INT87819

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Context Info
Confidence 0.81
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 7.69
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CD34) cell proliferation (CD34) signal transduction (CD34)
extracellular region (CD34) cell adhesion (CD34) cell motility (CD34)
Anatomy Link Frequency
blood 3
liver 2
Stem 2
endothelial cell 1
CFU-GM 1
CD34 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 18 96.16 Very High Very High Very High
cytokine 50 91.68 High High
abdominal pain 3 80.44 Quite High
isoflurane 10 72.64 Quite High
anesthesia 4 68.48 Quite High
Pain 14 67.72 Quite High
dexamethasone 3 66.32 Quite High
Central nervous system 9 61.56 Quite High
alcohol 6 46.24 Quite Low
Inflammatory mediators 3 24.88 Low Low
Disease Link Frequency Relevance Heat
Age-related Macular Degeneration 3 99.66 Very High Very High Very High
Disease 79 99.56 Very High Very High Very High
Stress 3 98.80 Very High Very High Very High
Stroke 41 98.08 Very High Very High Very High
Myocardial Infarction 52 98.04 Very High Very High Very High
Coronary Artery Disease 60 97.76 Very High Very High Very High
Cirrhosis 48 97.20 Very High Very High Very High
Acute Liver Failure 4 97.08 Very High Very High Very High
Liver Cancer 8 96.92 Very High Very High Very High
Metastasis 8 96.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The efficacy and safety of high-dose lenograstim on CD34 positive (CD34+) cell mobilization into peripheral blood were investigated in 18 healthy male volunteers.
Localization (mobilization) of CD34 in blood
1) Confidence 0.81 Published 2000 Journal Rinsho Ketsueki Section Abstract Doc Link 10774248 Disease Relevance 0 Pain Relevance 0
The antigens tested by immunohistochemistry were: pan-keratin, keratin Cam 5.2, cytokeratin 7, cytokeratin 10, cytokeratin 18, cytokeratin 20, epithelial membrane antigen, vimentin, desmin, actin, myosin, CD34, CD68, CD99, CD117, S-100 protein, and bcl-2.
Localization (desmin) of CD34
2) Confidence 0.73 Published 2007 Journal Virchows Arch Section Body Doc Link PMC2039817 Disease Relevance 0.44 Pain Relevance 0
The mouse MSC populations were analyzed for the following surface antigens for phenotypic characterization: CD29 (>90%), CD44 (>80%) and CD105 (>80%) and were free of hematopoietic cell phenotype CD11b (<1%), CD34 (<1%), and CD45 (<1%).
Localization (free) of CD34 in hematopoietic cell
3) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.35 Pain Relevance 0.06
Moreover, gating strategies to separate the CD34+ HSC from irrelevant cell populations, as well as inclusion of CD34dim and CD34bright populations were established.
Localization (separate) of CD34
4) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2972200 Disease Relevance 0 Pain Relevance 0
An inverse correlation of CD45dimCD34+KDR+ with disease activity (r?
Localization (correlation) of CD45dimCD34 associated with disease
5) Confidence 0.71 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2972200 Disease Relevance 0.90 Pain Relevance 0
The efficacy and safety of high-dose lenograstim on CD34 positive (CD34+) cell mobilization into peripheral blood were investigated in 18 healthy male volunteers.
Localization (mobilization) of CD34 in blood
6) Confidence 0.70 Published 2000 Journal Rinsho Ketsueki Section Abstract Doc Link 10774248 Disease Relevance 0 Pain Relevance 0
Human hematopoietic stem/progenitor-enriched CD34(+) cells are mobilized into peripheral blood during stress related to ischemic stroke or acute myocardial infarction.
Localization (mobilized) of CD34 in blood associated with stress, stroke and myocardial infarction
7) Confidence 0.68 Published 2005 Journal Eur. J. Haematol. Section Title Doc Link 16313257 Disease Relevance 0.61 Pain Relevance 0.07
The recently approved drug AMD-3100 stimulates CD34 and CFU-GM mobilization approximately half of values obtained for G-CSF alone, however has been demonstrated to synergize with G-CSF [67].
Localization (mobilization) of CD34 in CFU-GM associated with age-related macular degeneration
8) Confidence 0.65 Published 2010 Journal J Transl Med Section Body Doc Link PMC2862021 Disease Relevance 0.48 Pain Relevance 0
As with other mobilizing agents, Stem-Kine peripheralization of CD34 and CD133 cells started to drop on day 14 of administration.
Localization (peripheralization) of CD34 in Stem
9) Confidence 0.61 Published 2010 Journal J Transl Med Section Body Doc Link PMC2862021 Disease Relevance 0.48 Pain Relevance 0
Stem-Kine mobilizes CD34 and CD133 Cells
Localization (mobilizes) of CD34 in Stem
10) Confidence 0.61 Published 2010 Journal J Transl Med Section Body Doc Link PMC2862021 Disease Relevance 0 Pain Relevance 0
It is possible to separate graft cells into CD34+ and CD34?
Localization (separate) of CD34
11) Confidence 0.60 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896720 Disease Relevance 0.58 Pain Relevance 0
It is possible to separate graft cells into CD34+ and CD34?
Localization (separate) of CD34
12) Confidence 0.60 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896720 Disease Relevance 0.52 Pain Relevance 0
In 1997, eEPCs were the first putative endothelial progenitors isolated in vitro by culturing CD34+ VEGFR2+ mononuclear blood cells on fibronectin [25] and confirming a subsequent increase in expression of endothelial cell-associated markers such as CD34, CD31, VEGFR2, Tie2, and E-selectin.
Localization (blood cells) of CD34 in endothelial cell
13) Confidence 0.56 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2881111 Disease Relevance 0.18 Pain Relevance 0.05
Co-transplantation of CD34+ HSCs and CD34?
Localization (transplantation) of CD34
14) Confidence 0.55 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2597748 Disease Relevance 0 Pain Relevance 0
A total of four groups were created: 1) MSC transplantation alone, 2) VEGF-adsorbed MSC transplantation, 3) co-transplantation of MSCs and CD34+ cells, and 4) VEGF-adsorbed co-transplantation of MSCs and CD34+ cells.
Localization (transplantation) of CD34
15) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597748 Disease Relevance 0 Pain Relevance 0.22
Co-transplantation of CD34+ HSCs and CD34?
Localization (transplantation) of CD34
16) Confidence 0.55 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2597748 Disease Relevance 0 Pain Relevance 0
The most important immunohistochemical markers of GISTs are expression of KIT (CD117), which is found in over 90 percent of GISTs, and CD34 which occurs in over 80 percent [11].
Localization (found) of CD34
17) Confidence 0.46 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2965163 Disease Relevance 0.85 Pain Relevance 0.08
Yannaki et al. described boost infusions of mobilized CD34+ cells after a standard G-CSF regimen in two patients.
Localization (mobilized) of CD34
18) Confidence 0.43 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2963137 Disease Relevance 0.65 Pain Relevance 0
A significant biochemical and histopathological improvement was achieved by intraportal administration of mobilized CD34+ BMSCs following G-CSF exposure in one patient affected by drug-induced acute liver failure [91].
Localization (mobilized) of CD34 in liver associated with acute liver failure
19) Confidence 0.43 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2963137 Disease Relevance 0.65 Pain Relevance 0
A spontaneous mobilization of CD34+ cells has been reported following liver resection in patients with primary liver cancer or metastasis [81].
Localization (mobilization) of CD34 in liver associated with liver cancer and metastasis
20) Confidence 0.40 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2963137 Disease Relevance 0.54 Pain Relevance 0

General Comments

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