INT8784

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Context Info
Confidence 0.59
First Reported 1989
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 40
Total Number 40
Disease Relevance 14.67
Pain Relevance 33.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) aging (Calca) extracellular region (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
plasma 10
neurons 6
DRG 6
renal pelvis 4
trigeminal ganglion 4
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 216 100.00 Very High Very High Very High
qutenza 132 100.00 Very High Very High Very High
bradykinin 11 100.00 Very High Very High Very High
Opioid 11 100.00 Very High Very High Very High
Dynorphin 6 100.00 Very High Very High Very High
Physical dependence 2 100.00 Very High Very High Very High
agonist 16 99.98 Very High Very High Very High
orphanin 13 99.98 Very High Very High Very High
dorsal root ganglion 12 99.84 Very High Very High Very High
Arthritis 4 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypertension 11 100.00 Very High Very High Very High
Heart Rate Under Development 3 100.00 Very High Very High Very High
Drug Dependence 2 100.00 Very High Very High Very High
INFLAMMATION 27 99.86 Very High Very High Very High
Ganglion Cysts 15 99.84 Very High Very High Very High
Arthritis 5 99.82 Very High Very High Very High
Rheumatoid Arthritis 10 99.52 Very High Very High Very High
Fever 2 99.50 Very High Very High Very High
Nervous System Injury 3 99.24 Very High Very High Very High
Cluster Headache 7 99.18 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The gangliosym-pathectomy abolished the increase in the CGRP levels.
Negative_regulation (abolished) of Positive_regulation (increase) of CGRP associated with calcitonin gene-related peptide
1) Confidence 0.59 Published 1996 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 8957683 Disease Relevance 0 Pain Relevance 1.48
The antimigraine drugs sumatriptan and dihydroergotamine block the development of plasma extravasation and ultrastructural changes, as well as plasma calcitonin gene-related peptide (CGRP) increase in the superior sagittal sinus following electrical trigeminal ganglion stimulation.
Negative_regulation (block) of Positive_regulation (increase) of plasma calcitonin gene-related peptide in trigeminal ganglion associated with ganglion cysts, cluster headache, sumatriptan, trigeminal ganglion and calcitonin gene-related peptide
2) Confidence 0.59 Published 1992 Journal Pathol. Biol. Section Abstract Doc Link 1379707 Disease Relevance 0.62 Pain Relevance 0.59
[Antiinflammatory drugs inhibit the elevation of plasma CGRP concentration in endotoxin shock in rats].
Negative_regulation (inhibit) of Positive_regulation (elevation) of CGRP in plasma associated with inflammation, shock and narcan
3) Confidence 0.59 Published 1991 Journal Sheng Li Xue Bao Section Title Doc Link 1754906 Disease Relevance 0.45 Pain Relevance 0.36
The sensory neurotoxin capsaicin prevented the expected increases of CGRP and substance P in the submandibular glands and of VIP in the parotid glands.
Negative_regulation (prevented) of Positive_regulation (increases) of CGRP in parotid glands associated with qutenza, substance p and calcitonin gene-related peptide
4) Confidence 0.57 Published 2005 Journal Arch. Oral Biol. Section Abstract Doc Link 16137500 Disease Relevance 0.09 Pain Relevance 0.83
Incubation with either spironolactone (1 microM), glibenclamide (10 microM), RU 486 10 microM, ODQ (10 microM) or cycloheximide (10 microM) significantly reduced the enhancement of CGRP-relaxation produced by aldosterone, while remained unmodified by SQ 22,536.
Negative_regulation (reduced) of Positive_regulation (enhancement) of CGRP
5) Confidence 0.57 Published 2004 Journal Regul. Pept. Section Body Doc Link 15177944 Disease Relevance 0.07 Pain Relevance 0
Trpv1-deficient DRG showed reduced CGRP increase by acid.
Negative_regulation (reduced) of Positive_regulation (increase) of CGRP in DRG associated with dorsal root ganglion and calcitonin gene-related peptide
6) Confidence 0.56 Published 2010 Journal Mol. Biol. Cell Section Abstract Doc Link 20534813 Disease Relevance 1.20 Pain Relevance 1.40
The arthritis-induced increase in the content of iCGRP in the dorsal root ganglia was significantly reduced after treatment with the antiinflammatory analgesic, diclofenac sodium, in a dose of 3 mg/kg/day, PO for 10 days.
Negative_regulation (reduced) of Positive_regulation (increase) of iCGRP in dorsal root ganglia associated with inflammation, analgesic, diclofenac and arthritis
7) Confidence 0.51 Published 1989 Journal Peptides Section Abstract Doc Link 2787910 Disease Relevance 0.92 Pain Relevance 0.71
In proximal stump tips of rat sciatic nerves transected 48 h earlier, CGRP accumulation colocalized with a label for neurofilament that was accentuated at axon tips, but was prevented by a concurrent more proximal sciatic section.
Negative_regulation (prevented) of Positive_regulation (accumulation) of CGRP in proximal associated with sciatic nerve and calcitonin gene-related peptide
8) Confidence 0.51 Published 2001 Journal Brain Res. Section Abstract Doc Link 11376593 Disease Relevance 0.14 Pain Relevance 0.52
Recent evidence suggests that both the opioid-induced increase in CGRP and the development of opioid physical dependence are suppressed by blockade of spinal cannabinoid (CB1)-receptors.
