INT8784

Context Info Confidence 0.59 First Reported 1989 Last Reported 2010 Negated 2 Speculated 0 Reported most in Abstract Documents 40 Total Number 40 Disease Relevance 14.67 Pain Relevance 33.49

extracellular space (Calca) aging (Calca) extracellular region (Calca) nucleus (Calca) intracellular (Calca) cytoplasm (Calca)

Anatomy Link Frequency plasma 10 neurons 6 DRG 6 renal pelvis 4 trigeminal ganglion 4 Calca (Rattus norvegicus)

Pain Link Frequency Relevance Heat Calcitonin gene-related peptide 216 100.00 qutenza 132 100.00 bradykinin 11 100.00 Opioid 11 100.00 Dynorphin 6 100.00 Physical dependence 2 100.00 agonist 16 99.98 orphanin 13 99.98 dorsal root ganglion 12 99.84 Arthritis 4 99.82

Disease Link Frequency Relevance Heat Hypertension 11 100.00 Heart Rate Under Development 3 100.00 Drug Dependence 2 100.00 INFLAMMATION 27 99.86 Ganglion Cysts 15 99.84 Arthritis 5 99.82 Rheumatoid Arthritis 10 99.52 Fever 2 99.50 Nervous System Injury 3 99.24 Cluster Headache 7 99.18

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The gangliosym-pathectomy abolished the increase in the CGRP levels.

Negative_regulation (abolished) of Positive_regulation (increase) of CGRP associated with calcitonin gene-related peptide

1) Confidence 0.59 Published 1996 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 8957683 Disease Relevance 0 Pain Relevance 1.48

The antimigraine drugs sumatriptan and dihydroergotamine block the development of plasma extravasation and ultrastructural changes, as well as plasma calcitonin gene-related peptide (CGRP) increase in the superior sagittal sinus following electrical trigeminal ganglion stimulation.

Negative_regulation (block) of Positive_regulation (increase) of plasma calcitonin gene-related peptide in trigeminal ganglion associated with ganglion cysts, cluster headache, sumatriptan, trigeminal ganglion and calcitonin gene-related peptide

2) Confidence 0.59 Published 1992 Journal Pathol. Biol. Section Abstract Doc Link 1379707 Disease Relevance 0.62 Pain Relevance 0.59

[Antiinflammatory drugs inhibit the elevation of plasma CGRP concentration in endotoxin shock in rats].

Negative_regulation (inhibit) of Positive_regulation (elevation) of CGRP in plasma associated with inflammation, shock and narcan

3) Confidence 0.59 Published 1991 Journal Sheng Li Xue Bao Section Title Doc Link 1754906 Disease Relevance 0.45 Pain Relevance 0.36

The sensory neurotoxin capsaicin prevented the expected increases of CGRP and substance P in the submandibular glands and of VIP in the parotid glands.

Negative_regulation (prevented) of Positive_regulation (increases) of CGRP in parotid glands associated with qutenza, substance p and calcitonin gene-related peptide

4) Confidence 0.57 Published 2005 Journal Arch. Oral Biol. Section Abstract Doc Link 16137500 Disease Relevance 0.09 Pain Relevance 0.83

Incubation with either spironolactone (1 microM), glibenclamide (10 microM), RU 486 10 microM, ODQ (10 microM) or cycloheximide (10 microM) significantly reduced the enhancement of CGRP-relaxation produced by aldosterone, while remained unmodified by SQ 22,536.

Negative_regulation (reduced) of Positive_regulation (enhancement) of CGRP

5) Confidence 0.57 Published 2004 Journal Regul. Pept. Section Body Doc Link 15177944 Disease Relevance 0.07 Pain Relevance 0

Trpv1-deficient DRG showed reduced CGRP increase by acid.

Negative_regulation (reduced) of Positive_regulation (increase) of CGRP in DRG associated with dorsal root ganglion and calcitonin gene-related peptide

6) Confidence 0.56 Published 2010 Journal Mol. Biol. Cell Section Abstract Doc Link 20534813 Disease Relevance 1.20 Pain Relevance 1.40

The arthritis-induced increase in the content of iCGRP in the dorsal root ganglia was significantly reduced after treatment with the antiinflammatory analgesic, diclofenac sodium, in a dose of 3 mg/kg/day, PO for 10 days.

Negative_regulation (reduced) of Positive_regulation (increase) of iCGRP in dorsal root ganglia associated with inflammation, analgesic, diclofenac and arthritis

7) Confidence 0.51 Published 1989 Journal Peptides Section Abstract Doc Link 2787910 Disease Relevance 0.92 Pain Relevance 0.71

In proximal stump tips of rat sciatic nerves transected 48 h earlier, CGRP accumulation colocalized with a label for neurofilament that was accentuated at axon tips, but was prevented by a concurrent more proximal sciatic section.

Negative_regulation (prevented) of Positive_regulation (accumulation) of CGRP in proximal associated with sciatic nerve and calcitonin gene-related peptide

8) Confidence 0.51 Published 2001 Journal Brain Res. Section Abstract Doc Link 11376593 Disease Relevance 0.14 Pain Relevance 0.52

Recent evidence suggests that both the opioid-induced increase in CGRP and the development of opioid physical dependence are suppressed by blockade of spinal cannabinoid (CB1)-receptors.

