INT87699

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Context Info
Confidence 0.45
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 5.84
Pain Relevance 8.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (WAS) protein complex assembly (WAS) cytoplasm (WAS)
Anatomy Link Frequency
plasma 1
brain 1
bands 1
urine 1
neural 1
WAS (Homo sapiens)
Pain Link Frequency Relevance Heat
cannabis 383 100.00 Very High Very High Very High
Delta-9-tetrahydrocannabinol 39 100.00 Very High Very High Very High
Analgesic 33 100.00 Very High Very High Very High
Pain 101 99.76 Very High Very High Very High
Nicotine 26 99.64 Very High Very High Very High
cva 6 99.16 Very High Very High Very High
cocaine 112 98.76 Very High Very High Very High
opiate 37 98.52 Very High Very High Very High
Cannabinoid receptor 26 98.28 Very High Very High Very High
Morphine 14 97.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Heparin-induced Thrombocytopenia 2 100.00 Very High Very High Very High
Pain 134 99.76 Very High Very High Very High
Pulmonary Embolism 4 99.56 Very High Very High Very High
Cancer 120 99.28 Very High Very High Very High
INFLAMMATION 40 97.56 Very High Very High Very High
Anaemia 1 96.64 Very High Very High Very High
Myelodysplastic Syndromes 1 96.32 Very High Very High Very High
Breast Cancer 34 94.72 High High
Psychosis 26 93.84 High High
Hypertrophy 1 93.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specifically, nicotine operates through activation of nicotinic acetylcholine receptor (nAChR) complexes; delta9-THC operates through activation of the neural cannabinoid receptor, CB1R.
Positive_regulation (activation) of THC in neural associated with cannabinoid receptor and nicotine
1) Confidence 0.45 Published 2007 Journal BMC Genet Section Body Doc Link PMC1978498 Disease Relevance 0.63 Pain Relevance 1.15
An increase in the amount of THC used in cannabis may have contributed to an increase in the disorders which cause cannabis users to seek medical treatment in the US and many European countries [11] and the use of these cannabis products is particularly common among patients who present with a psychotic disorder [17].
Positive_regulation (increase) of THC associated with cannabis and psychosis
2) Confidence 0.44 Published 2010 Journal BMC Med Section Body Doc Link PMC2922074 Disease Relevance 0.57 Pain Relevance 0.55
Analysis of the results of screening for opiates, cocaine and THC from data provided by CSC for the same time period, shows steady rates of opiate and cocaine detection at maximum and medium levels of security, decreases in opiate and cocaine detection in minimum security, and statistically significant increases in THC detection at all levels of security.
Positive_regulation (increases) of THC associated with opiate and cocaine
3) Confidence 0.39 Published 2000 Journal Can J Public Health Section Abstract Doc Link 10765575 Disease Relevance 0 Pain Relevance 0.44
The discovery of the psychoactive component of cannabis resin, Delta(9)-tetrahydrocannabinol (Delta(9)-THC) occurred long before the serendipitous identification of a G-protein coupled receptor at which Delta(9)-THC is active in the brain.
Positive_regulation (active) of THC in brain associated with cannabis
4) Confidence 0.39 Published 2010 Journal Br. J. Pharmacol. Section Abstract Doc Link 20590559 Disease Relevance 0.28 Pain Relevance 0.53
Using a pressure-driven nebulizer, the pulmonal administration of the THC liquid aerosol resulted in high THC peak plasma levels within minutes.
Positive_regulation (resulted) of THC in plasma associated with delta-9-tetrahydrocannabinol
5) Confidence 0.38 Published 2004 Journal J Pharm Sci Section Abstract Doc Link 15067694 Disease Relevance 0.16 Pain Relevance 0.98
CONCLUSIONS: These studies demonstrate that naltrexone increases the subjective effects of oral THC.
Positive_regulation (increases) of THC
6) Confidence 0.34 Published 2003 Journal Psychopharmacology (Berl.) Section Body Doc Link 12491025 Disease Relevance 0 Pain Relevance 0
Naltrexone tended to increase the reinforcing effects of oral THC (30 mg), as indicated by performance in a drug choice test.
Positive_regulation (increase) of THC
7) Confidence 0.34 Published 2003 Journal Psychopharmacology (Berl.) Section Body Doc Link 12491025 Disease Relevance 0 Pain Relevance 0
[Recombinant hirudine in suspected heparin induced thrombocytopenia--case report of pulmonary embolism].
Positive_regulation (induced) of thrombocytopenia--case associated with pulmonary embolism, heparin-induced thrombocytopenia and cva
8) Confidence 0.29 Published 2000 Journal Pol. Arch. Med. Wewn. Section Title Doc Link 11434091 Disease Relevance 1.28 Pain Relevance 0.28
THC can accumulate in human breast milk to high concentrations [19], and infants exposed to marijuana through their mother's milk will excrete THC in their urine during 2 to 3 weeks [21].
Positive_regulation (accumulate) of THC in urine
9) Confidence 0.24 Published 2009 Journal Journal of Toxicology Section Body Doc Link PMC2809366 Disease Relevance 0.15 Pain Relevance 0.21
It requires emphasis that drug stains of North American (ElSohly et al 2000; Mehmedic et al 2005), and European (King et al 2005) cannabis display relatively high concentrations of THC, but are virtually lacking in CBD or other phytocannabinoid content.


