INT87734

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Context Info
Confidence 0.23
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 2.44
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ARAF) protein modification process (ARAF) mitochondrion (ARAF)
cellular_component (ARAF)
ARAF (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 33 98.36 Very High Very High Very High
Opioid 1 97.12 Very High Very High Very High
adenocard 6 96.08 Very High Very High Very High
gABA 2 95.16 Very High Very High Very High
sodium channel 1 86.68 High High
Arthritis 2 79.20 Quite High
imagery 1 77.08 Quite High
Pain 5 75.00 Quite High
Neuropathic pain 3 43.00 Quite Low
Migraine 3 42.16 Quite Low
Disease Link Frequency Relevance Heat
Cancer 65 99.28 Very High Very High Very High
Disease 34 97.80 Very High Very High Very High
Apoptosis 13 94.56 High High
Glioma 18 92.48 High High
Arthritis 1 79.20 Quite High
Increased Venous Pressure Under Development 1 78.64 Quite High
Neuroblastoma 3 78.24 Quite High
Adenocarcinoma 7 75.12 Quite High
Pain 4 75.00 Quite High
Toxicity 9 63.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, when the radiopharmaceutical is assumed to be uniformly distributed in the bone volume, the RAF values for these 7 radionuclides were 1.1, 1.5, 2.4, 3.2, 4.5, 5.1, and 6.5, respectively.
Regulation (values) of RAF
1) Confidence 0.23 Published 2000 Journal J. Nucl. Med. Section Abstract Doc Link 10768569 Disease Relevance 0.07 Pain Relevance 0.14
Therefore, targeting raf seems to be an attractive option for the treatment of diseases associated with abnormal cell proliferation.
Regulation (targeting) of raf associated with disease
2) Confidence 0.04 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 0.61 Pain Relevance 0
Furthermore, cells express up to three Raf types (i.e., A-, B- and c-Raf), which are affected differently by upstream targets, thereby adding a further level of complexity to MAPK-mediated signaling [13,14].
Regulation (affected) of Raf
3) Confidence 0.04 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0.49 Pain Relevance 0.12
In contrast, modulation of cell growth and motility was in some cell lines related to changes in the degree of Erk1/2 phosphorylation, which was regulated at the level of Raf.


Regulation (regulated) of Raf
4) Confidence 0.02 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0.47 Pain Relevance 0.03
Furthermore, cells express up to three Raf types (i.e., A-, B- and c-Raf), which are affected differently by upstream targets, thereby adding a further level of complexity to MAPK-mediated signaling [13,14].
Regulation (affected) of Raf
5) Confidence 0.02 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0.38 Pain Relevance 0.12
The randomly chosen drug targets were not skewed towards peptide receptors and included: squalene epoxidase, RAF proto-oncogene serine/threonine-protein kinase, muscarinic acetylcholine receptor M4, opioid mu receptor (OP3), adenosine A1 receptor, GABA transaminase, amidophosphoribosyltransferase precursor, tryptophan 5-hydroxylase 1, apoptosis regulator Bcl-2, matrix protein M2, vascular endothelial growth factor receptor 2 precursor, amiloride-sensitive sodium channel gamma-subunit, ribonucleotide reductase, cAMP phosphodiesterase, coagulation factor VIII, high affinity immunoglobulin epsilon receptor alpha-subunit precursor, retinol-binding protein I, glycine alpha 2 receptor, cytochrome P450 51, GABA-A receptor subunit (C. elegans).
Regulation (targets) of RAF proto-oncogene associated with gaba, adenocard, sodium channel, apoptosis and opioid
6) Confidence 0.02 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1976427 Disease Relevance 0.41 Pain Relevance 0.35

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