Negative_regulation (suppressed) of Positive_regulation (increase) of CGRP in spinal associated with physical dependence, cannabinoid, opioid and calcitonin gene-related peptide
9) Confidence 0.50 Published 2007 Journal Neuroscience Section Abstract Doc Link 17395382 Disease Relevance 0.20 Pain Relevance 1.78
Increased plasma calcitonin gene-related peptide levels induced by capsaicin (68.9+/-2.8 pg/mL) perfusion into the renal pelvis was prevented either by capsazepine (22.5+/-10.1 pg/mL) given ipsilaterally into the renal pelvis or by ipsilateral renal denervation (25.9+/-2.3 pg/mL).
Negative_regulation (prevented) of Positive_regulation (induced) of calcitonin in renal pelvis associated with qutenza and calcitonin gene-related peptide
10) Confidence 0.44 Published 2005 Journal Hypertension Section Abstract Doc Link 16087784 Disease Relevance 0.44 Pain Relevance 0.64
The results showed that indomethacin, ibuprofen and naloxone significantly inhibited the elevation of plasma CGRP concentration as well as reduced the lesion in the intestine during endotoxin shock.
Negative_regulation (inhibited) of Positive_regulation (elevation) of CGRP in intestine associated with shock and narcan
11) Confidence 0.43 Published 1991 Journal Sheng Li Xue Bao Section Abstract Doc Link 1754906 Disease Relevance 0.43 Pain Relevance 0.32
Rutaecarpine significantly increased the plasma concentration of CGRP, which was also abolished by capsazepine.
Negative_regulation (abolished) of Positive_regulation (increased) of CGRP in plasma associated with calcitonin gene-related peptide
12) Confidence 0.43 Published 2005 Journal Planta Med. Section Abstract Doc Link 15931578 Disease Relevance 0.72 Pain Relevance 0.59
After pretreatment with capsaicin to deplete the sensory nerve transmitter content, the cardioprotection and the increased level of CGRP by capsaicin were abolished.
Negative_regulation (abolished) of Positive_regulation (increased) of CGRP in sensory nerve
13) Confidence 0.43 Published 1999 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 11270991 Disease Relevance 0 Pain Relevance 0
In SHR and WKY preparations, PNS (4 and 8 Hz) evoked a frequency-dependent increase of CGRP-LI in the perfusate, which was abolished by 500 nM tetrodotoxin and the removal of Ca2+ from the medium.
Negative_regulation (abolished) of Positive_regulation (increase) of CGRP associated with tetrodotoxin and calcitonin gene-related peptide
14) Confidence 0.43 Published 1992 Journal Clin Exp Hypertens A Section Abstract Doc Link 1424225 Disease Relevance 0.16 Pain Relevance 0.49
In isolated perfused stomach from normal rats, acute arterial infusion of capsaicin significantly reduced the perfusion pressure of the left gastric artery, with a simultaneous increase in CGRP and somatostatin secretion.
Negative_regulation (reduced) of Positive_regulation (increase) of CGRP in stomach associated with qutenza, somatostatin and calcitonin gene-related peptide
15) Confidence 0.43 Published 1993 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 7904285 Disease Relevance 0 Pain Relevance 1.21
Decreased CGRP level with increased sensitivity to CGRP in the pial arteries of spontaneously hypertensive rats.
Negative_regulation (Decreased) of Positive_regulation (increased) of CGRP associated with qutenza and hypertension
16) Confidence 0.43 Published 1997 Journal Life Sci. Section Title Doc Link 9064474 Disease Relevance 0.37 Pain Relevance 0.62
Chronic administration of Rut (10, 20, or 40 mg/kg/day, respectively) for 4 weeks caused a depressor effect and significantly regressed the lumen diameter and decreased the medium thickness of mesenteric arteries in hypertensive rats concomitantly with an increase in the plasma concentration of CGRP and the expression of CGRP mRNA in DRG.
Negative_regulation (decreased) of Positive_regulation (increase) of CGRP in DRG associated with hypertension and calcitonin gene-related peptide
17) Confidence 0.43 Published 2007 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 18091582 Disease Relevance 0.56 Pain Relevance 0.53
Inhibition of low threshold T-type calcium channels by mibefradil (10 microM) significantly reduced potassium (by 47%) but not capsaicin-stimulated iCGRP release.
Neg (not) Negative_regulation (reduced) of Neg (not) Positive_regulation (capsaicin-stimulated) of iCGRP associated with qutenza and calcium channel
18) Confidence 0.43 Published 2008 Journal Neuroscience Section Abstract Doc Link 18178321 Disease Relevance 0 Pain Relevance 1.33
Reduction of total sodium channel conductance by tetrodotoxin (1 microM), lidocaine (10 microM, 50 microM or 500 microM) or by replacement of extracellular sodium with choline-chloride did not result in a reduction of either potassium- or capsaicin-induced axonal iCGRP release.
Negative_regulation (reduction) of Positive_regulation (capsaicin-induced) of iCGRP associated with tetrodotoxin, qutenza, sodium channel and lidocaine
19) Confidence 0.43 Published 2008 Journal Neuroscience Section Abstract Doc Link 18178321 Disease Relevance 0 Pain Relevance 1.26
Interestingly, however, D600 was unable to reduce the capsaicin-induced iCGRP release.
Neg (unable) Negative_regulation (reduce) of Positive_regulation (capsaicin-induced) of iCGRP associated with qutenza
20) Confidence 0.43 Published 2008 Journal Neuroscience Section Abstract Doc Link 18178321 Disease Relevance 0 Pain Relevance 1.06

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