INT87779

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Context Info
Confidence 0.53
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.90
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Gja1) Golgi apparatus (Gja1) transmembrane transport (Gja1)
cell-cell signaling (Gja1) cytoplasm (Gja1) signal transducer activity (Gja1)
Anatomy Link Frequency
hepatocytes 1
Nerve 1
uterine 1
Gja1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 5 99.68 Very High Very High Very High
Sciatic nerve 3 96.48 Very High Very High Very High
qutenza 2 95.40 Very High Very High Very High
c fibre 2 94.88 High High
Paracetamol 6 94.00 High High
tetrodotoxin 1 89.44 High High
Peripheral nerve stimulation 2 87.60 High High
Dismenorea 1 84.04 Quite High
Action potential 29 83.04 Quite High
Spinal cord 4 80.88 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 4 93.60 High High
Apoptosis 4 91.68 High High
Targeted Disruption 2 91.36 High High
Disease Progression 1 86.60 High High
Dysmenorrhea 1 84.04 Quite High
Hypertrophy 6 67.28 Quite High
Obesity 3 50.00 Quite Low
Fibrosis 5 14.72 Low Low
Aging 11 5.00 Very Low Very Low Very Low
Heart Rate Under Development 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By day 21, the control animals had significant increases (P < or = 0.05) in mRNA for OT, FP, PGHS2, and Cx-43, a decrease (P < or = 0.05) in iNOS, and an increase (P < or = 0.05) in uterine sensitivity and responsiveness to OT.
Positive_regulation (increases) of Cx-43 in uterine
1) Confidence 0.53 Published 2005 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 15870103 Disease Relevance 0.08 Pain Relevance 0.22
Nerve stimulation increased the number of 13-8300-positive astrocytic gap junctions, as well as the levels of dephosphorylated connexin-43 in the dorsal horn on the stimulated side.
Positive_regulation (increased) of connexin-43 in Nerve associated with dorsal horn
2) Confidence 0.50 Published 2000 Journal Neuroscience Section Abstract Doc Link 10771343 Disease Relevance 0 Pain Relevance 1.02
In littermate wild-type rats, the injured centrilobular hepatocytes were positive for TUNEL staining and featured elevated expre ssion of cleaved caspase-3 and Cx43, which is not expressed in normal hepatocytes.
Positive_regulation (cleaved) of Cx43 in hepatocytes
3) Confidence 0.21 Published 2010 Journal Toxicol Pathol Section Abstract Doc Link 20097795 Disease Relevance 0.75 Pain Relevance 0.53
It follows, therefore, that there was an age-dependent increase of Nav1.5-negative/HCN4-positive/Cx43-negative tissue.
Positive_regulation (increase) of Cx43
4) Confidence 0.18 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.07 Pain Relevance 0.18

General Comments

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