INT8765

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1990
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 63
Total Number 65
Disease Relevance 22.28
Pain Relevance 20.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cyp3a23/3a1) endoplasmic reticulum (Cyp3a23/3a1)
Anatomy Link Frequency
hepatocytes 6
liver 4
central nervous system 2
fat 2
1A2 2
Cyp3a23/3a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 802 100.00 Very High Very High Very High
Central nervous system 42 100.00 Very High Very High Very High
diclofenac 12 100.00 Very High Very High Very High
Paracetamol 92 99.98 Very High Very High Very High
Codeine 12 99.62 Very High Very High Very High
Taxol 6 99.32 Very High Very High Very High
Buprenorphine 19 99.26 Very High Very High Very High
withdrawal 7 99.26 Very High Very High Very High
carbamazepine 14 99.20 Very High Very High Very High
cINOD 24 99.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disseminated Intravascular Coagulation 6 100.00 Very High Very High Very High
Rheumatoid Arthritis 331 99.88 Very High Very High Very High
Nicotine Addiction 2 99.84 Very High Very High Very High
Injury 311 99.74 Very High Very High Very High
Adenovirus Infection 7 99.72 Very High Very High Very High
Gallstones 3 99.66 Very High Very High Very High
Necrosis 10 99.40 Very High Very High Very High
Hyperlipidemia 197 99.00 Very High Very High Very High
Toxicity 41 98.92 Very High Very High Very High
Hepatotoxicity 15 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the level present in a modulating concentration (50 mug/ml) of the extract, ginkgolide A (0.55 mug/ml), which increased CYP3A23 mRNA levels and CYP3A-mediated enzyme activity, accounted for part but not all of the potentiating effect of the extract on acetaminophen toxicity.
Positive_regulation (increased) of CYP3A23 associated with toxicity and paracetamol
1) Confidence 0.67 Published 2006 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17045319 Disease Relevance 0.31 Pain Relevance 0.52
These molecules were selected on the basis of their variety of hepatocellular effects observed such as necrosis, cholestasis, steatosis, and induction of CYP P450 enzymes.
Positive_regulation (induction) of CYP associated with necrosis and gallstones
2) Confidence 0.67 Published 2003 Journal Toxicol. Sci. Section Abstract Doc Link 12883083 Disease Relevance 0.20 Pain Relevance 0.09
The results suggest that administration of APAP at a subtoxic dose may result in an induction of hepatic CYP enzymes, thereby altering metabolism and toxicological consequences of various chemical substances that are substrates for the same enzyme system.
Positive_regulation (induction) of CYP associated with paracetamol
3) Confidence 0.67 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19834287 Disease Relevance 0.14 Pain Relevance 1.06
Taxol caused a concentration-dependent increase in the amount of immunoreactive CYP3A and in the steady-state levels of CYP3A1/DEX but not CYP3A2 mRNA.
Positive_regulation (increase) of CYP3A1 associated with taxol
4) Confidence 0.67 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9007036 Disease Relevance 0.33 Pain Relevance 0.71
Overall, gel entrapped hepatocytes showed higher sensitivities to acetaminophen-induced hepatotoxicity than hepatocyte monolayer by a mechanism that higher CYP 2E1 activities of gel entrapped hepatocytes could induce more severe acetaminophen toxicity.
Positive_regulation (induce) of CYP in hepatocytes associated with toxicity, paracetamol and hepatotoxicity
5) Confidence 0.67 Published 2006 Journal Chem. Biol. Interact. Section Abstract Doc Link 16797510 Disease Relevance 0.56 Pain Relevance 0.51
EE treatment also caused an increase in diazepam C3 hydroxylase consistent with an effect to induce P450 IIIA activity but this was found only in microsomes from birth gonadectomized female animals.
Positive_regulation (induce) of P450 IIIA
6) Confidence 0.64 Published 1991 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 1958510 Disease Relevance 0 Pain Relevance 0.08
Pretreatment with rifampicin, an inducer of P-450 IIIA, increased enzyme activity.
Positive_regulation (inducer) of P-450 IIIA
7) Confidence 0.62 Published 1990 Journal Lancet Section Abstract Doc Link 1967328 Disease Relevance 0.16 Pain Relevance 0.08
When the incubation temperature increased from 4°C to 37°C, the Dex releasing rate was greatly increased.
