INT8764

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Context Info
Confidence 0.45
First Reported 1991
Last Reported 2009
Negated 1
Speculated 2
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.62
Pain Relevance 3.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cyp3a23/3a1) endoplasmic reticulum (Cyp3a23/3a1)
Anatomy Link Frequency
liver 4
male-specific 2
body 2
Cyp3a23/3a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 19 100.00 Very High Very High Very High
Buprenorphine 14 99.80 Very High Very High Very High
dexamethasone 8 99.76 Very High Very High Very High
carbamazepine 12 99.20 Very High Very High Very High
tolerance 1 97.80 Very High Very High Very High
alcohol 3 83.96 Quite High
addiction 1 80.32 Quite High
cINOD 2 77.04 Quite High
Inflammation 1 76.56 Quite High
depression 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Liver Cancer 1 99.58 Very High Very High Very High
Toxicity 5 96.72 Very High Very High Very High
Hypoxia 1 90.76 High High
Convulsion 4 86.88 High High
Partial Seizures 1 84.08 Quite High
Opiate Addiction 1 80.32 Quite High
Appetite Loss 1 76.76 Quite High
Poisoning 1 76.56 Quite High
INFLAMMATION 1 76.56 Quite High
Epilepsy 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results suggest that administration of APAP at a subtoxic dose may result in an induction of hepatic CYP enzymes, thereby altering metabolism and toxicological consequences of various chemical substances that are substrates for the same enzyme system.
Spec (may) Positive_regulation (result) of Positive_regulation (induction) of CYP associated with paracetamol
1) Confidence 0.45 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19834287 Disease Relevance 0.14 Pain Relevance 1.06
We investigated the effects on ventilation of 30 mg kg(-1) buprenorphine alone or following cytochrome P450 (CYP) 3A induction with dexamethasone, using whole body plethysmography (N=24) and arterial blood gases (N=12).
Positive_regulation (following) of Positive_regulation (induction) of CYP in body associated with dexamethasone and buprenorphine
2) Confidence 0.35 Published 2006 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17084876 Disease Relevance 0.23 Pain Relevance 1.22
Previous in vitro studies suggested that caffeine enhanced acetaminophen (APAP) oxidation to N-acetyl-p-benzoquinone imine (NAPQI) by selectively activating the male-specific constitutive cytochrome P-450IIIA2.
Positive_regulation (enhanced) of Positive_regulation (activating) of P-450IIIA2 in male-specific associated with paracetamol
3) Confidence 0.09 Published 1991 Journal Drug Metab. Dispos. Section Abstract Doc Link 1686244 Disease Relevance 0 Pain Relevance 0.34
In the HepG2 human liver cancer cell line, sulindac caused a sustained, dose-dependent increase in CYP enzyme activity.
Positive_regulation (caused) of Positive_regulation (increase) of CYP in liver associated with liver cancer
4) Confidence 0.07 Published 2006 Journal Carcinogenesis Section Abstract Doc Link 16531450 Disease Relevance 0.18 Pain Relevance 0.12
With the possible exception of the P450IIIA isozyme of the cytochrome P450 family, neither oxcarbazepine nor its monohydroxy derivative induce hepatic oxidative metabolism.
Neg (nor) Positive_regulation (induce) of Neg (exception) Spec (possible) Positive_regulation (exception) of P450IIIA isozyme
5) Confidence 0.02 Published 1992 Journal Drugs Section Abstract Doc Link 1379159 Disease Relevance 0.61 Pain Relevance 0.36
In addition to ADH, ethanol can be oxidized by liver microsomes: studies over the last twenty years have culminated in the molecular elucidation of the ethanol-inducible cytochrome P450 (P450IIE1) which contributes not only to ethanol metabolism and tolerance, but also to the toxicity of various xenobiotics.
Positive_regulation (culminated) of Positive_regulation (ethanol-inducible) of P450IIE1 in liver associated with toxicity and tolerance
6) Confidence 0.00 Published 1991 Journal Alcohol Alcohol Suppl Section Abstract Doc Link 1845551 Disease Relevance 0.47 Pain Relevance 0.24

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