INT8784
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
The gangliosym-pathectomy abolished the increase in the CGRP levels. | |||||||||||||||
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The antimigraine drugs sumatriptan and dihydroergotamine block the development of plasma extravasation and ultrastructural changes, as well as plasma calcitonin gene-related peptide (CGRP) increase in the superior sagittal sinus following electrical trigeminal ganglion stimulation. | |||||||||||||||
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[Antiinflammatory drugs inhibit the elevation of plasma CGRP concentration in endotoxin shock in rats]. | |||||||||||||||
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The sensory neurotoxin capsaicin prevented the expected increases of CGRP and substance P in the submandibular glands and of VIP in the parotid glands. | |||||||||||||||
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Incubation with either spironolactone (1 microM), glibenclamide (10 microM), RU 486 10 microM, ODQ (10 microM) or cycloheximide (10 microM) significantly reduced the enhancement of CGRP-relaxation produced by aldosterone, while remained unmodified by SQ 22,536. | |||||||||||||||
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Trpv1-deficient DRG showed reduced CGRP increase by acid. | |||||||||||||||
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The arthritis-induced increase in the content of iCGRP in the dorsal root ganglia was significantly reduced after treatment with the antiinflammatory analgesic, diclofenac sodium, in a dose of 3 mg/kg/day, PO for 10 days. | |||||||||||||||
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In proximal stump tips of rat sciatic nerves transected 48 h earlier, CGRP accumulation colocalized with a label for neurofilament that was accentuated at axon tips, but was prevented by a concurrent more proximal sciatic section. | |||||||||||||||
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Recent evidence suggests that both the opioid-induced increase in CGRP and the development of opioid physical dependence are suppressed by blockade of spinal cannabinoid (CB1)-receptors. | |||||||||||||||
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Increased plasma calcitonin gene-related peptide levels induced by capsaicin (68.9+/-2.8 pg/mL) perfusion into the renal pelvis was prevented either by capsazepine (22.5+/-10.1 pg/mL) given ipsilaterally into the renal pelvis or by ipsilateral renal denervation (25.9+/-2.3 pg/mL). | |||||||||||||||
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The results showed that indomethacin, ibuprofen and naloxone significantly inhibited the elevation of plasma CGRP concentration as well as reduced the lesion in the intestine during endotoxin shock. | |||||||||||||||
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Rutaecarpine significantly increased the plasma concentration of CGRP, which was also abolished by capsazepine. | |||||||||||||||
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After pretreatment with capsaicin to deplete the sensory nerve transmitter content, the cardioprotection and the increased level of CGRP by capsaicin were abolished. | |||||||||||||||
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In SHR and WKY preparations, PNS (4 and 8 Hz) evoked a frequency-dependent increase of CGRP-LI in the perfusate, which was abolished by 500 nM tetrodotoxin and the removal of Ca2+ from the medium. | |||||||||||||||
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In isolated perfused stomach from normal rats, acute arterial infusion of capsaicin significantly reduced the perfusion pressure of the left gastric artery, with a simultaneous increase in CGRP and somatostatin secretion. | |||||||||||||||
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Decreased CGRP level with increased sensitivity to CGRP in the pial arteries of spontaneously hypertensive rats. | |||||||||||||||
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Chronic administration of Rut (10, 20, or 40 mg/kg/day, respectively) for 4 weeks caused a depressor effect and significantly regressed the lumen diameter and decreased the medium thickness of mesenteric arteries in hypertensive rats concomitantly with an increase in the plasma concentration of CGRP and the expression of CGRP mRNA in DRG. | |||||||||||||||
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Inhibition of low threshold T-type calcium channels by mibefradil (10 microM) significantly reduced potassium (by 47%) but not capsaicin-stimulated iCGRP release. | |||||||||||||||
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Reduction of total sodium channel conductance by tetrodotoxin (1 microM), lidocaine (10 microM, 50 microM or 500 microM) or by replacement of extracellular sodium with choline-chloride did not result in a reduction of either potassium- or capsaicin-induced axonal iCGRP release. | |||||||||||||||
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Interestingly, however, D600 was unable to reduce the capsaicin-induced iCGRP release. | |||||||||||||||
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General Comments
This test has worked.