Positive_regulation (increased) of Dex associated with dexamethasone
8) Confidence 0.58 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 0.10 Pain Relevance 0.58
Using hepatic microsomes from rats treated with agents that induce specific CYP isozymes, it was shown that the dexamethasone-inducible rat CYP3A isozyme(s) play a major role in DFH formation.
Positive_regulation (induce) of CYP associated with dexamethasone
9) Confidence 0.49 Published 2001 Journal Drug Metab. Dispos. Section Abstract Doc Link 11159806 Disease Relevance 0.09 Pain Relevance 0.18
It induces the activities of hepatic CYP 1A2, 2B, and 2E1 in rats.
Positive_regulation (induces) of CYP in 1A2
10) Confidence 0.49 Published 2007 Journal Arch. Pharm. Res. Section Abstract Doc Link 18254252 Disease Relevance 0.10 Pain Relevance 0.61
It indicated that In-Chen-How can stimulate the activity of CYP isozymes.
Positive_regulation (stimulate) of CYP
11) Confidence 0.49 Published 2007 Journal Yao Xue Xue Bao Section Abstract Doc Link 17520838 Disease Relevance 0 Pain Relevance 0.47
We investigated the effects on ventilation of 30 mg kg(-1) buprenorphine alone or following cytochrome P450 (CYP) 3A induction with dexamethasone, using whole body plethysmography (N=24) and arterial blood gases (N=12).
Positive_regulation (induction) of CYP in body associated with dexamethasone and buprenorphine
12) Confidence 0.48 Published 2006 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17084876 Disease Relevance 0.23 Pain Relevance 1.21
Among them, a decrease in total P450 in liver microsomes and the loss of CYP3A23 inducibility in PCLS were clearly observed in old rats as compared to adult rats.
Positive_regulation (inducibility) of CYP3A23 in liver
13) Confidence 0.46 Published 2004 Journal Toxicol In Vitro Section Abstract Doc Link 15465655 Disease Relevance 0.18 Pain Relevance 0.25
Arsenic decreased, but acetaminophen increased CYP-dependent enzyme activities.
Positive_regulation (increased) of CYP-dependent associated with paracetamol
14) Confidence 0.45 Published 2010 Journal Food Chem. Toxicol. Section Abstract Doc Link 19932728 Disease Relevance 0.24 Pain Relevance 0.68
The first challenge for this study was how to conjugate Dex to HPMA copolymer.
Positive_regulation (conjugate) of Dex associated with dexamethasone
15) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 1.04 Pain Relevance 0.52
In the present study, we used a pH-sensitive hydrazone bond to conjugate Dex to the HPMA copolymer side chain.
Positive_regulation (conjugate) of Dex associated with dexamethasone
16) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860059 Disease Relevance 0.98 Pain Relevance 0.54
The decline of CYP 3A was partially reversed by CYP inducer PB, and the maximum induction of CYP 3A was 2.2-fold over control after continuous exposure of hepatocytes to 2 mM PB for 48 h.
Positive_regulation (induction) of CYP in hepatocytes
17) Confidence 0.40 Published 2004 Journal Food Chem. Toxicol. Section Abstract Doc Link 15304311 Disease Relevance 0.41 Pain Relevance 0.16
These findings suggest that the hepatotoxicity and metabolism of DF-Na in rat hepatocytes are increased when hepatic CYP 3A activity is increased.
Positive_regulation (increased) of CYP in hepatocytes associated with hepatotoxicity
18) Confidence 0.40 Published 2004 Journal Food Chem. Toxicol. Section Abstract Doc Link 15304311 Disease Relevance 0.17 Pain Relevance 0.04
Ethanol and phenobarbital treatments both increased P450IIIA, as determined immunologically and by the amount of propoxycoumarin depropylase activity that is inhibited by triacetyloleandomycin.
Positive_regulation (increased) of P450IIIA
19) Confidence 0.39 Published 1991 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 1989519 Disease Relevance 0.06 Pain Relevance 0.11
Cytochrome P-450 IIIA was inactivated by about 75% in HEPES and HTK, compared with 55% in UW.
Positive_regulation (inactivated) of Cytochrome P-450 IIIA
20) Confidence 0.36 Published 1995 Journal Transplantation Section Abstract Doc Link 7676491 Disease Relevance 0 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox