INT8775

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Context Info
Confidence 0.48
First Reported 1983
Last Reported 2010
Negated 7
Speculated 2
Reported most in Abstract
Documents 167
Total Number 169
Disease Relevance 102.61
Pain Relevance 23.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
mast cells 24
basophils 8
immune system 4
muscle 4
eosinophils 4
IGHE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 47 99.78 Very High Very High Very High
Morphine 47 99.76 Very High Very High Very High
Arthritis 108 99.64 Very High Very High Very High
alcohol 19 99.60 Very High Very High Very High
Inflammation 820 99.58 Very High Very High Very High
diclofenac 561 99.58 Very High Very High Very High
methadone 4 99.40 Very High Very High Very High
Mexiletine 3 99.36 Very High Very High Very High
corticosteroid 512 99.28 Very High Very High Very High
Codeine 30 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypersensitivity 1632 100.00 Very High Very High Very High
Syndrome 266 100.00 Very High Very High Very High
Eosinophilia 155 100.00 Very High Very High Very High
Gastroenteritis 41 100.00 Very High Very High Very High
Acute Coronary Syndrome 4 100.00 Very High Very High Very High
Asthma 3375 99.98 Very High Very High Very High
Solid Tumor 6 99.84 Very High Very High Very High
Helminth Infection 151 99.80 Very High Very High Very High
Anaphylactic Hypersensitivity 7 99.78 Very High Very High Very High
Hematological Disease 6 99.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IgE antibodies that bind the muscle relaxant alcuronium were found in sera from six patients who experienced anaphylactic-like reactions following administration of the drug during induction of anaesthesia.
IgE Binding (bind) of in muscle associated with anaphylaxis
1) Confidence 0.48 Published 1983 Journal Mol. Immunol. Section Abstract Doc Link 6656781 Disease Relevance 0.17 Pain Relevance 0
Anaphylaxis to muscle relaxant drugs: cross-reactivity and molecular basis of binding of IgE antibodies detected by radioimmunoassay.
IgE Binding (binding) of in muscle associated with anaphylaxis
2) Confidence 0.48 Published 1983 Journal Mol. Immunol. Section Title Doc Link 6656781 Disease Relevance 0.19 Pain Relevance 0.07
Omalizumab (Xolair®, Novartis Pharma AG) is a recombinant DNA-derived humanized immunoglobulin G (IgG) 1k monoclonal antibody that selectively binds to human immunoglobulin E (IgE) and has been developed for the treatment of allergic asthma.
IgE Binding (binds) of associated with asthma
3) Confidence 0.48 Published 2008 Journal Core Evidence Section Body Doc Link PMC2899803 Disease Relevance 0.35 Pain Relevance 0.06
Allergic sensitization results from the formation of specific IgE in response to common inhaled allergens such as pollen and house dust mites.
IgE Binding (formation) of in pollen associated with hypersensitivity
4) Confidence 0.48 Published 2008 Journal Core Evidence Section Body Doc Link PMC2899803 Disease Relevance 1.37 Pain Relevance 0.16
It binds to IgE at the high affinity IgE receptor-binding site, forming immune complexes with free IgE (Presta et al. 1993).
IgE Binding (binds) of
5) Confidence 0.48 Published 2008 Journal Core Evidence Section Body Doc Link PMC2899803 Disease Relevance 0.46 Pain Relevance 0.08
Hapten inhibition studies with morphine and a number of structurally-related analogues revealed that morphine and codeine were the most potent inhibitors of IgE binding to a morphine-solid phase.
IgE Binding (binding) of associated with codeine and morphine
6) Confidence 0.48 Published 1989 Journal Anesthesiology Section Abstract Doc Link 2478047 Disease Relevance 0.17 Pain Relevance 1.04
Nalorphine, meperidine, and methadone were also good inhibitors of IgE binding, but naltrexone, buprenorphine, and fentanyl proved to be poor inhibitors.
IgE Binding (binding) of associated with methadone and buprenorphine
7) Confidence 0.48 Published 1989 Journal Anesthesiology Section Abstract Doc Link 2478047 Disease Relevance 0.16 Pain Relevance 1.04
Postnatal maternal use was associated with asthma and wheezing, though less strongly than was prenatal use, and was not associated with IgE.
IgE Binding (associated) of
8) Confidence 0.45 Published 2010 Journal Int J Epidemiol Section Body Doc Link 20356852 Disease Relevance 0 Pain Relevance 0
Partner's use was very weakly associated with asthma but not associated with wheezing or IgE.
IgE Binding (associated) of
9) Confidence 0.45 Published 2010 Journal Int J Epidemiol Section Body Doc Link 20356852 Disease Relevance 0 Pain Relevance 0
BACKGROUND: Neuromuscular blocking agents (NMBAs) can cause anaphylaxis through immunoglobulin E (IgE) antibodies that bind quaternary ammonium ion epitopes.
IgE Binding (bind) of associated with anaphylaxis
10) Confidence 0.45 Published 2007 Journal Allergy Section Abstract Doc Link 17983379 Disease Relevance 0.26 Pain Relevance 0
After studying control samples, where equal volumes of PBS were preincubated instead of inhibitors, the inhibition of the specific IgE binding was expressed as: 100- (absorbance of samples preincubated with allergens/absorbance of samples preincubated with PBS) ×100 (%).


