INT87840

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Context Info
Confidence 0.08
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 0.30
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 2
hypothalamus 1
GABAergic neurons 1
SCO (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 11 99.90 Very High Very High Very High
Action potential 8 99.84 Very High Very High Very High
GABA receptor 4 99.44 Very High Very High Very High
Hippocampus 4 97.80 Very High Very High Very High
Neurotransmitter 41 95.44 Very High Very High Very High
GABAergic 12 93.16 High High
antagonist 28 85.24 High High
Potency 4 82.72 Quite High
Glutamate 20 79.76 Quite High
nMDA receptor 8 75.44 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 2 96.96 Very High Very High Very High
Hypoxia 1 87.60 High High
Depression 12 55.44 Quite High
Vibrio Infection 8 5.00 Very Low Very Low Very Low
Hypothermia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast with ATP and UTP, bath application of UDP facilitated the SCO (unpublished data); thus the involvement of P2Y6 receptors is ruled out.
Positive_regulation (facilitated) of SCO
1) Confidence 0.08 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0.28
Inhibition of GABA receptors by picrotoxin dramatically enhanced the SCO, however, addition of ATP or UTP still suppressed the SCO (Fig. 5 C), implying that under our experimental conditions the inhibitory effect of ATP/UTP is not mediated by GABAergic neurons.
Positive_regulation (enhanced) of SCO in GABAergic neurons associated with gabaergic and gaba receptor
2) Confidence 0.06 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0.06 Pain Relevance 0.21
As shown above, the SCO are generated due to Ca2+ entry through voltage-gated Ca2+ channels consequent to AMPA receptor activation during spontaneous activity in the neuronal network.
Positive_regulation (generated) of SCO in neuronal
3) Confidence 0.06 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0
SCO are triggered by action potential in the neuronal network.
Positive_regulation (triggered) of SCO in neuronal associated with action potential
4) Confidence 0.06 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0.28
In CLO and SCO rats mAch receptors were increased in cortex, and reduced in hypothalamus; I1-imidazoline receptors were increased in hypothalamus and decreased in hippocampus (p<0.05 for each).
Positive_regulation (increased) of SCO in hypothalamus associated with hippocampus and clonidine
5) Confidence 0.01 Published 2000 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 10775770 Disease Relevance 0.25 Pain Relevance 0.96

General Comments

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