INT87759

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Context Info
Confidence 0.68
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.88
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sepp1) growth (Sepp1) extracellular region (Sepp1)
Anatomy Link Frequency
brain 2
testis 1
barrel cortex 1
Sepp1 (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 14 97.56 Very High Very High Very High
anesthesia 16 96.60 Very High Very High Very High
Somatosensory cortex 1 96.04 Very High Very High Very High
melanocortin 1 receptor 33 74.24 Quite High
Hippocampus 22 73.00 Quite High
Eae 4 25.44 Quite Low
depression 3 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 14 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 4 79.84 Quite High
Death 9 75.00 Quite High
Skin Cancer 49 70.96 Quite High
Spasticity 1 67.76 Quite High
Anxiety Disorder 16 63.32 Quite High
Weight Loss 1 31.44 Quite Low
Weight Gain 1 25.00 Low Low
Cancer 9 6.96 Low Low
Metastasis 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Primary SEP are detected over the contralateral barrel cortex, but delayed signals appear over the motor cortex, secondary somatosensory cortex and the ipsilateral hemisphere.
Gene_expression (detected) of SEP in barrel cortex associated with somatosensory cortex
1) Confidence 0.68 Published 2000 Journal J. Neurosci. Methods Section Abstract Doc Link 10771075 Disease Relevance 0 Pain Relevance 0.14
Thus, it is likely that selenoprotein P deficiency has no deleterious developmental consequences, but reductions in selenium, whether through the disruption of selenoprotein P gene or dietary selenium restriction, results in discernable differences in synaptic function.
Gene_expression (deficiency) of selenoprotein P
2) Confidence 0.68 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1594565 Disease Relevance 0.18 Pain Relevance 0.19
Recently, however, targeted deletion of the selenoprotein P gene (Sepp) has been associated with a decrease in brain selenium concentration and with neurological dysfunction.
Gene_expression (deletion) of selenoprotein P gene in brain associated with anesthesia
3) Confidence 0.68 Published 2004 Journal J. Nutr. Section Abstract Doc Link 14704310 Disease Relevance 0.07 Pain Relevance 0.37
Deletion of Sepp1 results in sharp decreases of selenium levels in the brain and testis with dysfunction of those organs.
Gene_expression (Deletion) of Sepp1 in testis
4) Confidence 0.67 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17553992 Disease Relevance 0.23 Pain Relevance 0.07
By contrast, the Kit-dependent UVB response was characterized largely by genes involved in glycoprotein biosynthesis (C1galt1c1, Itm1, Man1a2, and Prkcsh) and the response to oxidative stress (Prdx5, Sepp1, and Stk25) and included functions and components relating to protease activity (Adcy7, Col6a1, Klk5, Hspb8, and Mbtps1) and the Golgi transport system (Inpp5e, Man1a2, Rer1, Ext1, Grb2, Inpp5e, Man1a2, Rer1, and Surf4).
Gene_expression (biosynthesis) of Sepp1 associated with stress
5) Confidence 0.49 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.17 Pain Relevance 0.07
Deletion of Sepp1 results in sharp decreases of selenium levels in the brain and testis with dysfunction of those organs.
Gene_expression (Deletion) of Sepp1 in brain
6) Confidence 0.23 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17553992 Disease Relevance 0.23 Pain Relevance 0.07

General Comments

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