INT87632

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Context Info
Confidence 0.45
First Reported 1999
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 32
Total Number 32
Disease Relevance 29.47
Pain Relevance 4.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PECAM1) extracellular space (PECAM1) cell adhesion (PECAM1)
plasma membrane (PECAM1)
Anatomy Link Frequency
endothelial cell 9
leukocytes 8
granulocytes 4
monocytes 3
brain 2
PECAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 205 100.00 Very High Very High Very High
Inflammatory mediators 15 99.20 Very High Very High Very High
Inflammatory response 64 98.96 Very High Very High Very High
Paracetamol 11 98.36 Very High Very High Very High
chemokine 118 98.26 Very High Very High Very High
Pain 24 97.92 Very High Very High Very High
cINOD 4 94.80 High High
Inflammation 473 94.56 High High
endometriosis 70 92.64 High High
antagonist 41 86.64 High High
Disease Link Frequency Relevance Heat
Adhesions 607 100.00 Very High Very High Very High
Cancer 106 100.00 Very High Very High Very High
Infection 39 99.98 Very High Very High Very High
Hyperplasia 3 99.92 Very High Very High Very High
Disease 284 99.82 Very High Very High Very High
Nicotine Addiction 763 99.32 Very High Very High Very High
INFLAMMATION 544 99.20 Very High Very High Very High
Pulmonary Disease 216 99.16 Very High Very High Very High
Drug Induced Neurotoxicity 2 99.16 Very High Very High Very High
Injury 88 98.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, although smokers had thus retained the ability to upregulate adhesion molecule expression, an integral part of the inflammatory response, other signs of smoking-induced immune dysregulation in the gingival microvasculature were apparent.
Positive_regulation (upregulate) of Gene_expression (expression) of adhesion molecule associated with inflammatory response, nicotine addiction and adhesions
1) Confidence 0.45 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.78 Pain Relevance 0.17
However, although smokers had thus retained the ability to upregulate adhesion molecule expression, an integral part of the inflammatory response, other signs of smoking-induced immune dysregulation in the gingival microvasculature were apparent.
Positive_regulation (upregulate) of Gene_expression (expression) of adhesion molecule associated with inflammatory response, nicotine addiction and adhesions
2) Confidence 0.45 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.78 Pain Relevance 0.17
RESULTS: In a drug free group, digestion of a single tablet of aspirin resulted in a significantly (p<0.05) diminished expression of PECAM-1, GP IIb, fibrinogen binding with PAC-1 antibody, GP Ib, P-selectin, and CD151.
Positive_regulation (resulted) of Gene_expression (expression) of PECAM-1
3) Confidence 0.41 Published 2001 Journal Thromb. Res. Section Body Doc Link 11728532 Disease Relevance 0.07 Pain Relevance 0
This was associated with increased expression of platelet endothelial cell adhesion molecule-1 (PECAM-1) but not of intercellular adhesion molecule-1 (ICAM-1), P-selectin or E-selectin (Okouchi et al 2002).


Neg (not) Positive_regulation (increased) of Gene_expression (expression) of PECAM-1 in endothelial cell associated with adhesions
4) Confidence 0.36 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 1.78 Pain Relevance 0.05
B activation in the upregulation of endothelial adhesion molecule expression.
Positive_regulation (upregulation) of Gene_expression (expression) of adhesion molecule associated with adhesions
5) Confidence 0.33 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.19 Pain Relevance 0.14
B activation in the upregulation of endothelial adhesion molecule expression.
Positive_regulation (upregulation) of Gene_expression (expression) of adhesion molecule associated with adhesions
6) Confidence 0.33 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.19 Pain Relevance 0.14
A similar procedure was followed in analyzing cells for CD31-FITC expression except that intrinsic FITC fluorescence was determined in unlabeled arachnoidal cells by exciting cells with a 488 mn argon laser and detecting their fluorescent emission in the FL1 channel which detects fluorescent wavelengths from 515–545 nm.


Positive_regulation (followed) of Gene_expression (expression) of CD31-FITC
7) Confidence 0.27 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 0.26 Pain Relevance 0
Of the 3,767 events that fell within R2 and were subsequently analyzed for CD31-FITC expression, 3,761 (99.8%) also fell within the gate M2 and were considered negative for CD31 expression.
Positive_regulation (negative) of Gene_expression (expression) of CD31
8) Confidence 0.27 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1285366 Disease Relevance 0 Pain Relevance 0
Furthermore, it has been recently demonstrated that monocytes can acquire endothelial markers in vitro by uptake of platelet microparticles, as a simple transfer of antigens CD31 and vWF [28].
Positive_regulation (transfer) of Gene_expression (transfer) of CD31 in platelet
9) Confidence 0.27 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2881111 Disease Relevance 0.17 Pain Relevance 0.06
This was associated with increased expression of platelet endothelial cell adhesion molecule-1 (PECAM-1) but not of intercellular adhesion molecule-1 (ICAM-1), P-selectin or E-selectin (Okouchi et al 2002).