IgE Binding (binding) of
11) Confidence 0.42 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526437 Disease Relevance 0.05 Pain Relevance 0
Flow-cytometric analysis of mononuclear cells isolated from peripheral blood showed that 15% of the lymphocytes bound IgE.
IgE Binding (bound) of in mononuclear cells
12) Confidence 0.40 Published 1992 Journal Clin. Chem. Section Abstract Doc Link 1424132 Disease Relevance 0.32 Pain Relevance 0.07
However, the recent progress in the identification of drug epitopes by Sepharose-solid drug phase IgE radioimmunoassay has to be reconsidered as non-specific binding of hydrophobic drugs such as propofol to hydrophobic serum IgE has been observed recently in patients with drug allergy.
IgE Binding (binding) of associated with drug hypersensitivity
13) Confidence 0.38 Published 1998 Journal Clin. Exp. Allergy Section Abstract Doc Link 9761037 Disease Relevance 0.42 Pain Relevance 0.13
Inhibition of IgE binding by monoethylene-glycol showed that the cross-reactivity was due to hydrophobic binding of IgE to the drug.
IgE Binding (binding) of
14) Confidence 0.38 Published 1995 Journal Mol. Immunol. Section Abstract Doc Link 7723771 Disease Relevance 0.26 Pain Relevance 0.24
Inhibition of IgE binding by monoethylene-glycol showed that the cross-reactivity was due to hydrophobic binding of IgE to the drug.
IgE Binding (binding) of
15) Confidence 0.38 Published 1995 Journal Mol. Immunol. Section Abstract Doc Link 7723771 Disease Relevance 0.26 Pain Relevance 0.23
As basophils have been recently shown to be key players in the immune system [32], we investigated DF/DF5der/DF-metabolite-specific IgE bound on patients' basophils by BAT and sLT production.
IgE Binding (bound) of in immune system associated with diclofenac
16) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965666 Disease Relevance 0.27 Pain Relevance 0.36
Drug-specific antibodies were detected by radioimmunoassay employing a covalently coupled alcuronium-Sepharose complex and 125I-labelled anti-human IgE.
IgE Binding (complex) of
17) Confidence 0.37 Published 1983 Journal Mol. Immunol. Section Abstract Doc Link 6656781 Disease Relevance 0.17 Pain Relevance 0.06
IgE antibodies in the other sera cross-reacted with the muscle relaxants, other quaternary ammonium compounds and some pharmacologically unrelated drugs including promethazine, morphine, neostigmine and pentolineum.
IgE Binding (cross-reacted) of in muscle associated with morphine
18) Confidence 0.37 Published 1983 Journal Mol. Immunol. Section Abstract Doc Link 6656781 Disease Relevance 0.15 Pain Relevance 0.09
It binds to IgE at the high affinity IgE receptor-binding site, forming immune complexes with free IgE (Presta et al. 1993).
IgE Binding (complexes) of
19) Confidence 0.37 Published 2008 Journal Core Evidence Section Body Doc Link PMC2899803 Disease Relevance 0.46 Pain Relevance 0.08
The similarity of the spectrotype of this monoclonal IgE to that of two purified monoclonal IgEs suggests that these proteins have a characteristic spectrotype, sufficiently different from those of other immunoglobulin classes to allow its recognition.
IgE Binding (recognition) of
20) Confidence 0.37 Published 1988 Journal Clin. Chem. Section Abstract Doc Link 2971476 Disease Relevance 0.18 Pain Relevance 0.09

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