INT87823

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.66
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 51
Total Number 51
Disease Relevance 35.47
Pain Relevance 14.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl2) extracellular region (Cxcl2)
Anatomy Link Frequency
macrophage 5
neutrophil 4
monocyte 3
lung 3
plasma 2
Cxcl2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1087 100.00 Very High Very High Very High
cytokine 633 100.00 Very High Very High Very High
chemokine 413 100.00 Very High Very High Very High
Inflammatory mediators 41 100.00 Very High Very High Very High
substance P 1 99.80 Very High Very High Very High
Nicotine 121 99.46 Very High Very High Very High
Arthritis 125 99.44 Very High Very High Very High
agonist 117 98.44 Very High Very High Very High
ischemia 135 96.72 Very High Very High Very High
Paracetamol 34 96.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1156 100.00 Very High Very High Very High
Apoptosis 145 99.92 Very High Very High Very High
Sprains And Strains 256 99.68 Very High Very High Very High
Cancer 184 99.52 Very High Very High Very High
Influenza Virus Infection 200 99.48 Very High Very High Very High
Arthritis 137 99.44 Very High Very High Very High
Injury 698 98.92 Very High Very High Very High
Aids-related Complex 142 98.80 Very High Very High Very High
Pseudomonas Infection 10 98.40 Very High Very High Very High
Necrosis 82 98.06 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In an experimental Pseudomonas aeruginosa keratitis study, the susceptibility to infection by Pseudomonas aeruginosa was shown to involve dysregulation of the local host response including persistence of PMNs and increased levels of IL-1 and MIP-2.
Positive_regulation (increased) of MIP-2 associated with pseudomonas infection, keratitis and infection
1) Confidence 0.66 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 2.09 Pain Relevance 0.42
IL-1b was increased at 1 h, whereas IL-6, MIP-2, and MCP-1 were increased by 4-8 h.
Positive_regulation (increased) of MIP-2
2) Confidence 0.48 Published 2003 Journal Toxicol. Sci. Section Abstract Doc Link 12883092 Disease Relevance 0.26 Pain Relevance 0.95
In the A/J GMA-SS-exposed lung, the top network included 22 significantly upregulated focus molecules such as inflammatory chemokines regulating cell (monocyte, natural killer, and neutrophil) movement such as CCL2 and CCL4 and CXCL2 (Figure 6, panel A).
Positive_regulation (upregulated) of CXCL2 in monocyte associated with chemokine, inflammation and aids-related complex
3) Confidence 0.47 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 1.11 Pain Relevance 0.13
By 16 weeks, the majority of these genes were not differentially expressed in the B6 lung and the cancer category then included upregulated chemotactic genes (CCL2, CXCL2) which reflected the cell movement molecular and cellular function (Table 2).
Positive_regulation (upregulated) of CXCL2 in lung associated with cancer
4) Confidence 0.47 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 1.36 Pain Relevance 0.04
In the current study, similar to the above noted cytokines, a significant increase in MIP-2 levels was observed in the I/R treated group compared to the sham group (Figure 6).
Positive_regulation (increase) of MIP-2 associated with cytokine
5) Confidence 0.45 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1764413 Disease Relevance 0.10 Pain Relevance 0.10
The local effect of radiotherapy on an exposed segment of small bowel includes early increases in MIP-2 levels, a decrease in CD 45 positive cells over time and increased dose dependent apoptosis.
Positive_regulation (increases) of MIP-2 in bowel associated with apoptosis
6) Confidence 0.44 Published 2008 Journal BMC Surg Section Body Doc Link PMC2248567 Disease Relevance 0.45 Pain Relevance 0.26
MIP-2 (macrophage inflammatory protein) concentration was significantly increased in irradiated animals up to 48 hours.
Positive_regulation (increased) of MIP-2 in macrophage associated with inflammation
7) Confidence 0.44 Published 2008 Journal BMC Surg Section Abstract Doc Link PMC2248567 Disease Relevance 0.82 Pain Relevance 0.13
In our model there was a successive elevation of all MIP-2 levels up to 24 hours after which the irradiated groups generally maintained their levels whilst the sham levels dropped at 48 hours. 19 Gy irradiation being significantly raised compared to sham treatment at this time point.
Positive_regulation (elevation) of MIP-2
8) Confidence 0.44 Published 2008 Journal BMC Surg Section Body Doc Link PMC2248567 Disease Relevance 0.55 Pain Relevance 0.24
MIP-2 (macrophage inflammatory protein) concentration was significantly increased in irradiated animals up to 48 hours.
Positive_regulation (increased) of macrophage inflammatory protein in macrophage associated with inflammation
9) Confidence 0.44 Published 2008 Journal BMC Surg Section Abstract Doc Link PMC2248567 Disease Relevance 0.82 Pain Relevance 0.13
Levels of CXCR2 chemokine ligands at earlier timepoints showed only a small increase (two-fold) in the induction of KC/CXCL1 and MIP-2/CXCL2/3 as early as 4 h following dsRNA-exposure (data not shown), but the maximal increase (>ten-fold for KC/CXCL1 and >four-fold for MIP-2/CXCL2/3) occurred at 72 h following dsRNA-exposure.


