INT87822

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Context Info
Confidence 0.47
First Reported 2000
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 0.84
Pain Relevance 2.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp1a2) endoplasmic reticulum (Cyp1a2) enzyme binding (Cyp1a2)
response to stress (Cyp1a2)
Cyp1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Duloxetine 94 100.00 Very High Very High Very High
lidocaine 13 99.92 Very High Very High Very High
fluoxetine 13 99.12 Very High Very High Very High
tricyclic antidepressant 3 96.78 Very High Very High Very High
Endep 9 87.84 High High
monoamine 2 82.40 Quite High
sSRI 12 81.72 Quite High
Potency 3 77.60 Quite High
antidepressant 3 75.00 Quite High
Bioavailability 30 74.92 Quite High
Disease Link Frequency Relevance Heat
Body Weight 2 81.92 Quite High
Anxiety Disorder 4 77.52 Quite High
Hepatic Insufficiency 2 76.88 Quite High
Fungal Infection 1 74.12 Quite High
Syndrome 3 73.52 Quite High
Fibromyalgia 100 64.44 Quite High
Adverse Drug Reaction 2 64.04 Quite High
Hepatotoxicity 1 62.40 Quite High
Injury 1 61.28 Quite High
Allergic Dermatitis 1 57.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to the tested tricyclic antidepressants, fluoxetine did not exert any considerable effect on the 3-N- or 1-N-demethylation of caffeine (Ki = 152 and 196 microM, respectively), which indicates its low affinity for CYP1A2.
CYP1A2 Binding (affinity) of associated with tricyclic antidepressant and fluoxetine
1) Confidence 0.47 Published 2001 Journal Pol J Pharmacol Section Abstract Doc Link 11990081 Disease Relevance 0 Pain Relevance 0.83
Using phenacetin and chlorzoxazone as probe drugs, the activities of CYP1A2 and CYP2E1 were monitored in vivo.
CYP1A2 Binding (activities) of
2) Confidence 0.34 Published 2010 Journal J Asian Nat Prod Res Section Abstract Doc Link 20496194 Disease Relevance 0.08 Pain Relevance 0.07
Pharmacokinetic studies looked at the interaction between duloxetine and fluvoxamine, a known potent inhibitor of CYP1A2.
CYP1A2 Binding (interaction) of associated with duloxetine
3) Confidence 0.30 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350145 Disease Relevance 0.07 Pain Relevance 0.54
Lidocaine is metabolized by cytochrome P450 3A4 (CYP3A4) and CYP1A2 enzymes, but inhibitors of CYP3A4 have had only a minor effect on its pharmacokinetics.
CYP1A2 Binding (metabolized) of associated with lidocaine
4) Confidence 0.18 Published 2006 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 16918719 Disease Relevance 0 Pain Relevance 0.37
There is evidence for females having lower activity of CYP1A2, CYP2E1, and UGT; higher activity of CYP3A4, CYP2A6, and CYP2B6; and no differences in CPY2C9 and CYP2D6 activity.
CYP1A2 Neg (no) Binding (activity) of
5) Confidence 0.07 Published 2008 Journal Int. Rev. Neurobiol. Section Abstract Doc Link 18929073 Disease Relevance 0.42 Pain Relevance 0.06
Fluvoxamine is metabolized to inactive metabolites by CYP1A2 and CYP2D6.
CYP1A2 Binding (metabolized) of
6) Confidence 0.07 Published 2000 Journal Ther Drug Monit Section Abstract Doc Link 10774624 Disease Relevance 0 Pain Relevance 0.61
The interaction between milnacipran and the cytochrome P450 (CYP) isoenzymes is limited, with no interaction with CYP2D6 or CYP2C19 pathways and minimal interaction with CYP1A2, CYP2C19, CYP2D6 and CYP3A4.
CYP1A2 Neg (no) Binding (interaction) of
7) Confidence 0.05 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004654 Disease Relevance 0.27 Pain Relevance 0.21
Food-drug interactions involving CYP1A2, CYP2E1, glucuronosyltransferases and glutathione S-transferases have also been documented, although most of these interactions are modest in magnitude and clinically relevant only for drugs that have a narrow therapeutic range.
CYP1A2 Binding (interactions) of
8) Confidence 0.04 Published 2007 Journal Nutr J Section Body Doc Link PMC2147024 Disease Relevance 0 Pain Relevance 0.04

General Comments

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