INT87776

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Context Info
Confidence 0.62
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.71
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Gja1) Golgi apparatus (Gja1) transmembrane transport (Gja1)
cell-cell signaling (Gja1) cytoplasm (Gja1) signal transducer activity (Gja1)
Anatomy Link Frequency
Nerve 2
Gja1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 6 99.68 Very High Very High Very High
Dorsal horn 5 99.68 Very High Very High Very High
Sciatic nerve 3 96.48 Very High Very High Very High
qutenza 2 95.40 Very High Very High Very High
c fibre 2 94.88 High High
tetrodotoxin 1 89.44 High High
Peripheral nerve stimulation 2 87.60 High High
Spinal cord 4 80.88 Quite High
Enkephalin 1 78.32 Quite High
agonist 1 77.04 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 6 99.68 Very High Very High Very High
Dysmenorrhea 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After DADLE infusion, PKC-epsilon, but not PKC-delta, was coimmunoprecipitated with Cx43, and the level of phosphorylation of Cx43 at a PKC-dependent site (Ser(368)) was significantly elevated during ischemia.
Positive_regulation (elevated) of Phosphorylation (phosphorylation) of Cx43 associated with ischemia
1) Confidence 0.62 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17513490 Disease Relevance 0.50 Pain Relevance 0.57
Western blotting showed about a 4.5-fold increase in phosphorylation of GJA1 at S255, a MAPK1 site, after exposure to 100 microM 2,2'-DCB compared to untreated and solvent controls.
Positive_regulation (increase) of Phosphorylation (hosphorylation ) of GJA1
2) Confidence 0.49 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 16000550 Disease Relevance 0.21 Pain Relevance 0.26
Nerve stimulation increased the number of 13-8300-positive astrocytic gap junctions, as well as the levels of dephosphorylated connexin-43 in the dorsal horn on the stimulated side.
Positive_regulation (increased) of Phosphorylation (dephosphorylated) of connexin-43 in Nerve associated with dorsal horn
3) Confidence 0.47 Published 2000 Journal Neuroscience Section Abstract Doc Link 10771343 Disease Relevance 0 Pain Relevance 1.02

General Comments

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