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Context Info
Confidence 0.28
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.63
Pain Relevance 2.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Gpi) carbohydrate metabolic process (Gpi) cytoplasm (Gpi)
cytosol (Gpi) extracellular space (Gpi) extracellular region (Gpi)
Anatomy Link Frequency
neurons 2
subthalamic nucleus 1
striatum 1
Gpi (Rattus norvegicus)
Pain Link Frequency Relevance Heat
withdrawal 33 100.00 Very High Very High Very High
Morphine 25 100.00 Very High Very High Very High
Dopamine 138 99.84 Very High Very High Very High
agonist 65 99.40 Very High Very High Very High
Locus ceruleus 16 99.28 Very High Very High Very High
midbrain 7 98.32 Very High Very High Very High
Pain 2 98.06 Very High Very High Very High
Opioid 24 97.60 Very High Very High Very High
Cannabinoid 15 94.32 High High
antagonist 19 93.84 High High
Disease Link Frequency Relevance Heat
Pain 2 98.06 Very High Very High Very High
Opiate Addiction 12 97.82 Very High Very High Very High
Nociception 2 96.32 Very High Very High Very High
Catalepsy 1 94.56 High High
Disease 48 94.04 High High
Sleep Disorders 26 92.88 High High
Movement Disorders 4 87.60 High High
Parkinson's Disease 28 68.96 Quite High
Syndrome 3 67.00 Quite High
Dyskinesias 1 58.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The caudal intralaminar nuclei, in particular the Centrum-Medianum Parafascicularis (CM-Pf) nucleus complex, are involved in various functions, particularly in pain processing and in motor control, through their projections to the subthalamic nucleus and their afferents from the pallidum internus (GPi) (or entopeduncular nucleus in the rat).
Regulation (afferents) of GPi in subthalamic nucleus associated with pain
1) Confidence 0.28 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 18812212 Disease Relevance 0.40 Pain Relevance 0.14
GPi activity is indirectly under the control of dopamine released in the striatum, via the direct and indirect pathways.
Regulation (control) of GPi in striatum associated with dopamine
2) Confidence 0.16 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0.18 Pain Relevance 0.31
Overall, 57% and 56% of the LC-projecting neurons in PGi and PrH, respectively, were also immunoreactive for ENK, suggesting that enkephalinergic neurons of PGi and PrH are major afferents to noradrenergic LC neurons.
Regulation (afferents) of PGi in neurons associated with locus ceruleus
3) Confidence 0.15 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1379635 Disease Relevance 0 Pain Relevance 0.52
The major source of dopamine in the BG is the midbrain dopaminergic neurons, particularly the SNc (A9 group), and these neurons primarily target the striatum, GPe and GPi.
Regulation (target) of GPi in neurons associated with dopamine and midbrain
4) Confidence 0.06 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2996256 Disease Relevance 0.69 Pain Relevance 0.44
Given the relationship between CB1Rs/Opioid Withdrawal/Ach system, in the present paper we have designed new CB1Rs agonists named A-F [30, 31] and evaluated their role in mediating morphine withdrawal in GPI.
Regulation (role) of GPI associated with agonist, withdrawal, opioid and morphine
5) Confidence 0.04 Published 2009 Journal The Open Biochemistry Journal Section Body Doc Link PMC2811858 Disease Relevance 0.36 Pain Relevance 1.09

General Comments

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