Positive_regulation (concentrations) of THC associated with cannabis
10) Confidence 0.13 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503660 Disease Relevance 0.63 Pain Relevance 1.02
While often touted as a problem, the availability of high THC cannabis with high levels of THC permits less cannabis to be smoked for therapeutic effects.
Positive_regulation (levels) of THC associated with cannabis and delta-9-tetrahydrocannabinol
11) Confidence 0.12 Published 2005 Journal Harm Reduct J Section Body Doc Link PMC1261530 Disease Relevance 0.92 Pain Relevance 0.52
Interestingly, our first knowledge of each pain system has derived from investigation of natural origin analgesic plants, respectively: cannabis (Cannabis sativa, C. indica) (THC, CBD and others), opium poppy (Papaver somniferun) (morphine, codeine), chile peppers (eg, Capsicum annuum, C. frutescens, C. chinense) (capsaicin) and willow bark (Salix spp.)
Positive_regulation (derived) of THC associated with pain, cannabis, qutenza, analgesic, codeine and morphine
12) Confidence 0.12 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503660 Disease Relevance 0.41 Pain Relevance 1.40
Under a progressive-ratio schedule, however, THC dose-dependently increased the number of 50 mug/kg heroin injections self-administered per session and the maximal ratio completed (break-point), with peak increases at 1 mg/kg THC.
Positive_regulation (increases) of THC
13) Confidence 0.06 Published 2005 Journal Neuropsychopharmacology Section Abstract Doc Link 15870833 Disease Relevance 0 Pain Relevance 0.47
Intriguingly, cannabidiol reduces the effect of THC, the main hallucinogenic constituent of cannabis; cannabidiol has antipsychotic properties [37], but the THC content is increased and the cannabidiol content is reduced in currently available street cannabis compared to ten years ago [7].
Positive_regulation (increased) of THC associated with cannabis
14) Confidence 0.05 Published 2010 Journal BMC Psychiatry Section Body Doc Link PMC2999587 Disease Relevance 0 Pain Relevance 0.26
We observed a decrease in Akt activation in THC-treated MMTV-neu tumors (Fig. 5B) as well as diminished levels of phosphorylated S6 ribosomal protein [a read-out for activation of the Akt/mammalian target of rapamycin (mTOR) pathway [12]] (Fig. 5C).
Positive_regulation (activation) of THC associated with cancer
15) Confidence 0.04 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2917429 Disease Relevance 0.58 Pain Relevance 0.20
A second finding was that the voltage (not relative power or coherence) of all non-alpha frequency bands was significantly elevated in THC users, although the voltage increase was generalized and not frontally dominant.
Positive_regulation (elevated) of THC in bands
16) Confidence 0.03 Published 2008 Journal Appl Psychophysiol Biofeedback Section Body Doc Link PMC2259255 Disease Relevance 0.23 Pain Relevance 0.04

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