INT87780

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Context Info
Confidence 0.77
First Reported 2000
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 22
Total Number 23
Disease Relevance 5.84
Pain Relevance 4.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Gja1) Golgi apparatus (Gja1) transmembrane transport (Gja1)
cell-cell signaling (Gja1) cytoplasm (Gja1) signal transducer activity (Gja1)
Anatomy Link Frequency
myocardium 2
uterine 2
bands 2
hepatocytes 1
brains 1
Gja1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 5 99.68 Very High Very High Very High
Acupuncture 15 99.44 Very High Very High Very High
Paracetamol 12 98.94 Very High Very High Very High
depression 4 98.00 Very High Very High Very High
Kinase C 10 96.96 Very High Very High Very High
fluoxetine 9 96.96 Very High Very High Very High
Sciatic nerve 3 96.48 Very High Very High Very High
Dismenorea 22 95.80 Very High Very High Very High
cytokine 11 95.00 High High
qutenza 2 92.12 High High
Disease Link Frequency Relevance Heat
Apoptosis 15 99.62 Very High Very High Very High
Hepatopulmonary Syndrome 1 99.56 Very High Very High Very High
Urological Neuroanatomy 4 99.48 Very High Very High Very High
Glioma 1 99.34 Very High Very High Very High
Hepatotoxicity 8 99.24 Very High Very High Very High
Cardiovascular Disorder Under Development 1 98.76 Very High Very High Very High
Depression 4 98.00 Very High Very High Very High
Overactive Bladder 4 97.92 Very High Very High Very High
Autism 4 97.60 Very High Very High Very High
Neuromyelitis Optica 31 96.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cx43 mRNA and protein expression were barely detectable by Northern or Western blots, respectively, in the detrusor layer of normal bladders, but bands were found with both techniques after 6 wk of obstruction.
Gene_expression (expression) of Cx43 mRNA in bands associated with overactive bladder
1) Confidence 0.77 Published 2003 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12676745 Disease Relevance 0.19 Pain Relevance 0
Chronic psychotropic drug treatment causes differential expression of connexin 43 and GFAP in frontal cortex of rats.
Gene_expression (expression) of connexin 43 in frontal cortex associated with urological neuroanatomy
2) Confidence 0.77 Published 2008 Journal Schizophr. Res. Section Title Doc Link 18585900 Disease Relevance 0.28 Pain Relevance 0.21
Using SDS-PAGE and western blotting technique, we observed that CX43 protein expression in prefrontal cortex was significantly increased following chronic treatment with fluoxetine and clozapine, while it was significantly decreased by haloperidol and lithium.
Gene_expression (expression) of CX43 in cortex associated with fluoxetine
3) Confidence 0.77 Published 2008 Journal Schizophr. Res. Section Abstract Doc Link 18585900 Disease Relevance 0.25 Pain Relevance 0.24
The current study investigated whether GFAP and CX43 expressions are affected by several commonly used psychotropic medications (clozapine, fluoxetine, haloperidol, lithium, olanzapine, and valproic acid).
Spec (whether) Gene_expression (expressions) of CX43 associated with fluoxetine
4) Confidence 0.77 Published 2008 Journal Schizophr. Res. Section Abstract Doc Link 18585900 Disease Relevance 0.27 Pain Relevance 0.22
OBJECTIVE: To observe the influence of silencing Connexin43 (Cx43) expression of partial acupoints on acupuncture effect, so as to probe into the mechanism of acupuncture treatment for primary dysmenorrhea.
Gene_expression (expression) of Connexin43 associated with dismenorea and acupuncture
5) Confidence 0.75 Published 2008 Journal Zhongguo Zhen Jiu Section Abstract Doc Link 18972735 Disease Relevance 0.10 Pain Relevance 0.23
OBJECTIVE: To observe the influence of silencing Connexin43 (Cx43) expression of partial acupoints on acupuncture effect, so as to probe into the mechanism of acupuncture treatment for primary dysmenorrhea.
Gene_expression (expression) of Cx43 associated with dismenorea and acupuncture
6) Confidence 0.75 Published 2008 Journal Zhongguo Zhen Jiu Section Abstract Doc Link 18972735 Disease Relevance 0.10 Pain Relevance 0.23
METHODS: The primary dysmenorrheal rat model made by oxytocin and RNA interference (RNAi) technology was used to silence the expression of Cx43 in acupoints.
Gene_expression (expression) of Cx43
7) Confidence 0.75 Published 2008 Journal Zhongguo Zhen Jiu Section Body Doc Link 18972735 Disease Relevance 0.09 Pain Relevance 0
CONCLUSION: Silencing Cx43 expression of partial acupoint can inhibit effectively the effect of acupuncture through decreasing OTR and VPR in endometrium of the dysmenorrheal rat and adjusting the prostaglandins (PGs) synthesis system, which possibly is one of the mechanisms of acupuncture for treatment of primary dysmenorrhea.


