INT87644

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Context Info
Confidence 0.80
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 2.08
Pain Relevance 7.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (SGSM3) cell cycle (SGSM3) cytoplasm (SGSM3)
Anatomy Link Frequency
astrocytes 1
neutrophils 1
SGSM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 13 99.70 Very High Very High Very High
Immobilon 6 99.46 Very High Very High Very High
Enkephalin 13 99.44 Very High Very High Very High
agonist 21 99.00 Very High Very High Very High
Cannabinoid 16 99.00 Very High Very High Very High
opioid receptor 21 98.84 Very High Very High Very High
Opioid 20 98.60 Very High Very High Very High
MU agonist 2 98.56 Very High Very High Very High
antagonist 5 98.32 Very High Very High Very High
Nerve growth factor 4 98.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 134 96.56 Very High Very High Very High
Hereditary Sensory And Autonomic Neuropathies 6 96.44 Very High Very High Very High
Apoptosis 5 92.84 High High
Hypoxia 1 92.72 High High
Infection 3 90.28 High High
Lacerations 1 85.00 Quite High
Bordatella Infection 1 82.24 Quite High
Stress 7 77.84 Quite High
Inflammatory Bowel Disease 94 75.28 Quite High
Arthritis 2 71.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, mutant receptors that fail to undergo agonist-mediated internalization are able to efficiently phosphorylate MAP kinases.
Phosphorylation (phosphorylate) of MAP associated with agonist
1) Confidence 0.80 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10762697 Disease Relevance 0 Pain Relevance 0.49
Although NGF alone did not exert a chemotactic effect, its presence enhanced both migration toward fMLP and phosphorylation of MAP kinases (ERK and JNK) in neutrophils from healthy controls, but not in neutrophils from CIPA patients.
Phosphorylation (phosphorylation) of MAP in neutrophils associated with nerve growth factor and hsan
2) Confidence 0.80 Published 2009 Journal Clin. Immunol. Section Abstract Doc Link 18955016 Disease Relevance 0.67 Pain Relevance 0.71
Phosphorylation of mitogen-activated protein (MAP) kinases, upstream kinases, downstream activating transcription factor 2 ATF-2, and caspase-3 processing were evaluated by Western blot. p38 kinase activity was evaluated after immunoprecipitation and phosphorylation of the substrate ATF-2 using Western blot.
Phosphorylation (Phosphorylation) of MAP
3) Confidence 0.80 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18349187 Disease Relevance 0.09 Pain Relevance 0
Occupancy by the agonist DAMGO (Tyr-d-Ala-Gly-N-methyl-Phe-Gly-ol) resulted in phosphorylation of the ERK1/2 MAP kinases, which was blocked by the opioid antagonist naloxone but not the cannabinoid CB1 receptor inverse agonist SR141716A.
Phosphorylation (phosphorylation) of MAP associated with cannabinoid, antagonist, narcan, agonist and opioid
4) Confidence 0.80 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18319252 Disease Relevance 0 Pain Relevance 0.65
Induction of expression of the modified cannabinoid CB1 receptor did not limit DAMGO-mediated ERK1/2 MAP kinase phosphorylation and did not allow SR141716A to enhance the function of DAMGO.
Phosphorylation (phosphorylation) of MAP associated with cannabinoid
5) Confidence 0.80 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18319252 Disease Relevance 0 Pain Relevance 0.64
Acute treatment of DOR cells with DADL caused a 3-fold increase in the level of phosphorylated mitogen-activated protein (MAP) kinase.
Phosphorylation (phosphorylated) of MAP associated with enkephalin and opioid receptor
6) Confidence 0.80 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17159161 Disease Relevance 0 Pain Relevance 1.71
This was accompanied by a decrease in the expressions of SOS and phosphorylated MAP kinases, ERK1 and ERK2, but not FAK or Grab2.
Neg (not) Phosphorylation (phosphorylated) of MAP
7) Confidence 0.80 Published 2004 Journal Med. Sci. Monit. Section Body Doc Link 15173663 Disease Relevance 0 Pain Relevance 0
In contrast, prolonged exposure of HEK293 cells to morphine excited persistent phosphorylation of ERK/MAP kinases, and those cells failed to internalize the opioid receptor.
Phosphorylation (phosphorylation) of MAP associated with opioid receptor and morphine
8) Confidence 0.80 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14742744 Disease Relevance 0 Pain Relevance 0.86
Receptor activation by etorphine turned out to transiently phosphorylate ERK/MAP kinases and bring about DOR internalization within 20 min.
Phosphorylation (phosphorylate) of MAP associated with immobilon
9) Confidence 0.80 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14742744 Disease Relevance 0 Pain Relevance 0.70
Western blot analysis and immunocytochemistry revealed that H2O2 treatment elicited the phosphorylation and nuclear translocation of ERK 1/2 and p38 MAP kinases.
Phosphorylation (phosphorylation) of MAP
10) Confidence 0.80 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11595755 Disease Relevance 0.52 Pain Relevance 0.20
The micro-opioid agonists ([d-ala(2), mephe(4), gly-ol(5)] enkephalin and morphine) promoted the phosphorylation of ERK/MAP kinase within 5 min via G(i/o) protein, calmodulin (CaM), and beta-arrestin2-dependent signaling pathways in immortalized and primary astrocytes.
Phosphorylation (phosphorylation) of MAP in astrocytes associated with mu agonist, enkephalin and morphine
11) Confidence 0.61 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19457093 Disease Relevance 0.08 Pain Relevance 0.79
Phosphorylation of serine residues, including the phosphorylation at Ser505 by MAP kinases, is thought to stabilize membrane binding of the enzyme and enhance its catalytic activity.
Phosphorylation (phosphorylation) of MAP
12) Confidence 0.01 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996791 Disease Relevance 0.26 Pain Relevance 0
In polarized CaCo2 cells, application of PC either from the apical or basolateral site inhibited the phosphorylation and activation of the MAP kinases p38, ERK1 and ERK2.
Phosphorylation (phosphorylation) of MAP
13) Confidence 0.01 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996791 Disease Relevance 0.45 Pain Relevance 0.29

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