INT87838

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 0.74
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Dcn) aging (Dcn) extracellular region (Dcn)
proteinaceous extracellular matrix (Dcn)
Anatomy Link Frequency
neurons 4
cartilage 1
temporomandibular joint 1
eyelid 1
neuropil 1
Dcn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcium channel 12 99.98 Very High Very High Very High
Snapping jaw 7 99.16 Very High Very High Very High
long-term potentiation 9 86.28 High High
depression 46 83.28 Quite High
Central nervous system 6 79.60 Quite High
Action potential 3 66.88 Quite High
Pain 3 47.44 Quite Low
GABAergic 3 38.20 Quite Low
substantia gelatinosa 6 35.64 Quite Low
tetrodotoxin 18 30.32 Quite Low
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 7 99.16 Very High Very High Very High
Osteoarthritis 1 96.68 Very High Very High Very High
Depression 46 83.28 Quite High
Pain 3 47.44 Quite Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Camurati-engelmann Disease 4 5.00 Very Low Very Low Very Low
Dislocations 3 5.00 Very Low Very Low Very Low
Decapitation 3 5.00 Very Low Very Low Very Low
Aging 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In limb articular cartilage, there is evidence that decorin synthesis increases with age and that it is elevated in response to increased loading or in osteoarthritic cartilage.
Gene_expression (synthesis) of decorin in cartilage associated with osteoarthritis
1) Confidence 0.75 Published 2000 Journal Arch. Oral Biol. Section Abstract Doc Link 10775677 Disease Relevance 0.26 Pain Relevance 0.16
Biochemical and immunohistochemical studies of the protein expression and localization of decorin and biglycan in the temporomandibular joint disc of growing rats.
Gene_expression (expression) of decorin in temporomandibular joint associated with snapping jaw
2) Confidence 0.65 Published 2002 Journal Arch. Oral Biol. Section Title Doc Link 12102764 Disease Relevance 0.19 Pain Relevance 0.24
For example, it has been shown that decreases in endogenous NO in the interposed nucleus of the DCN delayed classical eyelid conditioning (Allen & Steinmetz, 1996).
Gene_expression (nucleus) of DCN in eyelid
3) Confidence 0.19 Published 2010 Journal The European Journal of Neuroscience Section Body Doc Link PMC2955965 Disease Relevance 0.15 Pain Relevance 0.27
Presumably, the channels are located on the more distal processes that are shorn off during the isolation procedure, an interpretation consistent with immunocytochemical findings that the HCN channel protein in the DCN is concentrated in the neuropil (Notomi & Shigemoto, 2004).
Gene_expression (concentrated) of DCN in neuropil
4) Confidence 0.19 Published 2010 Journal The European Journal of Neuroscience Section Body Doc Link PMC2955965 Disease Relevance 0 Pain Relevance 0
Despite success in the biochemical assay, the new solution failed to confer sensitivity of Ih in DCN neurones to exogenous NO, when the donor was either DEA/NO (50 ?
Gene_expression (neurones) of DCN
5) Confidence 0.19 Published 2010 Journal The European Journal of Neuroscience Section Body Doc Link PMC2955965 Disease Relevance 0 Pain Relevance 0
Despite our lack of knowledge about detailed convergence patterns of PCs onto DCN neurons, convergence is more likely for adjacent pairs, where we observed coincident patterns, than for distant pairs which did not show synchronization.
Gene_expression (neurons) of DCN in neurons
6) Confidence 0.17 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1868782 Disease Relevance 0 Pain Relevance 0
Our simulations of the effect of regular patterns on Gsyn in downstream DCN neurons indicate that they keep inhibitory conductance fairly constant.
Gene_expression (neurons) of DCN in neurons
7) Confidence 0.17 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1868782 Disease Relevance 0.07 Pain Relevance 0.04
This indicates that tactile stimulation further reduced the variability of Gsyn in DCN neurons by an increased regularity of PC spike timing.


Gene_expression (neurons) of DCN in neurons
8) Confidence 0.17 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1868782 Disease Relevance 0 Pain Relevance 0
Because the inactivation of calcium channels expressed in the DCN neurons is strongly voltage dependent in the relevant potential range [41], these channels are very sensitive to even small changes in inhibitory input.
Gene_expression (expressed) of DCN in neurons associated with calcium channel
9) Confidence 0.17 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1868782 Disease Relevance 0.07 Pain Relevance 0.09

General Comments

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