INT87777

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Context Info
Confidence 0.62
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.76
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Gja1) Golgi apparatus (Gja1) transmembrane transport (Gja1)
cell-cell signaling (Gja1) cytoplasm (Gja1) signal transducer activity (Gja1)
Anatomy Link Frequency
hepatocytes 1
neural 1
Gja1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Peripheral nerve stimulation 2 96.08 Very High Very High Very High
Paracetamol 6 94.00 High High
Spinal cord 4 90.24 High High
Sciatic nerve 3 75.00 Quite High
Analgesic 1 69.32 Quite High
Dorsal horn 5 68.48 Quite High
tetrodotoxin 1 39.20 Quite Low
c fibre 2 28.00 Quite Low
qutenza 2 27.04 Quite Low
nociceptor 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 1 93.96 High High
Hepatotoxicity 4 93.60 High High
Apoptosis 4 91.68 High High
Disease Progression 1 89.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated whether connexin-43 at astrocytic gap junctions is similarly regulated in response to neural activation.
Spec (whether) Regulation (regulated) of connexin-43 in neural
1) Confidence 0.62 Published 2000 Journal Neuroscience Section Abstract Doc Link 10771343 Disease Relevance 0 Pain Relevance 0.27
In littermate wild-type rats, the injured centrilobular hepatocytes were positive for TUNEL staining and featured elevated expre ssion of cleaved caspase-3 and Cx43, which is not expressed in normal hepatocytes.
Regulation (positive) of Cx43 in hepatocytes
2) Confidence 0.19 Published 2010 Journal Toxicol Pathol Section Abstract Doc Link 20097795 Disease Relevance 0.76 Pain Relevance 0.54

General Comments

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