Negative_regulation (suppressed) of Positive_regulation (increase) of CGRP in spinal associated with physical dependence, cannabinoid, opioid and calcitonin gene-related peptide

9) Confidence 0.50 Published 2007 Journal Neuroscience Section Abstract Doc Link 17395382 Disease Relevance 0.20 Pain Relevance 1.78

Increased plasma calcitonin gene-related peptide levels induced by capsaicin (68.9+/-2.8 pg/mL) perfusion into the renal pelvis was prevented either by capsazepine (22.5+/-10.1 pg/mL) given ipsilaterally into the renal pelvis or by ipsilateral renal denervation (25.9+/-2.3 pg/mL).

Negative_regulation (prevented) of Positive_regulation (induced) of calcitonin in renal pelvis associated with qutenza and calcitonin gene-related peptide

10) Confidence 0.44 Published 2005 Journal Hypertension Section Abstract Doc Link 16087784 Disease Relevance 0.44 Pain Relevance 0.64

The results showed that indomethacin, ibuprofen and naloxone significantly inhibited the elevation of plasma CGRP concentration as well as reduced the lesion in the intestine during endotoxin shock.

Negative_regulation (inhibited) of Positive_regulation (elevation) of CGRP in intestine associated with shock and narcan

11) Confidence 0.43 Published 1991 Journal Sheng Li Xue Bao Section Abstract Doc Link 1754906 Disease Relevance 0.43 Pain Relevance 0.32

Rutaecarpine significantly increased the plasma concentration of CGRP, which was also abolished by capsazepine.

Negative_regulation (abolished) of Positive_regulation (increased) of CGRP in plasma associated with calcitonin gene-related peptide

12) Confidence 0.43 Published 2005 Journal Planta Med. Section Abstract Doc Link 15931578 Disease Relevance 0.72 Pain Relevance 0.59

After pretreatment with capsaicin to deplete the sensory nerve transmitter content, the cardioprotection and the increased level of CGRP by capsaicin were abolished.

Negative_regulation (abolished) of Positive_regulation (increased) of CGRP in sensory nerve

13) Confidence 0.43 Published 1999 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 11270991 Disease Relevance 0 Pain Relevance 0

In SHR and WKY preparations, PNS (4 and 8 Hz) evoked a frequency-dependent increase of CGRP-LI in the perfusate, which was abolished by 500 nM tetrodotoxin and the removal of Ca2+ from the medium.

Negative_regulation (abolished) of Positive_regulation (increase) of CGRP associated with tetrodotoxin and calcitonin gene-related peptide

14) Confidence 0.43 Published 1992 Journal Clin Exp Hypertens A Section Abstract Doc Link 1424225 Disease Relevance 0.16 Pain Relevance 0.49

In isolated perfused stomach from normal rats, acute arterial infusion of capsaicin significantly reduced the perfusion pressure of the left gastric artery, with a simultaneous increase in CGRP and somatostatin secretion.

Negative_regulation (reduced) of Positive_regulation (increase) of CGRP in stomach associated with qutenza, somatostatin and calcitonin gene-related peptide

15) Confidence 0.43 Published 1993 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 7904285 Disease Relevance 0 Pain Relevance 1.21

Decreased CGRP level with increased sensitivity to CGRP in the pial arteries of spontaneously hypertensive rats.

Negative_regulation (Decreased) of Positive_regulation (increased) of CGRP associated with qutenza and hypertension

16) Confidence 0.43 Published 1997 Journal Life Sci. Section Title Doc Link 9064474 Disease Relevance 0.37 Pain Relevance 0.62

Chronic administration of Rut (10, 20, or 40 mg/kg/day, respectively) for 4 weeks caused a depressor effect and significantly regressed the lumen diameter and decreased the medium thickness of mesenteric arteries in hypertensive rats concomitantly with an increase in the plasma concentration of CGRP and the expression of CGRP mRNA in DRG.

Negative_regulation (decreased) of Positive_regulation (increase) of CGRP in DRG associated with hypertension and calcitonin gene-related peptide

17) Confidence 0.43 Published 2007 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 18091582 Disease Relevance 0.56 Pain Relevance 0.53

Inhibition of low threshold T-type calcium channels by mibefradil (10 microM) significantly reduced potassium (by 47%) but not capsaicin-stimulated iCGRP release.

Neg (not) Negative_regulation (reduced) of Neg (not) Positive_regulation (capsaicin-stimulated) of iCGRP associated with qutenza and calcium channel

18) Confidence 0.43 Published 2008 Journal Neuroscience Section Abstract Doc Link 18178321 Disease Relevance 0 Pain Relevance 1.33

Reduction of total sodium channel conductance by tetrodotoxin (1 microM), lidocaine (10 microM, 50 microM or 500 microM) or by replacement of extracellular sodium with choline-chloride did not result in a reduction of either potassium- or capsaicin-induced axonal iCGRP release.

Negative_regulation (reduction) of Positive_regulation (capsaicin-induced) of iCGRP associated with tetrodotoxin, qutenza, sodium channel and lidocaine

19) Confidence 0.43 Published 2008 Journal Neuroscience Section Abstract Doc Link 18178321 Disease Relevance 0 Pain Relevance 1.26

Interestingly, however, D600 was unable to reduce the capsaicin-induced iCGRP release.

Neg (unable) Negative_regulation (reduce) of Positive_regulation (capsaicin-induced) of iCGRP associated with qutenza

20) Confidence 0.43 Published 2008 Journal Neuroscience Section Abstract Doc Link 18178321 Disease Relevance 0 Pain Relevance 1.06

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