INT87786

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Context Info
Confidence 0.61
First Reported 2000
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 3.06
Pain Relevance 5.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pnoc)
Anatomy Link Frequency
spinal cord 4
sensory neurons 2
Pnoc (Mus musculus)
Pain Link Frequency Relevance Heat
orphanin 29 100.00 Very High Very High Very High
Spinal cord 2 99.74 Very High Very High Very High
Pain 14 99.42 Very High Very High Very High
Inflammation 4 99.42 Very High Very High Very High
substance P 8 99.36 Very High Very High Very High
nMDA receptor 8 97.80 Very High Very High Very High
Opioid 1 97.68 Very High Very High Very High
allodynia 10 95.44 Very High Very High Very High
Hyperalgesia 10 94.88 High High
qutenza 8 92.84 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 12 95.44 Very High Very High Very High
Hyperalgesia 12 94.88 High High
INFLAMMATION 1 93.64 High High
Pain 5 92.16 High High
Ganglion Cysts 3 85.48 High High
Nociception 2 77.56 Quite High
Targeted Disruption 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whereas this treatment markedly reduced the content of substance P in the spinal cord, it did not affect the nociceptin content or the expression of nociceptin receptors and GluRvarepsilon and GluRzeta subunits of N-methyl-D-aspartate receptors in it.
Neg (not) Regulation (affect) of Gene_expression (expression) of nociceptin in spinal cord associated with nmda receptor, orphanin, spinal cord and substance p
1) Confidence 0.61 Published 2000 Journal Neuroscience Section Abstract Doc Link 10771345 Disease Relevance 1.32 Pain Relevance 2.36
Whereas this treatment markedly reduced the content of substance P in the spinal cord, it did not affect the nociceptin content or the expression of nociceptin receptors and GluRvarepsilon and GluRzeta subunits of N-methyl-D-aspartate receptors in it.
Regulation (content) of Gene_expression (expression) of nociceptin in spinal cord associated with nmda receptor, orphanin, spinal cord and substance p
2) Confidence 0.45 Published 2000 Journal Neuroscience Section Abstract Doc Link 10771345 Disease Relevance 1.31 Pain Relevance 2.35
Bacterial lipopolysaccharide regulates nociceptin expression in sensory neurons.
Regulation (regulates) of Gene_expression (expression) of nociceptin in sensory neurons associated with inflammation and orphanin
3) Confidence 0.16 Published 2008 Journal J. Neurosci. Res. Section Title Doc Link 18027846 Disease Relevance 0.42 Pain Relevance 0.95

General Comments

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