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Context Info
Confidence 0.11
First Reported 2000
Last Reported 2005
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.86
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IGFBP3, INS) extracellular region (IGFBP3, INS) small molecule metabolic process (INS)
nucleus (IGFBP3) carbohydrate metabolic process (INS) cell-cell signaling (INS)
IGFBP3 (Homo sapiens)
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 93.64 High High
headache 1 69.12 Quite High
Disease Link Frequency Relevance Heat
Arthralgia 1 94.28 High High
Pain 2 93.64 High High
Pressure And Volume Under Development 2 93.24 High High
Body Weight 1 86.08 High High
Diabetes Mellitus 8 75.00 Quite High
Headache 1 69.12 Quite High
Papilledema 1 67.52 Quite High
Paralysis 1 65.52 Quite High
Hyperglycemia 1 25.44 Quite Low
Insulin Resistance 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To analyze the mechanism by which IGF-I/IGFBP-3 might reduce insulin requirements, the change in serum GH was quantified.
IGFBP-3 Spec (might) Negative_regulation (reduce) of insulin
1) Confidence 0.11 Published 2000 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10770191 Disease Relevance 0.50 Pain Relevance 0.14
We conclude that rhIGF-I/rhIGFBP-3 significantly lowers insulin requirements yet improves glucose values and these changes may reflect improvement in insulin sensitivity.
rhIGFBP-3 Negative_regulation (lowers) of insulin
2) Confidence 0.10 Published 2005 Journal Growth Horm. IGF Res. Section Abstract Doc Link 16005252 Disease Relevance 0.36 Pain Relevance 0.09

General Comments

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