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Context Info
Confidence 0.25
First Reported 2000
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.10
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Ddc) intracellular (Ddc) cellular amino acid metabolic process (Ddc)
cytoplasm (Ddc)
Anatomy Link Frequency
nerve 2
striatum 2
Ddc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 3 100.00 Very High Very High Very High
Dopamine 20 98.92 Very High Very High Very High
withdrawal 4 98.52 Very High Very High Very High
agonist 1 89.08 High High
adenocard 3 76.08 Quite High
antagonist 3 75.00 Quite High
cINOD 1 72.48 Quite High
addiction 2 34.52 Quite Low
Enkephalin 2 25.00 Low Low
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 5 98.92 Very High Very High Very High
Pheochromocytoma 3 89.56 High High
Dyskinesias 9 89.20 High High
INFLAMMATION 1 71.04 Quite High
Urological Neuroanatomy 8 50.00 Quite Low
Osteogenic Sarcomas 2 46.00 Quite Low
Disease 24 5.00 Very Low Very Low Very Low
Stress 13 5.00 Very Low Very Low Very Low
Death 9 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to Camk1g, the microarray dose-response cohort demonstrated a dose-related change in Ddc expression for deltamethrin only, even though a clear dose-dependent decrease in Ddc mRNA expression was observed in both the deltamethrin and permethrin qRT-PCR cohorts.
Regulation (change) of Gene_expression (expression) of Ddc
1) Confidence 0.25 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0 Pain Relevance 0
In situ hybridization histochemistry showed that KW-6002 treatment alone caused an approximately 20% reduction in the striatal levels of preproenkephalin mRNA, whereas neither the coadministration of KW-6002 and L-DOPA nor L-DOPA alone significantly altered the expression of this transcript in the dopamine-denervated striatum.
Neg (nor) Regulation (altered) of Gene_expression (expression) of L-DOPA in striatum associated with dopamine
2) Confidence 0.22 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12614340 Disease Relevance 0.43 Pain Relevance 0.27
Cox-2 bioactivity had no effect on nerve growth factor-induced differentiation, epidermal growth factor-induced proliferation, or aromatic L-amino acid decarboxylase expression.
Neg (no) Regulation (effect) of Gene_expression (expression) of L-amino acid decarboxylase in nerve associated with nerve growth factor
3) Confidence 0.20 Published 2000 Journal J. Biol. Chem. Section Abstract Doc Link 10766843 Disease Relevance 0.67 Pain Relevance 0.41
In vivo modulation of L-DOPA methylation
Regulation (modulation) of Gene_expression (methylation) of L-DOPA
4) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916818 Disease Relevance 0 Pain Relevance 0.03

General Comments

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