INT87844

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Context Info
Confidence 0.41
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 40
Total Number 40
Disease Relevance 24.37
Pain Relevance 11.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL1RN) extracellular region (IL1RN) plasma membrane (IL1RN)
nucleus (IL1RN) intracellular (IL1RN) cytoplasm (IL1RN)
Anatomy Link Frequency
plasma 3
knee 2
tear 1
macrophages 1
skin 1
IL1RN (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 162 100.00 Very High Very High Very High
anakinra 52 100.00 Very High Very High Very High
cytokine 373 99.98 Very High Very High Very High
Pain 135 99.88 Very High Very High Very High
Osteoarthritis 1443 99.36 Very High Very High Very High
Inflammation 511 99.16 Very High Very High Very High
spinal inflammation 27 99.10 Very High Very High Very High
rheumatoid arthritis 274 98.70 Very High Very High Very High
Arthritis 84 98.14 Very High Very High Very High
Crohn's disease 5 98.02 Very High Very High Very High
Disease Link Frequency Relevance Heat
Infection 117 100.00 Very High Very High Very High
Arthralgia 16 100.00 Very High Very High Very High
Macrophage Activation Syndrome 21 99.70 Very High Very High Very High
Skin Diseases 2 99.60 Very High Very High Very High
Osteoarthritis 1445 99.36 Very High Very High Very High
INFLAMMATION 548 99.16 Very High Very High Very High
Low Back Pain 33 99.10 Very High Very High Very High
Disease 447 99.00 Very High Very High Very High
Ulcers 6 98.78 Very High Very High Very High
Rheumatoid Arthritis 282 98.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
that signal via the Type 1 IL-1 receptor and there is a specific Interleukin-1 receptor antagonist (IL-1ra), the only known naturally occurring cytokine antagonist, that inhibits IL-1 actions by binding to the Type 1 IL-1 Receptor (IL-1RI), blocking the receptor and preventing IL-1 from binding thereby preventing receptor signalling [7].


IL-1RI Binding (binding) of associated with antagonist and cytokine
1) Confidence 0.41 Published 2008 Journal Trials Section Body Doc Link PMC2289802 Disease Relevance 1.14 Pain Relevance 0.54
The IL-1RN*2 allele was not associated with any difference in clinical disease expression.
IL-1RN Binding (associated) of associated with disease
2) Confidence 0.36 Published 2008 Journal Clin. Rheumatol. Section Abstract Doc Link 17899305 Disease Relevance 1.06 Pain Relevance 0.68
binds IL-1RI on the surface of a variety of cells and initiates a cascade of events leading to recruitment and activation of macrophages and neutrophils.
IL-1RI Binding (binds) of in macrophages
3) Confidence 0.36 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.86 Pain Relevance 0.38
Our study found that variants at the IL-1ra gene associate with athletic status.
IL-1ra Binding (associate) of
4) Confidence 0.36 Published 2010 Journal BMC Med Genet Section Abstract Doc Link PMC2837019 Disease Relevance 0.07 Pain Relevance 0.09
In the experiments described here we have examined enzyme activity directed at degradation of collagen type II, gelatin and casein in intact normal and degenerate human AF and NP tissue, both with and without pretreatment with IL-1 and IL-1Ra.
IL-1Ra Binding (pretreatment) of
5) Confidence 0.33 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0 Pain Relevance 0
By contrast, IL-1Ra gave ?
IL-1Ra Binding (gave) of
6) Confidence 0.33 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0.07 Pain Relevance 0
The IL1-receptor antagonist is commercially available and approved for use in specific inflammatory conditions.
IL1-receptor Binding (approved) of associated with inflammation and antagonist
7) Confidence 0.31 Published 2008 Journal Trials Section Body Doc Link PMC2289802 Disease Relevance 0.10 Pain Relevance 0.10
Patient one had no LFT elevations prior to treatment with IL1RA, while patient 2 had mild transaminitis with MAS just prior to initiation of IL1RA, and patient 3 had multiple bouts of transaminitis with flu-like illnesses both before and after her acute hepatitis (Figure 2A).
IL1RA Binding (initiation) of associated with macrophage activation syndrome and hepatitis
8) Confidence 0.30 Published 2009 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2805658 Disease Relevance 1.18 Pain Relevance 0.10
Also, opposite to findings by Smith et al.[29], we did not find LD between SNPs in IL1R1 and the locus containing IL1A, IL1B, and IL1RN in our study material (r2 ?
IL1RN Binding (material) of
9) Confidence 0.30 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2859817 Disease Relevance 0.57 Pain Relevance 0.24
In addition, the concentration of IL-1 receptor antagonist (IL-1RA), which competes for receptor binding with IL-1, was also found to be increased in Gambian children with cerebral malaria [4].
IL-1RA Binding (binding) of associated with antagonist and cerebral malaria
10) Confidence 0.29 Published 2005 Journal Malar J Section Body Doc Link PMC1224865 Disease Relevance 0.70 Pain Relevance 0.13
The IL1-receptor antagonist is commercially available and approved for use in specific inflammatory conditions.
antagonist Binding (approved) of associated with inflammation and antagonist
11) Confidence 0.27 Published 2008 Journal Trials Section Body Doc Link PMC2289802 Disease Relevance 0.10 Pain Relevance 0.10
that signal via the Type 1 IL-1 receptor and there is a specific Interleukin-1 receptor antagonist (IL-1ra), the only known naturally occurring cytokine antagonist, that inhibits IL-1 actions by binding to the Type 1 IL-1 Receptor (IL-1RI), blocking the receptor and preventing IL-1 from binding thereby preventing receptor signalling [7].


