INT8766

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Context Info
Confidence 0.49
First Reported 1990
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 3.41
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2B6) endoplasmic reticulum (CYP2B6)
Anatomy Link Frequency
liver 2
hepatocytes 2
CYP2B6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dextromethorphan 8 99.78 Very High Very High Very High
alcohol 14 99.68 Very High Very High Very High
Paracetamol 15 99.22 Very High Very High Very High
carbamazepine 13 99.20 Very High Very High Very High
tolerance 1 98.80 Very High Very High Very High
Codeine 1 97.08 Very High Very High Very High
cytokine 24 96.68 Very High Very High Very High
Trigeminal neuralgia 2 75.00 Quite High
Bile 3 64.24 Quite High
Analgesic 1 63.28 Quite High
Disease Link Frequency Relevance Heat
Cough 1 98.60 Very High Very High Very High
Hepatotoxicity 5 96.72 Very High Very High Very High
Pre-term Labor 37 93.52 High High
Alcohol Addiction 4 92.64 High High
Toxicity 5 91.80 High High
Poisoning 2 91.20 High High
Death 57 86.88 High High
Convulsion 4 86.88 High High
Liver Disease 43 86.16 High High
Premature Birth 10 84.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With the possible exception of the P450IIIA isozyme of the cytochrome P450 family, neither oxcarbazepine nor its monohydroxy derivative induce hepatic oxidative metabolism.
Neg (nor) Positive_regulation (induce) of Neg (exception) Spec (possible) Positive_regulation (exception) of P450
1) Confidence 0.49 Published 1992 Journal Drugs Section Abstract Doc Link 1379159 Disease Relevance 0.61 Pain Relevance 0.36
In addition to ADH, ethanol can be oxidized by liver microsomes: studies over the last 25 years have culiminated in the molecular elucidation of the ethanol-inducible cytochrome P-450 (2E1) which causes metabolic tolerance to ethanol and to various commonly used medications, enhanced degradation of testosterone and vitamin A (with vitamin A depletion) and selective hepatic perivenular toxicity.
Positive_regulation (culiminated) of Positive_regulation (ethanol-inducible) of P-450 in liver associated with toxicity and tolerance
2) Confidence 0.49 Published 1994 Journal Ann. Med. Section Abstract Doc Link 7826592 Disease Relevance 0.25 Pain Relevance 0.16
Metabolism of dextromethorphan in vitro: involvement of cytochromes P450 2D6 and 3A3/4, with a possible role of 2E1.
Spec (possible) Positive_regulation (involvement) of Spec (possible) Positive_regulation (role) of P450 associated with dextromethorphan
3) Confidence 0.49 Published 1997 Journal Biopharm Drug Dispos Section Title Doc Link 9113345 Disease Relevance 0.10 Pain Relevance 0.37
In animals, acute alcohol loading inhibits toxic metabolic activation of paracetamol whilst chronic alcohol administration results in cytochrome P450 (CYP) 2E1 induction with increased toxic metabolic activation of paracetamol by CYP2E1 and increased hepatotoxicity.
Positive_regulation (results) of Positive_regulation (induction) of P450 associated with paracetamol, hepatotoxicity and alcohol
4) Confidence 0.45 Published 2002 Journal Drug Saf Section Abstract Doc Link 12137557 Disease Relevance 0.55 Pain Relevance 0.86
Human hepatocytes maintained in primary cultures for 72 hr in the presence of 50 microM rifampicin exhibited increased levels of P-450IIIA, determined by Western blot using specific antibodies, and concomitant increase in CsA oxidase activity, determined by HPLC analysis of extra and intracellular media.
Positive_regulation (increased) of Positive_regulation (increased) of P-450IIIA in hepatocytes
5) Confidence 0.08 Published 1990 Journal Drug Metab. Dispos. Section Abstract Doc Link 1981707 Disease Relevance 0 Pain Relevance 0
Cortisol leads to activation of p450 dependent placental 17 alpha hydroxylase and 17–20 lyase enzymes to cause conversion of C21 to C18 steroids.56 Maternal estradiol levels rise, and progesterone levels fall, and this change in estrogen: progesterone ratio leads to increased production of prostaglandins (PGs).
Positive_regulation (activation) of Positive_regulation (activation) of p450
6) Confidence 0.07 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2861440 Disease Relevance 0.48 Pain Relevance 0.03
The actual list includes genes encoding cytochrome P450 isoform CYP2E1, alcohol-dehydrogenases (ADHs), and Mn-SOD, as well as a number of cytokines, including TGF?
Positive_regulation (encoding) of Positive_regulation (cytochrome) of P450 associated with cytokine and alcohol
7) Confidence 0.04 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.43 Pain Relevance 0.19

General Comments

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