INT87768

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Context Info
Confidence 0.26
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.18
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrnb1) transport (Chrnb1) plasma membrane (Chrnb1)
neurological system process (Chrnb1)
Anatomy Link Frequency
Molar 1
Chrnb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Antinociceptive 2 98.64 Very High Very High Very High
Analgesic 6 98.30 Very High Very High Very High
Nicotine 6 89.08 High High
agonist 11 87.88 High High
Action potential 11 84.08 Quite High
antagonist 5 82.96 Quite High
depression 4 55.72 Quite High
antinociception 2 33.20 Quite Low
Pain 2 25.00 Low Low
Calcium channel 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Poisoning 3 67.24 Quite High
Carcinoma 1 57.12 Quite High
Depression 4 55.72 Quite High
Increased Venous Pressure Under Development 5 45.72 Quite Low
Toxicity 1 41.84 Quite Low
Viral Infection 2 27.84 Quite Low
Viral Meningitis 2 27.20 Quite Low
Rabies Virus Infection 3 13.88 Low Low
Prion Diseases 16 5.00 Very Low Very Low Very Low
Infection 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study examines the hypothesis for the first time that the neonicotinoid insecticides and their imine metabolites and analogs display analgesic (antinociceptive) activity or adverse toxic effects associated with their action on binding to the alpha 4 beta 2 nicotinic acetylcholine receptor (AChR) subtype.
AChR Binding (binding) of associated with analgesic and antinociceptive
1) Confidence 0.26 Published 2001 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 11708903 Disease Relevance 0 Pain Relevance 0.50
The case of alpha-conotoxins (alpha-CoTxs) is unique since each alpha-CoTx from different species is recognized by a specific AChR type.
AChR Binding (recognized) of
2) Confidence 0.19 Published 2000 Journal Neurochem. Int. Section Abstract Doc Link 10771117 Disease Relevance 0 Pain Relevance 0.38
In summary, our observations of the ETA confirm earlier observations (de Paiva et al. 1999) that after an injection of BoNT/A, well formed axonal sprouts whose terminals are associated with AChR clusters are already present for several days before quantal release of ACh becomes readily detectable.
AChR Binding (associated) of
3) Confidence 0.11 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538785 Disease Relevance 0.12 Pain Relevance 0.07
Molar excesses of unlabeled RVG-9r, but not controlRVM-9r, successfully competed against fluorochrome-tagged RVG-9r for AchR binding in a time and dose dependent manner, confirming RVG-9r specificity (figure 2C).
AchR Binding (binding) of in Molar
4) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885418 Disease Relevance 0.06 Pain Relevance 0

General Comments

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