INT87650

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Context Info
Confidence 0.67
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 49
Total Number 49
Disease Relevance 22.77
Pain Relevance 8.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (EPHB2)
Anatomy Link Frequency
HGF 2
endothelial cells 2
HeLa 2
plasma 1
chondrocytes 1
EPHB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 257 100.00 Very High Very High Very High
COX2 11 99.56 Very High Very High Very High
Arthritis 118 99.48 Very High Very High Very High
Opioid 7 99.36 Very High Very High Very High
metalloproteinase 85 98.94 Very High Very High Very High
Spinal nerve ligature 6 98.94 Very High Very High Very High
Inflammatory response 24 98.90 Very High Very High Very High
Delta opioid receptors 8 98.76 Very High Very High Very High
Morphine 10 98.64 Very High Very High Very High
Kinase C 46 98.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Osteoarthritis 262 100.00 Very High Very High Very High
Stress 22 100.00 Very High Very High Very High
Arthritis 23 99.48 Very High Very High Very High
Anxiety Disorder 65 99.12 Very High Very High Very High
Ovarian Cancer 680 99.06 Very High Very High Very High
Hypoxia 79 98.96 Very High Very High Very High
INFLAMMATION 428 98.70 Very High Very High Very High
Cancer 1606 98.68 Very High Very High Very High
Apoptosis 297 98.10 Very High Very High Very High
Cirrhosis 66 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the activation of both the p38 and ERK pathways appears to be involved in the AA-induced increase of proENK mRNA via activating the expression of proto-oncoprotein, such as Fra-1, Fra-2, c-Jun, and JunB.
Positive_regulation (activation) of ERK
1) Confidence 0.67 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10762717 Disease Relevance 0 Pain Relevance 0
The finding was also confirmed by the activation of Erk1/2, which was significantly increased in cells from EPOR truncated subjects, grown for 7 days with EPO (Figure 6A).
Positive_regulation (activation) of Erk1
2) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.07 Pain Relevance 0.05
Activation of stress kinase pathways ERK, JNK, and p38 MAPK is a typical feature of chronic synovitis during RA, and several proinflammatory mediators use the signaling of these stress kinase pathways [82].
Positive_regulation (Activation) of ERK associated with stress, synovitis and arthritis
3) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 1.49 Pain Relevance 0.55
However, BT4Cn cells maintained a de-differentiated phenotype, and exhibited an increase in both lamellipodia (Additional file 1, Figure S2 and Table S1) and the cell speed, whereas N2a cells, known to differentiate in response to a sustained increase in Erk1/2 activity [40], consequently demonstrated a decrease in the cell speed when exposed to VPA.
Positive_regulation (increase) of Erk1
4) Confidence 0.67 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0
Signaling through this pathway is often initiated by activation of membrane-localized receptors, leading to activation of the GTPase Ras, and subsequent activation of the MAPK kinase kinase Raf, the MAPK kinases MEK1/2 and the MAPKs Erk1/2 [11].
Positive_regulation (activation) of Erk1
5) Confidence 0.67 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0.90 Pain Relevance 0.24
An L5 SNL induces an immediate (<10 min) but transient (<6 h) induction of phosphoERK (pERK) restricted to neurons in the superficial dorsal horn.
Positive_regulation (induction) of ERK in dorsal horn associated with spinal nerve ligature and dorsal horn
6) Confidence 0.67 Published 2005 Journal Pain Section Abstract Doc Link 15733640 Disease Relevance 0.39 Pain Relevance 1.13
There is evidence highlighting deficits in acute, short-term activation of the MAPK/ERK pathway 30 min after CF training [13].
Positive_regulation (activation) of ERK associated with anxiety disorder
7) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954788 Disease Relevance 0.83 Pain Relevance 0.24
induced pro-inflammatory responses including: (1) assembly of plasma membrane actin; (2) activation of MAP kinases ERK and p38; and (3) activation of NF-?
Positive_regulation (activation) of ERK in plasma associated with inflammatory response
8) Confidence 0.67 Published 2010 Journal International Journal of Molecular Sciences Section Abstract Doc Link PMC2996791 Disease Relevance 0.89 Pain Relevance 0.23
Interestingly, ERK1/2 activation may involve either the classical Ras/Raf/MEK pathway or the activation of the cytosolic, Ca++-dependent tyrosine kinase Pyk2 [11].
Positive_regulation (activation) of ERK1
9) Confidence 0.49 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.62 Pain Relevance 0.11
The EGF induced ERKpp data was taken from HeLa cells [30].
Positive_regulation (induced) of ERK in HeLa
10) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0 Pain Relevance 0
For the ERK1/2 phosphorylation experiments, 50 µg of IgG purified from sera of rats 3 months after immunization and controls were added to the CHO/?
Positive_regulation (experiments) of ERK1 associated with immunization
11) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827566 Disease Relevance 0.32 Pain Relevance 0.20
A similar mechanism was also demonstrated in breast cancer cell lines, showing that estrogen-dependent proliferation involves the synthesis of CXCL12 (identified as estradiol-dependent gene), that causes an autocrine stimulation of CXCR4 and the subsequent activation of c-Src that, in turn, induces a ligand-independent activation of EGFR and ERK1/2 phosphorylation [41].
Neg (independent) Positive_regulation (activation) of ERK1 associated with breast cancer
12) Confidence 0.49 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.84 Pain Relevance 0.21
The finding was also confirmed by the activation of Erk1/2, which was significantly increased in cells from EPOR truncated subjects, grown for 7 days with EPO (Figure 6A).
Positive_regulation (increased) of Erk1
13) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.07 Pain Relevance 0.05
In the presence of minimal amounts EPO, we also found increased Erk1/2 phosphorylation, which suggests greatly augmented activity of the receptor (Figure 6B).
Positive_regulation (increased) of Erk1
14) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.06 Pain Relevance 0.04
This observation is consistent with a previous study in which abrogation of Ras signaling by preventing the farnisylation of the protein did not affect VPA-mediated activation of Erk1/2 in endothelial cells [29].
Positive_regulation (activation) of Erk1 in endothelial cells
15) Confidence 0.49 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0 Pain Relevance 0.04
Activated Erk1/2 phosphorylate targets in the cytosol and transcription factors in the nucleus [12].
Positive_regulation (Activated) of Erk1 in nucleus
16) Confidence 0.49 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0.81 Pain Relevance 0.23
However, the sustained activation of ERK1/2 required both TLR2 and MyD88.
Positive_regulation (activation) of ERK1
17) Confidence 0.49 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2939438 Disease Relevance 0.12 Pain Relevance 0.09
1-integrins, Shc, activated extracellular regulated kinases 1 and 2 (ERK 1/2) and Sox-9.
Positive_regulation (activated) of ERK 1
18) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0 Pain Relevance 0
Further, in these cultures the chondrogenic signalling cascade was activated with high expression of Shc, activated ERK 1/2 and Sox-9.
Positive_regulation (activated) of ERK 1
19) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945017 Disease Relevance 0.05 Pain Relevance 0
More recently, several studies proposed that CXCR4-dependent activation of ERK1/2 was mediated by transactivation of tyrosine kinase receptors.
Positive_regulation (activation) of ERK1
20) Confidence 0.49 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.60 Pain Relevance 0.10

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