INT87785

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Context Info
Confidence 0.39
First Reported 2000
Last Reported 2001
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.85
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pnoc)
Anatomy Link Frequency
spinal cord 2
Pnoc (Mus musculus)
Pain Link Frequency Relevance Heat
orphanin 14 100.00 Very High Very High Very High
Spinal cord 1 99.74 Very High Very High Very High
substance P 4 99.36 Very High Very High Very High
nMDA receptor 4 96.52 Very High Very High Very High
allodynia 5 95.44 Very High Very High Very High
Hyperalgesia 5 94.88 High High
qutenza 4 92.84 High High
Pain 5 91.64 High High
antagonist 1 88.72 High High
intrathecal 1 79.48 Quite High
Disease Link Frequency Relevance Heat
Stress 6 98.36 Very High Very High Very High
Neuropathic Pain 6 95.44 Very High Very High Very High
Hyperalgesia 6 94.88 High High
Pain 2 91.64 High High
Hypoxia 1 82.68 Quite High
Nociception 1 77.56 Quite High
Targeted Disruption 2 75.00 Quite High
Neurodegenerative Disease 1 60.96 Quite High
Brain Injury 1 59.68 Quite High
Stroke 1 58.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whereas this treatment markedly reduced the content of substance P in the spinal cord, it did not affect the nociceptin content or the expression of nociceptin receptors and GluRvarepsilon and GluRzeta subunits of N-methyl-D-aspartate receptors in it.
Neg (not) Regulation (affect) of Regulation (content) of nociceptin in spinal cord associated with nmda receptor, orphanin, spinal cord and substance p
1) Confidence 0.39 Published 2000 Journal Neuroscience Section Abstract Doc Link 10771345 Disease Relevance 1.25 Pain Relevance 2.27
Blockade of the p38 or the ERK MAP kinase pathways (by SB202190 and PD98059, respectively) prevented the H2O2-induced increase in pENK and pOFQ mRNA levels indicating a central role for these cascades in the regulation of pOFQ and pENK genes in response to oxidative stress.
Regulation (role) of Regulation (regulation) of pOFQ associated with stress
2) Confidence 0.08 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11595755 Disease Relevance 0.60 Pain Relevance 0.17

General Comments

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