Neg (not) Positive_regulation (increased) of Gene_expression (expression) of platelet endothelial cell adhesion molecule-1 in endothelial cell associated with adhesions
10) Confidence 0.26 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 1.78 Pain Relevance 0.05
Of note, our IHC findings demonstrated an increased PGP9.5 and CD31 expression in the IAF and OAF of the surgical degenerate samples in comparison to the healthy, indicating that more neuronal and endothelial cell types were present in these samples.
Positive_regulation (increased) of Gene_expression (expression) of CD31 in endothelial cell
11) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0 Pain Relevance 0.10
Of note, our IHC findings demonstrated an increased PGP9.5 and CD31 expression in the IAF and OAF of the surgical degenerate samples in comparison to the healthy, indicating that more neuronal and endothelial cell types were present in these samples.
Positive_regulation (increased) of in neuronal Gene_expression (expression) of CD31 in endothelial cell
12) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0 Pain Relevance 0.10
One cellular adhesion protein called epithelial cell adhesion molecule (EpCAM) is a 40 kDa cell surface glycoprotein that mediates epithelium-specific, homotypic cell to cell adhesion on normal cells.55,56 EpCAM is a significant tumor antigen because its overexpression has been observed in a majority of carcinomas including ovarian cancer, breast cancer, prostate cancer, and nonsmall cell lung cancer.56 The inhibition of this antigen has been associated with a decrease in the proliferation, migration, and invasion of cancer cells, therefore making it an important target for cancer immunotherapy.


Positive_regulation (overexpression) of Gene_expression (overexpression) of adhesion molecule in lung associated with non-small-cell lung cancer, cancer, ovarian cancer, carcinoma, immunotherapy of cancer, reprotox - general 1 and adhesions
13) Confidence 0.07 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880345 Disease Relevance 2.91 Pain Relevance 0.06
Results from the present study demonstrate an increased expression of the adhesion molecule CD11b by both neutrophils and monocytes following tourniquet-applied upper limb orthopaedic surgery.
Positive_regulation (increased) of Gene_expression (expression) of adhesion molecule in upper limb associated with adhesions
14) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.81 Pain Relevance 0.08
It is hypothesized that, in part, this occurs secondary to endothelial damage and increased adhesion molecule expression resulting from increased oxidant burden.
Positive_regulation (increased) of Gene_expression (expression) of adhesion molecule associated with adhesions
15) Confidence 0.04 Published 2001 Journal Respir Res Section Body Doc Link PMC59517 Disease Relevance 1.16 Pain Relevance 0
is a central mediator of neuroinflammation after brain injury [19], inducing generalized endothelial activation/injury [27], direct neurotoxicity [28], reduced BBB integrity [23,29], and upregulated adhesion molecule expression [24,25,30], thus promoting leukocyte-EC interactions and cellular infiltration of injured brain parenchyma [31,32].
Positive_regulation (upregulated) of Gene_expression (expression) of adhesion molecule in brain associated with drug induced neurotoxicity, injury, adhesions and brain injury
16) Confidence 0.04 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 1.16 Pain Relevance 0.23
If the white blood cells, especially the granulocytes, are activated

they will increase the expression of adhesion molecules on their surface.

Positive_regulation (increase) of Gene_expression (expression) of adhesion in granulocytes associated with adhesions
17) Confidence 0.03 Published 1999 Journal Crit Care Section Body Doc Link PMC29032 Disease Relevance 0.73 Pain Relevance 0.21
Several studies have demonstrated an increased expression of CD18 and

CD11b adhesion molecules on granulocytes after 15-30 min of haemodialysis, whereas the expression of CD62L on granulocytes was decreased.

Positive_regulation (increased) of Gene_expression (expression) of adhesion in granulocytes associated with adhesions
18) Confidence 0.02 Published 1999 Journal Crit Care Section Body Doc Link PMC29032 Disease Relevance 1.31 Pain Relevance 0.05
Expression of platelet endothelial cell adhesion molecule, a measure of small vessel density, and endothelial nitric oxide synthase (NOS), a downstream target of VEGFR2, were increased at 48 and 72 h following toxic doses of APAP, and treatment with SU5416 decreased their expression.
Positive_regulation (increased) of Gene_expression (Expression) of adhesion molecule in endothelial cell associated with paracetamol and adhesions
19) Confidence 0.02 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16565415 Disease Relevance 0.68 Pain Relevance 0.56
can induce intercellular adhesion molecule (ICAM)-1 expression.
Positive_regulation (induce) of Gene_expression (expression) of adhesion molecule associated with adhesions
20) Confidence 0.02 Published 2004 Journal Clin Mol Allergy Section Body Doc Link PMC425596 Disease Relevance 0.84 Pain Relevance 0.20

General Comments

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