Positive_regulation (induction) of MIP-2/CXCL2/3 associated with chemokine
10) Confidence 0.40 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.13 Pain Relevance 0.16
One explanation may be that the cholinergic agonist treatment did not sufficiently abolish CXC chemokine production and that the generated MIP-2 was able to trigger neutrophil infiltration and liver injury.
Positive_regulation (generated) of MIP-2 in neutrophil associated with chemokine, injury and agonist
11) Confidence 0.39 Published 2006 Journal BMC Clin Pathol Section Body Doc Link PMC1382240 Disease Relevance 1.19 Pain Relevance 0.56
expression can serve as a long-lasting stimulus for MIP-2 and KC induction as well as neutrophil recruitment to the brain.
Positive_regulation (induction) of MIP-2 in brain
12) Confidence 0.39 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 0.52 Pain Relevance 0.28
Two hours after irradiation there was a significant increase in MIP-2 in 38 Gy group compared to 19 Gy group (Figure 5). 24 hours after irradiation there was no difference between the groups. 48 hours after irradiation, there was an increase in both irradiated groups with a significant difference in the 19 Gy group compared to sham irradiated group.
Positive_regulation (increase) of MIP-2
13) Confidence 0.39 Published 2008 Journal BMC Surg Section Body Doc Link PMC2248567 Disease Relevance 0.11 Pain Relevance 0.08
Similar to the other cytokines noted above, plasma chemokine MIP-2 level significantly increased in vehicle-treated mice after 3 and 6 h of reperfusion, then decreased by 24 h (Figure 5).
Positive_regulation (increased) of MIP-2 in plasma associated with chemokine and cytokine
14) Confidence 0.34 Published 2006 Journal BMC Clin Pathol Section Body Doc Link PMC1382240 Disease Relevance 0.37 Pain Relevance 0.58
MIP-2 was upregulated in both groups in the early stage and returned to baseline on day 14.


Positive_regulation (upregulated) of MIP-2
15) Confidence 0.34 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2779062 Disease Relevance 0.21 Pain Relevance 0
Specifically, the high up-regulation of several chemokines (CXCL2, CCL5, CXCL5, CXCL9, CXCL1 CXCL10) which control the recruitment of leukocytes to the vaccination site is important for the early phases of the immune response [45].
Positive_regulation (regulation) of CXCL2 in leukocytes associated with chemokine
16) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748717 Disease Relevance 0.25 Pain Relevance 0.18
Mechanical ventilation alone significantly increased MIP-2 and TNF?
Positive_regulation (increased) of MIP-2
17) Confidence 0.33 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2873469 Disease Relevance 0.10 Pain Relevance 0.14
Serum levels of TNF-alpha and the C-X-C chemokines KC and MIP-2 increased by 28-, 14-, and 295-fold, respectively, over levels found in controls during the injury process.
Positive_regulation (increased) of MIP-2 associated with chemokine and injury
18) Confidence 0.33 Published 2000 Journal Toxicol. Sci. Section Abstract Doc Link 10774834 Disease Relevance 0.78 Pain Relevance 0.55
In particular, there was an increase in MIP-2 levels at all time-points excluding the zero time-point.
Positive_regulation (increase) of MIP-2
19) Confidence 0.30 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1764413 Disease Relevance 0.09 Pain Relevance 0.09
This enhanced response is associated with increases in the level of neutrophil-attracting chemokines KC and MIP-2, known to play a role in adhesiogenesis.
Positive_regulation (increases) of MIP-2 in neutrophil associated with chemokine
20) Confidence 0.30 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18453619 Disease Relevance 0.97 Pain Relevance 0.12

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox