INT8773

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Context Info
Confidence 0.76
First Reported 1988
Last Reported 2011
Negated 1
Speculated 1
Reported most in Abstract
Documents 58
Total Number 59
Disease Relevance 37.60
Pain Relevance 4.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HBG1) transport (HBG1)
Anatomy Link Frequency
blood 6
leukocytes 5
plasma 2
neutrophil 2
erythrocyte 1
HBG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 79 100.00 Very High Very High Very High
anesthesia 19 99.96 Very High Very High Very High
abdominal pain 5 99.88 Very High Very High Very High
Inflammation 67 99.14 Very High Very High Very High
Analgesic 6 98.70 Very High Very High Very High
Paracetamol 13 97.96 Very High Very High Very High
ischemia 14 97.14 Very High Very High Very High
colic 4 96.96 Very High Very High Very High
Catecholamine 1 92.32 High High
headache 13 92.16 High High
Disease Link Frequency Relevance Heat
Pain 67 100.00 Very High Very High Very High
Hemolysis 66 100.00 Very High Very High Very High
Confusion 4 100.00 Very High Very High Very High
Pneumonia 153 99.98 Very High Very High Very High
Anaemia 556 99.92 Very High Very High Very High
Abdominal Pain 5 99.88 Very High Very High Very High
Pressure Volume 2 Under Development 29 99.76 Very High Very High Very High
Disease 203 99.52 Very High Very High Very High
Gastrointestinal Hemorrhage 3 99.50 Very High Very High Very High
Cancer 389 99.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several pharmacologic agents such as 5-azacytidine, myleran, hydroxyurea, erthropoietin, and butyrates enhance fetal hemoglobin production and have been used in hemoglobinopathy patients to ameliorate severe pain episodes and reduce severe anemia.
Gene_expression (production) of hemoglobin associated with pain, hemoglobinopathy and anaemia
1) Confidence 0.76 Published 2001 Journal Pediatr Pathol Mol Med Section Abstract Doc Link 12673846 Disease Relevance 0.29 Pain Relevance 0.10
The switch from embryonic to fetal then to adult hemoglobin synthesis is a unique phenomenon during early human development.
Gene_expression (synthesis) of hemoglobin
2) Confidence 0.76 Published 2001 Journal Pediatr Pathol Mol Med Section Abstract Doc Link 12673846 Disease Relevance 0.22 Pain Relevance 0.07
Pharmacologic induction of fetal hemoglobin synthesis: cellular and molecular mechanisms.
Gene_expression (synthesis) of hemoglobin
3) Confidence 0.76 Published 2001 Journal Pediatr Pathol Mol Med Section Title Doc Link 12673846 Disease Relevance 0.25 Pain Relevance 0.08
One of the primary cellular mechanisms involved in pharmacologic induction of Hb F synthesis is rapid regeneration of erythroid precursors following the cytoreduction phase of certain pharmacologic agents.
Gene_expression (synthesis) of Hb F
4) Confidence 0.76 Published 2001 Journal Pediatr Pathol Mol Med Section Abstract Doc Link 12673846 Disease Relevance 0.27 Pain Relevance 0.09
Laboratory tests were mildly abnormal for liver function, leukocytes, and hemoglobin; these reactions were significant enough to be considered adverse drug experiences only occasionally.
Gene_expression (abnormal) of hemoglobin in leukocytes
5) Confidence 0.66 Published 1989 Journal Cardiology Section Abstract Doc Link 2673510 Disease Relevance 0.56 Pain Relevance 0.08
Detection of total protein and human hemoglobin in residual anesthetic solution].
Gene_expression (Detection) of hemoglobin
6) Confidence 0.65 Published 1988 Journal Nippon Shishubyo Gakkai Kaishi Section Title Doc Link 3270661 Disease Relevance 0 Pain Relevance 0.28
Massive GI bleeding in a patient with 2 small AVMs in the small intestine: a case report

A 53 year-old Caucasian man with no previous history of gastrointestinal bleeding presented with sudden, massive hematochezia and abdominal pain; his hemoglobin dropped from 12 to 8.3.

Gene_expression (dropped) of hemoglobin in small intestine associated with abdominal pain, gastrointestinal hemorrhage and hemorrhage
7) Confidence 0.62 Published 2010 Journal Cases J Section Title Doc Link PMC2827382 Disease Relevance 1.02 Pain Relevance 0.10
The World Health Organization defines anemia as hemoglobin levels <13 g/dL in men or <12 g/dL in women [21].
Gene_expression (levels) of hemoglobin associated with anaemia
8) Confidence 0.57 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2848211 Disease Relevance 0.76 Pain Relevance 0.10
Because we wished to explore the prevalence and significance of anemia of varying degrees of severity, we classified anemia based on hemoglobin values into categories consisting of no anemia (>13 g/dL), at least borderline (?
Gene_expression (values) of hemoglobin associated with anaemia
9) Confidence 0.57 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2848211 Disease Relevance 0.89 Pain Relevance 0.09
The World Health Organization defines anemia as hemoglobin levels <13 g/dL in men or <12 g/dL in women [21].
Gene_expression (levels) of hemoglobin associated with anaemia
10) Confidence 0.57 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2848211 Disease Relevance 1.22 Pain Relevance 0
pO2 in tumors was lower in patients with higher hemoglobin levels after session #1 (rho = ?
Gene_expression (levels) of hemoglobin associated with cancer
11) Confidence 0.53 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC442111 Disease Relevance 0.52 Pain Relevance 0
His hemoglobin levels dropped to 5.7 mg/dL without showing bloody stools.
Gene_expression (levels) of hemoglobin
12) Confidence 0.53 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2987965 Disease Relevance 1.24 Pain Relevance 0.44
pO2 and hemoglobin levels was found.
Gene_expression (levels) of hemoglobin
13) Confidence 0.53 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC442111 Disease Relevance 0.52 Pain Relevance 0
Hydroxyurea has been shown to increase fetal hemoglobin (Hb F) production in patients with sickle cell disease and therefore has the potential to alleviate both the hemolytic and vaso-occlusive manifestations of the disease.
Gene_expression (production) of Hb F associated with sickle cell anemia and disease
14) Confidence 0.50 Published 1992 Journal Semin. Oncol. Section Abstract Doc Link 1379376 Disease Relevance 0.35 Pain Relevance 0
This study confirms that hydroxyurea therapy increases Hb F production and provides objective evidence of a significant reduction in hemolytic rate and intracellular polymerization.
Gene_expression (production) of Hb F
15) Confidence 0.50 Published 1992 Journal Semin. Oncol. Section Abstract Doc Link 1379376 Disease Relevance 0.21 Pain Relevance 0.10
We did not have access to pre-CAP hemoglobin levels, and were therefore unable to determine if anemia preceded the development of pneumonia.
Gene_expression (levels) of hemoglobin associated with anaemia and pneumonia
16) Confidence 0.50 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2848211 Disease Relevance 1.74 Pain Relevance 0.15
Laboratory tests showed a hemoglobin level of 10.3 g/dL, a leukocyte level of 6,900/mm(3), with an increased proportion of segmented nuclear neutrophils (83%), and an elevated C-reactive protein.
Gene_expression (level) of hemoglobin in neutrophils
17) Confidence 0.46 Published 2006 Journal Int. J. Dermatol. Section Abstract Doc Link 16650178 Disease Relevance 0.91 Pain Relevance 0.10
Hydroxyurea has been shown to increase fetal hemoglobin (Hb F) production in patients with sickle cell disease and therefore has the potential to alleviate both the hemolytic and vaso-occlusive manifestations of the disease.
Gene_expression (production) of hemoglobin associated with sickle cell anemia and disease
18) Confidence 0.44 Published 1992 Journal Semin. Oncol. Section Abstract Doc Link 1379376 Disease Relevance 0.35 Pain Relevance 0
The left middle finger was then placed on the detection probe of the device, and hemoglobin levels, venous blood vessel width, and VOI were automatically determined.
Gene_expression (levels) of hemoglobin in venous blood vessel
19) Confidence 0.37 Published 2007 Journal Biopsychosoc Med Section Body Doc Link PMC1851706 Disease Relevance 0.20 Pain Relevance 0.05
No difference was found between the groups in the immediate postoperative levels of hemoglobin and hematocrite.
Gene_expression (levels) of hemoglobin
20) Confidence 0.24 Published 2010 Journal BMC Anesthesiol Section Abstract Doc Link PMC2891743 Disease Relevance 0.73 Pain Relevance 0.03

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