INT8777

Context Info Confidence 0.68 First Reported 1983 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 25 Total Number 25 Disease Relevance 7.77 Pain Relevance 3.18

nuclear envelope (Ache) extracellular space (Ache) extracellular region (Ache) cell adhesion (Ache) Golgi apparatus (Ache) plasma membrane (Ache)

Anatomy Link Frequency brain 4 cortex 4 hippocampus 3 blood 1 muscle 1 Ache (Mus musculus)

Pain Link Frequency Relevance Heat Analgesic 9 100.00 ischemia 2 99.68 Nerve growth factor 57 99.50 Enkephalin 7 99.50 Serotonin 9 99.28 narcan 9 98.98 Hippocampus 56 98.84 Action potential 3 96.52 monoamine 5 95.52 tetrodotoxin 6 93.08

Disease Link Frequency Relevance Heat Cough 3 100.00 Targeted Disruption 35 99.88 Stroke 21 99.88 Frontotemporal Dementia 131 99.84 Cv Unclassified Under Development 2 99.68 Disease 596 99.56 Aging 15 99.40 Amnesia 17 97.72 Attention Deficit Hyperactivity Disorder 11 96.32 Cognitive Disorder 303 92.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

After fusion of myoblasts into myotubes, there was a dramatic increase in the amount of both AChE and AChR.

Positive_regulation (increase) of AChE in myotubes

1) Confidence 0.68 Published 1983 Journal Exp. Cell Res. Section Abstract Doc Link 6617773 Disease Relevance 0 Pain Relevance 0.15

The acetylcholinesterase activity of whole brain was markedly elevated (P < 0.05) after phenytoin (12 mg kg?

Positive_regulation (elevated) of acetylcholinesterase in brain

2) Confidence 0.64 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1375237 Disease Relevance 0.82 Pain Relevance 0.04

In male mice immobilized during 30 min, statistically significant increase in adrenal acetylcholinesterase (Ache) activity--up to 154% of control value--has been observed.

Positive_regulation (increase) of Ache

3) Confidence 0.61 Published 1992 Journal Arch Int Physiol Biochim Biophys Section Abstract Doc Link 1379491 Disease Relevance 0.07 Pain Relevance 0.24

In male mice immobilized during 30 min, statistically significant increase in adrenal acetylcholinesterase (Ache) activity--up to 154% of control value--has been observed.

Positive_regulation (increase) of adrenal acetylcholinesterase

4) Confidence 0.61 Published 1992 Journal Arch Int Physiol Biochim Biophys Section Abstract Doc Link 1379491 Disease Relevance 0.07 Pain Relevance 0.23

Effect of the ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on the activities of AChE induced by scopolamine

Positive_regulation (induced) of AChE

5) Confidence 0.47 Published 2009 Journal J Nat Med Section Body Doc Link PMC2690856 Disease Relevance 0 Pain Relevance 0.06

In animals treated with scopolamine (1 mg/kg, i.p.), the AChE activity was significantly increased in comparison with the control group, and in animals pretreated with the ethanol extract of Magnolia officinalis (5 or 10 mg/kg) for 1 week and subsequently treated with scopolamine (1 mg/kg, i.p.), the AChE activity was significantly (P < 0.05) suppressed in both the hippocampus and cortex in a dose-dependent manner (Fig. 4a).

Positive_regulation (increased) of AChE in hippocampus associated with hippocampus

6) Confidence 0.47 Published 2009 Journal J Nat Med Section Body Doc Link PMC2690856 Disease Relevance 0 Pain Relevance 0.08

The ethanol extract of Magnolia officinalis and 4-O-methylhonokiol also dose-dependently attenuated the scopolamine-induced increase of acetylcholinesterase (AChE) activity in the cortex and hippocampus of mice, and inhibited AChE activity in vitro with IC50 (12 nM).

Positive_regulation (increase) of acetylcholinesterase in hippocampus associated with hippocampus

7) Confidence 0.47 Published 2009 Journal J Nat Med Section Abstract Doc Link PMC2690856 Disease Relevance 0.54 Pain Relevance 0.05

1 p.o.) significantly elevated brain AChE activity.

Positive_regulation (elevated) of AChE in brain

8) Confidence 0.46 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1375237 Disease Relevance 0.69 Pain Relevance 0.08

It appears that ranitidine exerts an inhibition of the "mixed" type on both AChE and BuChE, but the dissociation constants for BuChE were markedly higher than those for AChE.

