INT87686

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Context Info
Confidence 0.70
First Reported 2000
Last Reported 2010
Negated 4
Speculated 7
Reported most in Body
Documents 101
Total Number 107
Disease Relevance 72.41
Pain Relevance 69.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) transport (Trpv1) plasma membrane (Trpv1)
transmembrane transport (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
neurons 42
neuronal 10
nerve 6
skin 4
HEK 4
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 2075 100.00 Very High Very High Very High
Pain 1416 100.00 Very High Very High Very High
opioid receptor 1324 100.00 Very High Very High Very High
Spinal cord 210 100.00 Very High Very High Very High
c fibre 151 100.00 Very High Very High Very High
bradykinin 109 100.00 Very High Very High Very High
TRP channel 100 100.00 Very High Very High Very High
Neuropeptide 33 100.00 Very High Very High Very High
Sciatic nerve 26 100.00 Very High Very High Very High
sodium channel 14 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bone Cancer 26 99.98 Very High Very High Very High
Hyperalgesia 1610 99.92 Very High Very High Very High
Hypoalagesia 209 99.88 Very High Very High Very High
Neuropathic Pain 744 99.84 Very High Very High Very High
Disease 188 99.80 Very High Very High Very High
Pain 1358 99.74 Very High Very High Very High
Diabetes Mellitus 1719 99.72 Very High Very High Very High
INFLAMMATION 1362 99.72 Very High Very High Very High
Ganglion Cysts 1398 99.68 Very High Very High Very High
Nociception 501 99.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased expression of vanilloid receptor 1 on myelinated primary afferent neurons contributes to the antihyperalgesic effect of capsaicin cream in diabetic neuropathic pain in mice.
Positive_regulation (Increased) of Gene_expression (expression) of vanilloid receptor 1 in afferent neurons associated with antihyperalgesic, qutenza, diabetes mellitus and neuropathic pain
1) Confidence 0.70 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 12724350 Disease Relevance 0.98 Pain Relevance 1.40
Finally, we confirmed the up-regulation of VR1 expression on myelinated primary afferent neurons of diabetic mice by immunohistochemistry.
Positive_regulation (up-regulation) of Gene_expression (expression) of VR1 in afferent neurons associated with diabetes mellitus
2) Confidence 0.70 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12724350 Disease Relevance 1.07 Pain Relevance 1.47
Here, we report that an up-regulation of VR1 expression on myelinated fibers contributes to the antihyperalgesic effect of capsaicin cream in streptozotocin (STZ)-induced diabetic neuropathic pain.
Positive_regulation (up-regulation) of Gene_expression (expression) of VR1 associated with antihyperalgesic, qutenza, diabetes mellitus and neuropathic pain
3) Confidence 0.70 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12724350 Disease Relevance 0.78 Pain Relevance 0.87
In patch-clamp experiments, capsiate was found to activate TRPV1 expressed transiently in HEK293 cells with a similar potency as capsaicin.
Positive_regulation (activate) of Gene_expression (expressed) of TRPV1 associated with qutenza and potency
4) Confidence 0.70 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12726827 Disease Relevance 0.17 Pain Relevance 0.61
An increase in TRPV1 expression in DRGs occurs as a transient compensatory mechanism to decreased TRPV1-mediated neuronal activity similar to what happens during deafferentation.
Positive_regulation (increase) of Gene_expression (expression) of TRPV1 in neuronal associated with deafferentation
5) Confidence 0.70 Published 2008 Journal Mol Pain Section Body Doc Link PMC2275252 Disease Relevance 1.00 Pain Relevance 0.23
It is possible that an abrupt reduction in insulin levels as occurs in STZ-treated mice could trigger compensatory enhancement of TRPV1 expression resulting in hyperalgesia.
Positive_regulation (enhancement) of Gene_expression (expression) of TRPV1 associated with hyperalgesia
6) Confidence 0.70 Published 2008 Journal Mol Pain Section Body Doc Link PMC2275252 Disease Relevance 0.99 Pain Relevance 0.21
Expression of TRPV1 is elevated in the fibers of the dermis of skin from hyperalgesic diabetic mice and decreased in skin from hypoalgesic mice compared to control non-diabetic mice (Fig. 8A).
Positive_regulation (elevated) of Gene_expression (Expression) of TRPV1 in skin associated with hyperalgesia and diabetes mellitus
7) Confidence 0.70 Published 2008 Journal Mol Pain Section Body Doc Link PMC2275252 Disease Relevance 1.31 Pain Relevance 0.28
In chronic pain conditions, increased TRPV1 expression occurs via MAPK activity [10,55].
Positive_regulation (increased) of Gene_expression (expression) of TRPV1 associated with lasting pain
8) Confidence 0.70 Published 2008 Journal Mol Pain Section Body Doc Link PMC2275252 Disease Relevance 1.43 Pain Relevance 0.42
Furthermore, hyperglycemia is known to induce oxidative stress, as a result a slight increase in ROS is known to activate transcriptional machinery enhancing the expression of TRPV1, at the same time higher levels of ROS can lead to neuronal cell death [45,51,52].
