INT8772

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Context Info
Confidence 0.68
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 6.93
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HBG1) transport (HBG1)
Anatomy Link Frequency
platelet 3
lymphocyte 2
neutrophils 2
leukocyte 1
HBG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 4 99.42 Very High Very High Very High
Analgesic 3 98.98 Very High Very High Very High
Pain 24 97.56 Very High Very High Very High
palliative 1 91.44 High High
imagery 11 91.04 High High
agonist 6 50.00 Quite Low
Inflammatory response 1 10.76 Low Low
Potency 15 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 156 99.44 Very High Very High Very High
INFLAMMATION 5 99.42 Very High Very High Very High
Acute Erythroblastic Leukemia 1 99.38 Very High Very High Very High
Sickle Cell Anemia 33 99.28 Very High Very High Very High
Disease 32 99.16 Very High Very High Very High
Hemoglobinopathy 6 99.08 Very High Very High Very High
Pain 18 97.52 Very High Very High Very High
Anaemia 8 95.92 Very High Very High Very High
Granuloma 1 91.92 High High
Splenomegaly 2 91.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several pharmacologic agents such as 5-azacytidine, myleran, hydroxyurea, erthropoietin, and butyrates enhance fetal hemoglobin production and have been used in hemoglobinopathy patients to ameliorate severe pain episodes and reduce severe anemia.
Positive_regulation (enhance) of Gene_expression (production) of hemoglobin associated with pain, hemoglobinopathy and anaemia
1) Confidence 0.68 Published 2001 Journal Pediatr Pathol Mol Med Section Abstract Doc Link 12673846 Disease Relevance 0.29 Pain Relevance 0.10
One of the primary cellular mechanisms involved in pharmacologic induction of Hb F synthesis is rapid regeneration of erythroid precursors following the cytoreduction phase of certain pharmacologic agents.
Positive_regulation (induction) of Gene_expression (synthesis) of Hb F
2) Confidence 0.68 Published 2001 Journal Pediatr Pathol Mol Med Section Abstract Doc Link 12673846 Disease Relevance 0.28 Pain Relevance 0.09
Pharmacologic induction of fetal hemoglobin synthesis: cellular and molecular mechanisms.
Positive_regulation (induction) of Gene_expression (synthesis) of hemoglobin
3) Confidence 0.68 Published 2001 Journal Pediatr Pathol Mol Med Section Title Doc Link 12673846 Disease Relevance 0.25 Pain Relevance 0.08
This study confirms that hydroxyurea therapy increases Hb F production and provides objective evidence of a significant reduction in hemolytic rate and intracellular polymerization.
Positive_regulation (increases) of Gene_expression (production) of Hb F
4) Confidence 0.45 Published 1992 Journal Semin. Oncol. Section Abstract Doc Link 1379376 Disease Relevance 0.21 Pain Relevance 0.10
Hydroxyurea has been shown to increase fetal hemoglobin (Hb F) production in patients with sickle cell disease and therefore has the potential to alleviate both the hemolytic and vaso-occlusive manifestations of the disease.
Positive_regulation (increase) of Gene_expression (production) of hemoglobin associated with sickle cell anemia and disease
5) Confidence 0.39 Published 1992 Journal Semin. Oncol. Section Abstract Doc Link 1379376 Disease Relevance 0.35 Pain Relevance 0
pO2 in tumors was lower in patients with higher hemoglobin levels after session #1 (rho = ?
Positive_regulation (higher) of Gene_expression (levels) of hemoglobin associated with cancer
6) Confidence 0.39 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC442111 Disease Relevance 0.52 Pain Relevance 0
Laboratory tests showed a hemoglobin level of 10.3 g/dL, a leukocyte level of 6,900/mm(3), with an increased proportion of segmented nuclear neutrophils (83%), and an elevated C-reactive protein.
Positive_regulation (showed) of Gene_expression (level) of hemoglobin in neutrophils
7) Confidence 0.34 Published 2006 Journal Int. J. Dermatol. Section Abstract Doc Link 16650178 Disease Relevance 0.91 Pain Relevance 0.10
Hydroxyurea has been shown to increase fetal hemoglobin (Hb F) production in patients with sickle cell disease and therefore has the potential to alleviate both the hemolytic and vaso-occlusive manifestations of the disease.
Positive_regulation (increase) of Gene_expression (production) of Hb F associated with sickle cell anemia and disease
8) Confidence 0.33 Published 1992 Journal Semin. Oncol. Section Abstract Doc Link 1379376 Disease Relevance 0.35 Pain Relevance 0
During ERT, clinical abnormality rates decreased (except for neurological involvement) and the biological data improved overall during ERT (increased hemoglobin, leukocyte and platelet levels; decreased chitotriosidase, ACE, TRAP, ferritin and gammaglobulin levels).
Positive_regulation (increased) of Gene_expression (levels) of hemoglobin in platelet
9) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 0.27 Pain Relevance 0
erythroleukemia cells showed a dose-dependent increase in hemoglobin synthesis.
Positive_regulation (increase) of Gene_expression (synthesis) of hemoglobin associated with acute erythroblastic leukemia
10) Confidence 0.03 Published 2008 Journal PPAR Research Section Body Doc Link PMC2464819 Disease Relevance 0.34 Pain Relevance 0
Elaborate hematological investigations with electrolyte levels were done which revealed an increase in lymphocyte, ESR rate and hemoglobin level.
Positive_regulation (increase) of Gene_expression (level) of hemoglobin in lymphocyte
11) Confidence 0.03 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC3020523 Disease Relevance 0.82 Pain Relevance 0.11
The -158 (C-->T) polymorphism of the (G)gamma-globin gene (XmnI polymorphism) is known to ameliorate the severity of the disease because of it strong association with an increased production of fetal hemoglobin (Hb F).
Positive_regulation (increased) of Gene_expression (production) of Hb F associated with disease
12) Confidence 0.02 Published 2007 Journal Hemoglobin Section Abstract Doc Link 17486495 Disease Relevance 0.42 Pain Relevance 0.09
The average gamma-globin synthesis relative to non-alpha-globin synthesis prior to therapy was 3.19% +/- 1.43% and increased to 13.66% +/- 4.35% after treatment.
Positive_regulation (increased) of Gene_expression (synthesis) of gamma-globin
13) Confidence 0.02 Published 2000 Journal Blood Section Abstract Doc Link 11001887 Disease Relevance 0.31 Pain Relevance 0.08
During ERT, clinical abnormality rates decreased (except for neurological involvement) and the biological data improved overall during ERT (increased hemoglobin, leukocyte and platelet levels; decreased chitotriosidase, ACE, TRAP, ferritin and gammaglobulin levels).
Positive_regulation (increased) of in leukocyte Gene_expression (levels) of hemoglobin in platelet
14) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 0.27 Pain Relevance 0
These compounds 1–6 have presented an analgesic and anti-inflammatory profile and the capacity to stimulate the gamma globin RNAm synthesis using K562 cells [6].
Positive_regulation (stimulate) of Gene_expression (synthesis) of gamma globin associated with inflammation and analgesic
15) Confidence 0.01 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852868 Disease Relevance 0.30 Pain Relevance 0.21
In the latter patients, HU alleviates the classical symptoms of the SCD not by its anti-mitotic effect but by provoking increased production of fetal hemoglobin which has a higher oxygen carrying capacity than sickle cell hemoglobin.
Neg (not) Positive_regulation (increased) of Gene_expression (production) of hemoglobin associated with sickle cell anemia
16) Confidence 0.01 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2898034 Disease Relevance 1.05 Pain Relevance 0

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