Gene_expression (expression) of Cx43 in endometrium
8) Confidence 0.75 Published 2008 Journal Zhongguo Zhen Jiu Section Body Doc Link 18972735 Disease Relevance 0 Pain Relevance 0
These results suggest that APAP hepatotoxicity involves apoptosis, and induction of Cx43 expression may play an important role in the apoptotic signaling.
Gene_expression (expression) of Cx43 associated with paracetamol, hepatotoxicity and apoptosis
9) Confidence 0.74 Published 2010 Journal Toxicol Pathol Section Abstract Doc Link 20097795 Disease Relevance 0.75 Pain Relevance 0.50
In littermate wild-type rats, the injured centrilobular hepatocytes were positive for TUNEL staining and featured elevated expre ssion of cleaved caspase-3 and Cx43, which is not expressed in normal hepatocytes.
Neg (not) Gene_expression (expressed) of Cx43 in hepatocytes
10) Confidence 0.74 Published 2010 Journal Toxicol Pathol Section Abstract Doc Link 20097795 Disease Relevance 0.75 Pain Relevance 0.53
Cx43 mRNA and protein expression were barely detectable by Northern or Western blots, respectively, in the detrusor layer of normal bladders, but bands were found with both techniques after 6 wk of obstruction.
Gene_expression (detectable) of Cx43 mRNA in bands associated with overactive bladder
11) Confidence 0.67 Published 2003 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12676745 Disease Relevance 0.19 Pain Relevance 0
Nerve stimulation increased the number of 13-8300-positive astrocytic gap junctions, as well as the levels of dephosphorylated connexin-43 in the dorsal horn on the stimulated side.
Gene_expression (levels) of connexin-43 in Nerve associated with dorsal horn
12) Confidence 0.60 Published 2000 Journal Neuroscience Section Abstract Doc Link 10771343 Disease Relevance 0 Pain Relevance 1.00
Astrocytic markers glial fibrillary acidic protein (GFAP) and connexin 43 (CX43) are known to have altered expression in brains of subjects with psychiatric disorders including autism and major depression.
Gene_expression (expression) of CX43 in brains associated with autism and depression
13) Confidence 0.60 Published 2008 Journal Schizophr. Res. Section Abstract Doc Link 18585900 Disease Relevance 0.27 Pain Relevance 0.19
RESULTS: (1) The times of writhing body (9.43 +/- 3.87 and 10.28 +/- 4.23) were significantly lower and the latency period of writhing body (12.43 +/- 3.46, 11.00 +/- 3.65) were longer in the group A and the group A+IC as compared with (15.43 +/- 5.13, 17.00 +/- 3.87) and (7.57 +/- 1.99, 8.43 +/- 2.57) in the group M and group A+I (P < 0.05), respectively. (2) The levels of Cx43 mR NA level and protein expression of acupoint in the group A+I were significantly lower than those of the group N (P < 0.05). (3) OTR and VPR mRNA in the uterus in the group A and the group A+IC were significantly lower than those in the group M and the group A+I (P < 0.05), with no significant difference between the group M and the group A+I (P > 0.05). (4) As compared with the group M, PGE2 level increased and PGF2alpha level decreased in the group A and the group A+IC (P < 0.05).
Gene_expression (expression) of Cx43 in PGE2
14) Confidence 0.58 Published 2008 Journal Zhongguo Zhen Jiu Section Body Doc Link 18972735 Disease Relevance 0.06 Pain Relevance 0
Before parturition, the uterus undergoes a process of activation, during which there are significant changes in expression of genes associated with increased uterine contractility, including the receptors for oxytocin (OT) and prostaglandin (PG)F(2alpha) (FP), PGH(2) synthase isoform 2 (PGHS2), the gap junction protein connexin-43 (Cx-43), and the inducible isoform of nitric oxide synthase (iNOS).
Gene_expression (expression) of Cx-43 in uterine
15) Confidence 0.46 Published 2005 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 15870103 Disease Relevance 0.09 Pain Relevance 0.17
Before parturition, the uterus undergoes a process of activation, during which there are significant changes in expression of genes associated with increased uterine contractility, including the receptors for oxytocin (OT) and prostaglandin (PG)F(2alpha) (FP), PGH(2) synthase isoform 2 (PGHS2), the gap junction protein connexin-43 (Cx-43), and the inducible isoform of nitric oxide synthase (iNOS).
Gene_expression (expression) of gap junction protein connexin-43 in uterine
16) Confidence 0.46 Published 2005 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 15870103 Disease Relevance 0.09 Pain Relevance 0.17
There are multiple factors implicated in vascular abnormalities under diabetic conditions.31 The matrix in the diabetic vascular wall is altered due to changes in MMP2 and MMP9 expression resulting in an increase in accumulated fibroid substances, which may participate in adversely affecting vascular activity.12,16 The intercellular gap junction connexin proteins are important for maintaining normal vascular tone through passing small molecules between cells, among which Cx40 (connexin 40) is active in the vascular wall and its downregulation results in a compromised pulmonary vascular dilatation.12 Drug intervention normalizes the abnormal Cx43, leading to a recovery of the cardiovascular abnormalities.22 An activated PKC?
Gene_expression (normalizes) of Cx43 associated with kinase c, uterine fibroids, diabetes mellitus, congenital anomalies, hepatopulmonary syndrome and cardiovascular disorder under development
17) Confidence 0.27 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 1.15 Pain Relevance 0.09
In the guinea pig, we have previously shown an age-dependent increase in SAN tissue lacking expression of Cx43 and Cav1.2 (major L-type Ca2+ channel isoform in working myocardium) [27,28].
Neg (lacking) Gene_expression (expression) of Cx43 in myocardium
18) Confidence 0.20 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.08 Pain Relevance 0.16
The main constituent protein for the cardiac gap junctions, Connexin-43, was also detected in the x-gal labeled cells at 6 weeks specimens only in the coronary ligation groups (Fig. 1E and Fig. 1F).



Gene_expression (detected) of Connexin-43
19) Confidence 0.17 Published 2007 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2570564 Disease Relevance 0.20 Pain Relevance 0
In the present study, in both young and old animals, the tissue that lacked expression of Nav1.5 expressed HCN4 (Figs. 3 and 4), but not Cx43 (data not shown)—Cx43 is a gap junction channel known to be present in the working myocardium, but absent from the SAN.
Neg (not) Gene_expression (expressed) of Cx43 in myocardium
20) Confidence 0.14 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0 Pain Relevance 0.20

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