INT878

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Context Info
Confidence 0.43
First Reported 1978
Last Reported 2009
Negated 8
Speculated 2
Reported most in Abstract
Documents 13
Total Number 16
Disease Relevance 1.13
Pain Relevance 6.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh1) signal transduction (Gh1) mitochondrion (Gh1)
extracellular space (Gh1) extracellular region (Gh1) plasma membrane (Gh1)
Anatomy Link Frequency
pituitary 4
plasma 2
PVN 2
neurons 2
gonadotrophs 2
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 43 100.00 Very High Very High Very High
Morphine 21 100.00 Very High Very High Very High
methadone 18 100.00 Very High Very High Very High
narcan 18 100.00 Very High Very High Very High
Opioid 11 100.00 Very High Very High Very High
opiate 4 100.00 Very High Very High Very High
rapifen 5 99.90 Very High Very High Very High
Versed 5 99.90 Very High Very High Very High
tetrodotoxin 2 99.00 Very High Very High Very High
anesthesia 3 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 74 100.00 Very High Very High Very High
Fetal Weight 2 90.80 High High
Hematoma 2 90.56 High High
Stupor 1 87.84 High High
Disease 6 84.80 Quite High
Impaired Glucose Tolerance 2 77.60 Quite High
Acromegaly 52 76.60 Quite High
Urological Neuroanatomy 1 61.04 Quite High
Frailty 1 41.76 Quite Low
Diarrhoea 4 16.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Direct injection of clonidine (0.1 microgram/microliters) into the PVN significantly stimulated GH secretion, whereas injection of isoproterenol (2.5 micrograms/microliters) into the PVN did not affect GH levels when compared to controls.
Neg (not) Regulation (affect) of Gene_expression (levels) of GH in PVN associated with clonidine
1) Confidence 0.43 Published 1992 Journal Neurochem. Res. Section Abstract Doc Link 1361032 Disease Relevance 0.06 Pain Relevance 0.51
The present results indicate that the inhibitory activity of brain HA on GH release consequent to activation of central alpha 2-receptors does not involve a modulatory action on catecholaminergic or somatostatinergic neurons but probably other mechanisms like the modulation of neurons synthetizing GH-releasing hormone.
Regulation (modulation) of Gene_expression (synthetizing) of GH in neurons
2) Confidence 0.35 Published 1993 Journal Neuroendocrinology Section Abstract Doc Link 7901783 Disease Relevance 0 Pain Relevance 0.59
By week 24/early termination, IGF-1 levels were controlled in 93.7% of switch and 46.2% of “other” patients, while GH levels were controlled in 76.9% and 39.1% of patients, respectively.
Regulation (controlled) of Gene_expression (levels) of GH
3) Confidence 0.33 Published 2009 Journal Pituitary Section Abstract Doc Link PMC2855862 Disease Relevance 0.19 Pain Relevance 0.07
Although the reason for the observed difference in discordant IGF-1 and GH levels noted in the current versus previous studies is not clear, one possible explanation may be the use of a single SSA in the current study.
Regulation (difference) of Gene_expression (levels) of GH
4) Confidence 0.33 Published 2009 Journal Pituitary Section Body Doc Link PMC2855862 Disease Relevance 0.34 Pain Relevance 0.04
On the other hand, pretreatment with anti-TRH did not affect the basal serum GH levels nor the anti-SS-induced GH release.
Neg (nor) Regulation (affect) of Gene_expression (levels) of GH
5) Confidence 0.29 Published 1978 Journal Endocrinology Section Abstract Doc Link 107024 Disease Relevance 0 Pain Relevance 0.07
Tetrodotoxin, a voltage-sensitive Na+ channel blocker, had no effect on either hGRF- or excess K+-induced GH secretion. cAMP production by hGRF was not greatly affected by replacing extracellular Na+.
