INT87637

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Context Info
Confidence 0.63
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 4.42
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ang) extracellular space (Ang) extracellular region (Ang)
RNA binding (Ang) nucleus (Ang) nuclease activity (Ang)
Anatomy Link Frequency
colon 2
myocytes 1
plasma 1
cardiac myocytes 1
fibroblasts 1
Ang (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 22 100.00 Very High Very High Very High
tetrodotoxin 3 99.84 Very High Very High Very High
antagonist 27 95.44 Very High Very High Very High
metalloproteinase 23 92.48 High High
fibrosis 8 86.08 High High
Inflammation 49 75.88 Quite High
Calcium channel 2 62.92 Quite High
member 8 1 61.68 Quite High
Potency 4 54.88 Quite High
Angina 1 50.00 Quite Low
Disease Link Frequency Relevance Heat
Disease 32 100.00 Very High Very High Very High
Alzheimer's Dementia 3 99.20 Very High Very High Very High
Apoptosis 24 98.60 Very High Very High Very High
Premature Birth 40 98.40 Very High Very High Very High
Amnesia 2 97.32 Very High Very High Very High
Lymphatic System Cancer 62 96.88 Very High Very High Very High
Cv Unclassified Under Development 30 96.00 Very High Very High Very High
Rupture 6 95.92 Very High Very High Very High
Diabetes Mellitus 30 95.32 Very High Very High Very High
Hypertension 15 89.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
7 mol/L Ang-(1–7) for one hour led to an intense nuclear fluorescence with both antibodies, proofing nuclear translocation of NF-?
Localization (fluorescence) of Ang
1) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672164 Disease Relevance 0.21 Pain Relevance 0.09
Likewise, ARBs increase plasma renin activity due to inhibition of the Ang II-renin release feedback loop [46].
Localization (release) of Ang in plasma
2) Confidence 0.53 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.75 Pain Relevance 0
Moreover, the translocation of NF-kappaB in nucleus resulted from Ang II was reduced by treatment with U0126.
Localization (translocation) of Ang in nucleus
3) Confidence 0.52 Published 2009 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 19546355 Disease Relevance 0.67 Pain Relevance 0.09
After obtaining basal recordings for 10 min, myocytes were exposed to Ang II (10 nM) or isoproterenol (ISO, 100 nM; both Sigma, Taufkirchen, Germany) in the presence or absence of ANP (mouse ANP, 100 nM; Bachem, Heidelberg, Germany) (superfusion of cardiomyocytes with ANP or vehicle during 10 min; then superfusion with Ang II or ISO in the presence of ANP during additional 10 min).


Localization (presence) of Ang in myocytes
4) Confidence 0.50 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0 Pain Relevance 0
It inhibits renin release and Ang II-stimulated aldosterone production [29, 31] and antagonizes the vasoconstrictor, sympathotonic, and antinatriuretic actions of Ang II [22], but also inhibits trophic effects of Ang II on cultured cardiac myocytes and fibroblasts [9].
Localization (release) of Ang in fibroblasts
5) Confidence 0.47 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0.38 Pain Relevance 0.04
Of interest, the ability of MSC cultures of secreting high levels of angiogenic cytokines, such as VEGF, IL-8, angiogenin and CCL2, was significantly (p<0.01) enhanced by the concomitant presence of lymphoma cells.
Localization (secreting) of angiogenin associated with lymphatic system cancer and cytokine
6) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886845 Disease Relevance 0.87 Pain Relevance 0.09
 ; AD: Alzheimer's disease; Ang: angiotensin; FDA: Food and Drug Administration; IRAP: insulin-regulated aminopeptidase; LVV-H7: LVV-hemorphin 7.


Localization (disease) of Ang associated with disease
7) Confidence 0.17 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0.49 Pain Relevance 0
It inhibits renin release and Ang II-stimulated aldosterone production [29, 31] and antagonizes the vasoconstrictor, sympathotonic, and antinatriuretic actions of Ang II [22], but also inhibits trophic effects of Ang II on cultured cardiac myocytes and fibroblasts [9].
Localization (release) of Ang in cardiac myocytes
8) Confidence 0.16 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0.38 Pain Relevance 0.04
An increase in midtrimester concentrations of amniotic fluid MMP-8, IL-6, and angiogenin are risk factors for early spontaneous preterm delivery (<32 weeks).
Localization (concentrations) of angiogenin in amniotic fluid associated with premature birth
9) Confidence 0.15 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.58 Pain Relevance 0.16
The effect of ANG II on mucosal ion transport and localization of ANG type 1 receptor (AT(1)R) in the guinea pig distal colon was investigated.
Localization (localization) of ANG in colon
10) Confidence 0.13 Published 2000 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 10762617 Disease Relevance 0 Pain Relevance 0.09
The ANG II (10(-6) M)-evoked response was mainly due to Cl(-) secretion.
Localization (secretion) of ANG
11) Confidence 0.11 Published 2000 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 10762617 Disease Relevance 0 Pain Relevance 0.22
These results suggest that ANG II-evoked electrogenic Cl(-) secretion may involve submucosal cholinergic and tachykinergic neurons and prostanoid synthesis pathways through AT(1)R on the submucosal plexus and surface epithelial cells in guinea pig distal colon.
Localization (secretion) of ANG in colon
12) Confidence 0.11 Published 2000 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 10762617 Disease Relevance 0 Pain Relevance 0.20
AIM: To evaluate the reasons for troponin I (cTnI) release after ExT, and to determine its clinical and prognostic implications in patients with stable CAD, referred for elective coronary angiography (ANG).
Localization (referred) of ANG
13) Confidence 0.05 Published 2010 Journal Kardiol Pol Section Body Doc Link 20425701 Disease Relevance 0.09 Pain Relevance 0

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