Positive_regulation (enhancing) of Gene_expression (expression) of TRPV1 in neuronal associated with stress, hyperglycemia and death
9) Confidence 0.70 Published 2008 Journal Mol Pain Section Body Doc Link PMC2275252 Disease Relevance 1.21 Pain Relevance 0.28
Oral capsaicin significantly increases transient receptor potential vanilloid type-1 (TRPV1) channel expression as well as TRPV1 messenger ribonucleic acid (mRNA) in visceral adipose tissue.
Positive_regulation (increases) of Gene_expression (expression) of TRPV1 in adipose tissue associated with qutenza and obesity
10) Confidence 0.70 Published 2008 Journal Life Sci. Section Abstract Doc Link 18541272 Disease Relevance 0.76 Pain Relevance 1.20
In this study, we re-evaluated the analgesic effects of pharmacological blockade of TRPV1 using the potent TRPV1 antagonist 5-iodoresiniferatoxin (I-RTX) and examined whether bone cancer can change TRPV1 expression and distribution in the primary sensory neurons in a mouse model of bone cancer pain.
Positive_regulation (change) of Gene_expression (expression) of TRPV1 in primary sensory neurons associated with cancer pain, antagonist, analgesic and bone cancer
11) Confidence 0.69 Published 2007 Journal Neuroscience Section Abstract Doc Link 17656027 Disease Relevance 1.04 Pain Relevance 0.62
In conclusion, TRPV1 activation plays a critical role in the generation of bone cancer pain, and bone cancer increases TRPV1 expression within distinct subpopulation of DRG neurons.
Positive_regulation (increases) of Gene_expression (expression) of TRPV1 in neurons associated with cancer pain and bone cancer
12) Confidence 0.69 Published 2007 Journal Neuroscience Section Abstract Doc Link 17656027 Disease Relevance 0.87 Pain Relevance 0.42
The current finding is also in agreement with our previous observations in mice following nerve injury [35] where we found an increase in TRPV1 expression but no increase in the number of TRPV1 positive cells.
Positive_regulation (increase) of Gene_expression (expression) of TRPV1 in nerve associated with nervous system injury
13) Confidence 0.69 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949725 Disease Relevance 0.40 Pain Relevance 0.08
Given the increased levels of TRPV1 mRNA that were found in the sensory nerve cell bodies, increased TRPV1 expression could result in enhanced TRPV1 protein trafficking to peripheral terminal nociceptors.
Positive_regulation (increased) of Gene_expression (expression) of TRPV1 in nociceptors associated with nociceptor
14) Confidence 0.69 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 1.27 Pain Relevance 0.91
This is generally referred to as peripheral sensitization, although increased expression of TRPV1 at the central terminals of DRG neurons could contribute to central sensitization.
Positive_regulation (increased) of Gene_expression (expression) of TRPV1 in neurons associated with central sensitization and peripheral sensitization
15) Confidence 0.69 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.89 Pain Relevance 0.61
TRPV1 expression is increased in neuropathic pain resulting from nerve lesion [55, 72].
Positive_regulation (increased) of Gene_expression (expression) of TRPV1 in nerve associated with neuropathic pain
16) Confidence 0.69 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 1.06 Pain Relevance 0.84
High concentrations of the 3 terpenoids also activated TRPV1 that was heterologously expressed in HEK293 cells.
Positive_regulation (activated) of Gene_expression (expressed) of TRPV1
17) Confidence 0.69 Published 2009 Journal Life Sci. Section Body Doc Link 19409911 Disease Relevance 0 Pain Relevance 0
It is proposed that up-regulated TRPV1 expression during KM exposure may promote ganglion cell survival by contributing to neuronal depolarization, with KM-induced tinnitus and dizziness as consequences.
Positive_regulation (up-regulated) of Gene_expression (expression) of TRPV1 in ganglion cell associated with tinnitus, ganglion cysts and dizziness
18) Confidence 0.69 Published 2005 Journal Hear. Res. Section Abstract Doc Link 15721568 Disease Relevance 0.37 Pain Relevance 0.15
increases TRPV1 expression through TNF-?
Positive_regulation (increases) of Gene_expression (expression) of TRPV1
19) Confidence 0.68 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.96 Pain Relevance 0.65
There is strong evidence that not only the sensitivity but also the density of expression of VR1 is enhanced during inflammatory conditions.
Positive_regulation (enhanced) of Gene_expression (expression) of VR1 associated with inflammation
20) Confidence 0.67 Published 2002 Journal Curr. Opin. Neurobiol. Section Abstract Doc Link 12139983 Disease Relevance 1.05 Pain Relevance 0.93

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