Neg (no) Regulation (effect) of Gene_expression (production) of GH associated with tetrodotoxin
6) Confidence 0.24 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 2833113 Disease Relevance 0 Pain Relevance 0.14
Tetrodotoxin, a voltage-sensitive Na+ channel blocker, had no effect on either hGRF- or excess K+-induced GH secretion. cAMP production by hGRF was not greatly affected by replacing extracellular Na+.
Neg (not) Regulation (affected) of Gene_expression (production) of GH associated with tetrodotoxin
7) Confidence 0.24 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 2833113 Disease Relevance 0 Pain Relevance 0.14
In order to investigate the role of opioids in the regulation of PRL and GH gene expression in the rat pituitary, we studied the effects of chronic administration of the opioid drug morphine and an opiate receptor antagonist naloxone on both PRL and GH gene expression as measured by in situ hybridization.
Spec (investigate) Regulation (regulation) of Gene_expression (expression) of GH in pituitary associated with antagonist, narcan, opiate, opioid and morphine
8) Confidence 0.23 Published 1993 Journal J. Neuroendocrinol. Section Abstract Doc Link 8680424 Disease Relevance 0 Pain Relevance 0.96
In order to investigate the role of opioids in the regulation of PRL and GH gene expression in the rat pituitary, we studied the effects of chronic administration of the opioid drug morphine and an opiate receptor antagonist naloxone on both PRL and GH gene expression as measured by in situ hybridization.
Regulation (effects) of Gene_expression (expression) of GH in pituitary associated with antagonist, narcan, opiate, opioid and morphine
9) Confidence 0.23 Published 1993 Journal J. Neuroendocrinol. Section Abstract Doc Link 8680424 Disease Relevance 0 Pain Relevance 1.15
N-Nitro-L-arginine methyl ester (25 mg/kg i.p.) decreased cold-stimulated (rats were kept 30 min at +4 degrees C) TSH levels but did not alter basal TSH, GH or prolactin levels.
Neg (not) Regulation (alter) of Gene_expression (levels) of GH
10) Confidence 0.22 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7957594 Disease Relevance 0 Pain Relevance 0.72
In contrast, elevated levels of GH in ambulatory animals inhibit the positive affect of IGF-I, indicating that in fact elevated GH in ambulatory animals may not be permissive to elevated IGF-I function, but that improved healing from IGF-I addition is not dependent on exogenously elevated GH levels.
Neg (not) Regulation (dependent) of Gene_expression (levels) of GH
11) Confidence 0.21 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1851714 Disease Relevance 0.09 Pain Relevance 0.03
Basal PRL, GH and LH levels and LH, PRL and GH responses to acute METH challenge were not affected by the CD regimen.
Neg (not) Regulation (affected) of Gene_expression (levels) of GH associated with methadone
12) Confidence 0.20 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 4040169 Disease Relevance 0 Pain Relevance 0.99
Basal PRL, GH and LH levels and LH, PRL and GH responses to acute METH challenge were not affected by the CD regimen.
Neg (not) Regulation (affected) of Gene_expression (levels) of GH associated with methadone
13) Confidence 0.20 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 4040169 Disease Relevance 0 Pain Relevance 0.99
In this study, we investigated the effects of exercise during pregnancy on maternal plasma levels of GH, IGF-I and IGFBP-3 and on fetal development.
Spec (investigated) Regulation (effects) of Gene_expression (levels) of GH in plasma
14) Confidence 0.17 Published 2006 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 16340176 Disease Relevance 0.09 Pain Relevance 0.06
The next natural question was: do gonadotrophs also affect the function of PRL, GH and FS cells?
Regulation (affect) of Gene_expression (function) of GH in gonadotrophs
15) Confidence 0.05 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0
[The behavior of the stress hormones cortisol, somatotropin (STH) and prolactin during anesthesia induction with midazolam-alfentanil in comparison with thiopental].
Regulation (behavior) of Gene_expression (cortisol) of somatotropin associated with stress, rapifen, anesthesia and versed
16) Confidence 0.05 Published 1993 Journal Anaesthesiol Reanim Section Title Doc Link 8397670 Disease Relevance 0.36 Pain Relevance 0.51

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