Positive_regulation (exerts) of AChE

9) Confidence 0.46 Published 1984 Journal Biochem. Pharmacol. Section Abstract Doc Link 6329222 Disease Relevance 0 Pain Relevance 0.08

RESULTS: Abeta25-35 peptides induced the memory impairment and the increased levels of cortical and hippocampal AChE activity.

Positive_regulation (increased) of AChE

10) Confidence 0.46 Published 2010 Journal J Ethnopharmacol Section Body Doc Link 20435125 Disease Relevance 0.08 Pain Relevance 0

The consumption of TDE significantly improved the memory impairment and attenuated the brain levels of AChE activity induced by Abeta25-35 peptides.

Positive_regulation (induced) of AChE in brain

11) Confidence 0.46 Published 2010 Journal J Ethnopharmacol Section Body Doc Link 20435125 Disease Relevance 0.08 Pain Relevance 0

AIM OF STUDY: The present study aimed to determine the effect of TD on Abeta25-35 peptides induced cognitive deficits and acetylcholinesterase activity in mice.

Positive_regulation (induced) of acetylcholinesterase associated with analgesic and cough

12) Confidence 0.46 Published 2010 Journal J Ethnopharmacol Section Abstract Doc Link 20435125 Disease Relevance 0.25 Pain Relevance 0.10

After muscle innervation, there was an increase (amounting three-fold on E18) in the levels of hydrophilic vs. hydrophobic 16S AChE.

Positive_regulation (increase) of AChE in muscle

13) Confidence 0.44 Published 1991 Journal J. Neurosci. Res. Section Abstract Doc Link 1890703 Disease Relevance 0.09 Pain Relevance 0.09

Infusion of scopolamine (1 microM) caused a fivefold increase of ACh levels in wild-type animals but only a 50% increase in AChE-deficient mice.

Positive_regulation (increase) of AChE

14) Confidence 0.43 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 18023504 Disease Relevance 0 Pain Relevance 0.16

Naloxone pretreatment (10 mg/kg b.w., ip.) suppressed that increase, Ache activity remaining at the level of non-immobilized, saline treated mice.

Positive_regulation (increase) of Ache associated with narcan

15) Confidence 0.41 Published 1992 Journal Arch Int Physiol Biochim Biophys Section Abstract Doc Link 1379491 Disease Relevance 0.07 Pain Relevance 0.26

The ethanol extract of Magnolia officinalis and 4-O-methylhonokiol also dose-dependently attenuated the scopolamine-induced increase of acetylcholinesterase (AChE) activity in the cortex and hippocampus of mice, and inhibited AChE activity in vitro with IC50 (12 nM).

Positive_regulation (increase) of AChE in hippocampus associated with hippocampus

16) Confidence 0.41 Published 2009 Journal J Nat Med Section Abstract Doc Link PMC2690856 Disease Relevance 0.54 Pain Relevance 0.05

Besides, under CAE effect, the activity of acetylcholinesterase in the motor and especially in the visual cortex of the mice increased.

Positive_regulation (increased) of acetylcholinesterase in cortex associated with enkephalin

17) Confidence 0.38 Published 1985 Journal Zh Vyssh Nerv Deiat Im I P Pavlova Section Abstract Doc Link 2996249 Disease Relevance 0 Pain Relevance 0.58

After 14 days administration of donepezil, the cerebral acetylcholine level is increased by 35% and the AChE activity is decreased by 66% and 32% in rat brain and blood, respectively.

Positive_regulation (increased) of AChE in blood

18) Confidence 0.22 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654795 Disease Relevance 0 Pain Relevance 0.13

Similar to animal models of ischemia or stroke with elevated AQP4, AchE-S transgenic mice displayed lower baseline motion of water in CNS [52, 83] than their age-matched controls.

Positive_regulation (elevated) of AchE associated with targeted disruption, stroke and ischemia

19) Confidence 0.17 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.89 Pain Relevance 0.05

In animals treated with scopolamine (1 mg/kg, i.p.), the AChE activity was significantly increased in comparison with the control group, and in animals pretreated with the ethanol extract of Magnolia officinalis (5 or 10 mg/kg) for 1 week and subsequently treated with scopolamine (1 mg/kg, i.p.), the AChE activity was significantly (P < 0.05) suppressed in both the hippocampus and cortex in a dose-dependent manner (Fig. 4a).

Positive_regulation (increased) of AChE in cortex associated with hippocampus

20) Confidence 0.16 Published 2009 Journal J Nat Med Section Body Doc Link PMC2690856 Disease Relevance 0 Pain Relevance 0.08

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