INT87624

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Context Info
Confidence 0.49
First Reported 2000
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.75
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cofactor metabolic process (PPT1) Golgi apparatus (PPT1) cytosol (PPT1)
extracellular space (PPT1) protein modification process (PPT1) extracellular region (PPT1)
Anatomy Link Frequency
pancreas 2
PPT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 2 100.00 Very High Very High Very High
tramadol 100 99.08 Very High Very High Very High
opioid receptor 14 65.24 Quite High
Chronic pancreatitis 6 50.00 Quite Low
Pain 6 50.00 Quite Low
Potency 5 47.96 Quite Low
Enkephalin 1 25.00 Low Low
Analgesic 13 16.12 Low Low
Serotonin 2 12.36 Low Low
monoamine 1 9.80 Low Low
Disease Link Frequency Relevance Heat
Dyskinesias 10 90.92 High High
Pancreatitis 7 77.44 Quite High
Pain 7 77.20 Quite High
Parkinson's Disease 1 76.24 Quite High
Disease 1 73.80 Quite High
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Diabetic Neuropathy 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low
Neuropathic Pain 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, in situ hybridization histochemistry was used to investigate the effect of chronic L-DOPA administration on the activity of the direct and indirect striatal output pathways by measuring striatal preprotachykinin (PPT), preproenkephalin-A (PPE-A) and adenosine-2a (A2a) receptor gene expression in these monkeys.
Spec (investigate) Positive_regulation (measuring) of Gene_expression (expression) of PPT associated with adenocard
1) Confidence 0.49 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10762340 Disease Relevance 0.59 Pain Relevance 0.09
RESULTS: In CP tissues, NK-2R and PPT-A expression was increased, whereas NK-3R and NEP mRNA levels were comparable with normal pancreas.
Positive_regulation (increased) of Gene_expression (expression) of PPT in pancreas
2) Confidence 0.49 Published 2007 Journal Ann. Surg. Section Body Doc Link 17968170 Disease Relevance 0.15 Pain Relevance 0
A more pronounced increase of PPT was caused by 30 ?
Positive_regulation (increase) of Gene_expression (pronounced) of PPT
3) Confidence 0.26 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC1839083 Disease Relevance 0 Pain Relevance 0.99

General Comments

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