very High
antagonist 54 98.76 Very High Very High Very High
Neuropeptide 3 98.16 Very High Very High Very High
Pain 41 98.04 Very High Very High Very High
Chronic pancreatitis 18 96.72 Very High Very High Very High
potassium channel 1 94.44 High High
Disease Link Frequency Relevance Heat
Pain 48 100.00 Very High Very High Very High
Apoptosis 5 99.92 Very High Very High Very High
Pancreatitis 21 96.72 Very High Very High Very High
Death 2 95.04 Very High Very High Very High
Low Back Pain 1 94.04 High High
Hypoalagesia 4 92.56 High High
Dyskinesias 10 89.44 High High
Referred Pain 3 88.64 High High
Neurodegenerative Disease 2 75.20 Quite High
Reprotox - General 3 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, in situ hybridization histochemistry was used to investigate the effect of chronic L-DOPA administration on the activity of the direct and indirect striatal output pathways by measuring striatal preprotachykinin (PPT), preproenkephalin-A (PPE-A) and adenosine-2a (A2a) receptor gene expression in these monkeys.
Gene_expression (expression) of PPT associated with adenocard
1) Confidence 0.75 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10762340 Disease Relevance 0.59 Pain Relevance 0.09
METHODS: Tissue samples from patients with CP (n = 25) and from healthy donors (n = 20) were analyzed for PPT-A, NK-2R, NK-3R, and NEP expression using quantitative RT-PCR.
Gene_expression (expression) of PPT
2) Confidence 0.75 Published 2007 Journal Ann. Surg. Section Body Doc Link 17968170 Disease Relevance 0.19 Pain Relevance 0
RESULTS: In CP tissues, NK-2R and PPT-A expression was increased, whereas NK-3R and NEP mRNA levels were comparable with normal pancreas.
Gene_expression (expression) of PPT in pancreas
3) Confidence 0.75 Published 2007 Journal Ann. Surg. Section Body Doc Link 17968170 Disease Relevance 0.15 Pain Relevance 0
So far, expression of SP receptors NK-2R, NK-3R, the SP-encoding gene preprotachykinin A (PPT-A), and the SP degradation enzyme neutral endopeptidase (NEP) and their relation to pain in CP have not been determined.
Spec (determined) Gene_expression (expression) of PPT associated with pain, chronic pancreatitis and substance p
4) Confidence 0.65 Published 2007 Journal Ann. Surg. Section Abstract Doc Link 17968170 Disease Relevance 0.62 Pain Relevance 0.92
OBJECTIVE: To determine the effect of physical and mental stressors on pressure pain threshold (PPT), and pressure pain tolerance (PTOL) values, and to compare these different types of stressors on its ability to affect PPT and PTOL values in young women.
Gene_expression (values) of PPT associated with pain, pain threshold and tolerance
5) Confidence 0.65 Published 2009 Journal Saudi Med J Section Abstract Doc Link 19370271 Disease Relevance 0.54 Pain Relevance 0.76
During the cold-induced pain, a significant PPT elevation was found at all test sites in men (P < .023) and at all sites (P < .021) except for the finger in women.
Gene_expression (elevation) of PPT in finger
6) Confidence 0.65 Published 2010 Journal J Orofac Pain Section Body Doc Link 20664826 Disease Relevance 0 Pain Relevance 0
The HPT and PPT were higher in trimester 3 as compared to trimesters 1 and 2 (P < .012).
Gene_expression (higher) of PPT associated with pain threshold
7) Confidence 0.58 Published 2002 Journal J Pain Section Abstract Doc Link 14622731 Disease Relevance 2.48 Pain Relevance 2.56
Regular peristalsis reoccurred in these two segments, however, with a slightly higher PPT than in the initial control period.
Gene_expression (reoccurred) of PPT
8) Confidence 0.34 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC1839083 Disease Relevance 0 Pain Relevance 1.08
A more pronounced increase of PPT was caused by 30 ?
Gene_expression (pronounced) of PPT
9) Confidence 0.34 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC1839083 Disease Relevance 0 Pain Relevance 0.99
Pre-treatment with a combination of the 5-HT receptor antagonists methysergide plus tropisetron did not affect the increase of PPT caused by the equieffective concentrations of 30 ?
Gene_expression (caused) of PPT associated with antagonist
10) Confidence 0.34 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC1839083 Disease Relevance 0 Pain Relevance 1.12
We show that flupirtine aborts etoposide-induced apoptosis in CLN1-, CLN2-, CLN3-, and CLN6-deficient as well as normal lymphoblasts.
Gene_expression (deficient) of CLN1 in lymphoblasts associated with apoptosis
11) Confidence 0.30 Published 2002 Journal Ann. Neurol. Section Abstract Doc Link 11921051 Disease Relevance 0.61 Pain Relevance 0.14
RESULTS: It was found that NGF significantly reduced PPT and PPTOL 3 hours, 1 and 7 days postinjection (P < .001).
Gene_expression (hours) of PPT
12) Confidence 0.05 Published 2008 Journal J Orofac Pain Section Body Doc Link 19090407 Disease Relevance 0.14 Pain Relevance 0

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