INT87765

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Context Info
Confidence 0.07
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 2.59
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Acot1) mitochondrion (Acot1) lipid metabolic process (Acot1)
cytoplasm (Acot1)
Anatomy Link Frequency
neuronal 1
neurons 1
Acot1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 12 99.14 Very High Very High Very High
depression 4 97.28 Very High Very High Very High
Neurotransmitter 5 97.00 Very High Very High Very High
agonist 14 88.64 High High
Nicotine 2 86.24 High High
Analgesic 4 84.32 Quite High
Hippocampus 13 76.56 Quite High
Lasting pain 2 63.32 Quite High
Central nervous system 23 20.80 Low Low
Inflammation 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rabies Virus Infection 6 99.50 Very High Very High Very High
Anxiety Disorder 3 97.76 Very High Very High Very High
Depression 4 97.28 Very High Very High Very High
Akathisia 2 96.80 Very High Very High Very High
Disease 287 96.24 Very High Very High Very High
Hallucination 6 95.56 Very High Very High Very High
Proteostasis Deficiencies 3 85.64 High High
Prion Diseases 32 83.68 Quite High
Frailty 11 78.92 Quite High
Encephalitis 2 78.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although some competitive antagonists such as lophotoxin and alpha-bungarotoxin bind to the same high- and low-affinity sites as ACh, other cholinergic drugs may bind with opposite specificity.
ACh Binding (bind) of associated with antagonist
1) Confidence 0.07 Published 2000 Journal Neurochem. Int. Section Abstract Doc Link 10771117 Disease Relevance 0 Pain Relevance 0.35
Although some competitive antagonists such as lophotoxin and alpha-bungarotoxin bind to the same high- and low-affinity sites as ACh, other cholinergic drugs may bind with opposite specificity.
ACh Binding (bind) of associated with antagonist
2) Confidence 0.07 Published 2000 Journal Neurochem. Int. Section Abstract Doc Link 10771117 Disease Relevance 0 Pain Relevance 0.35
ACh can then bind to nicotinic and muscarinergic ACh receptors that are thus also targets for the treatment of AD [29-31].
ACh Binding (bind) of associated with disease
3) Confidence 0.01 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.55 Pain Relevance 0.15
This method involves complexing siRNA to a short peptide derived from the rabies virus glycoprotein that binds specifically to acetylcholine receptors (AchRs) on neuronal cells [27], [28].
AchRs Binding (binds) of in neuronal associated with rabies virus infection
4) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885418 Disease Relevance 0.56 Pain Relevance 0.06
Here we describe a new siRNA delivery system incorporating a small peptide that binds siRNA and acetylcholine receptors (AchRs), acting as a molecular messenger for delivery to neurons, and cationic liposomes that protect siRNA-peptide complexes from serum degradation.


AchRs Binding (binds) of in neurons
5) Confidence 0.00 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2885418 Disease Relevance 0.17 Pain Relevance 0
It is likely that AChEIs interact with atypical neuroleptics to synergistically increase the antipsychotic effect, this allowing a potential reduction in the dose of neuroleptics (Weiser et al 2002).
AChEIs Spec (likely) Binding (interact) of
6) Confidence 0.00 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654795 Disease Relevance 1.30 Pain Relevance 0.05

General Comments

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