antagonist Binding (binding) of associated with antagonist and cytokine
12) Confidence 0.26 Published 2008 Journal Trials Section Body Doc Link PMC2289802 Disease Relevance 1.10 Pain Relevance 0.55
These data confirm that S. gordonii may represent a reliable system to deliver a drug molecule, such as IL-1ra, to target mucosal sites.


IL-1ra Binding (deliver) of
13) Confidence 0.26 Published 2003 Journal BMC Biotechnol Section Body Doc Link PMC222906 Disease Relevance 0.49 Pain Relevance 0.05
OBJECTIVE: Since ulcerative colitis and Crohn's disease, which are associated with ankylosing spondylitis (AS), have been found to be variably associated with the IL-1B and the IL-1RN genes encoding interleukin-1beta (IL-1beta) and the interleukin-1 receptor antagonist (IL-1ra), we have investigated whether these polymorphisms in IL-1B and IL-1RN are also involved in AS.
IL-1ra Binding (associated) of associated with spinal inflammation, inflammatory bowel disease, crohn's disease, antagonist and disease
14) Confidence 0.20 Published 2002 Journal Rheumatology (Oxford) Section Abstract Doc Link 12468823 Disease Relevance 0.57 Pain Relevance 0.51
OBJECTIVE: Since ulcerative colitis and Crohn's disease, which are associated with ankylosing spondylitis (AS), have been found to be variably associated with the IL-1B and the IL-1RN genes encoding interleukin-1beta (IL-1beta) and the interleukin-1 receptor antagonist (IL-1ra), we have investigated whether these polymorphisms in IL-1B and IL-1RN are also involved in AS.
interleukin-1 receptor antagonist Binding (associated) of associated with spinal inflammation, inflammatory bowel disease, crohn's disease, antagonist and disease
15) Confidence 0.20 Published 2002 Journal Rheumatology (Oxford) Section Abstract Doc Link 12468823 Disease Relevance 0.57 Pain Relevance 0.51
OBJECTIVE: Since ulcerative colitis and Crohn's disease, which are associated with ankylosing spondylitis (AS), have been found to be variably associated with the IL-1B and the IL-1RN genes encoding interleukin-1beta (IL-1beta) and the interleukin-1 receptor antagonist (IL-1ra), we have investigated whether these polymorphisms in IL-1B and IL-1RN are also involved in AS.
IL-1RN Binding (associated) of associated with spinal inflammation, inflammatory bowel disease, crohn's disease, antagonist and disease
16) Confidence 0.20 Published 2002 Journal Rheumatology (Oxford) Section Abstract Doc Link 12468823 Disease Relevance 0.56 Pain Relevance 0.50
CONCLUSION: Similar to other chronic inflammatory diseases, AS is associated with the IL-1RN*2 allele.
IL-1RN Binding (associated) of
17) Confidence 0.20 Published 2002 Journal Rheumatology (Oxford) Section Body Doc Link 12468823 Disease Relevance 0.07 Pain Relevance 0
However, IL-1Ra also binds the sIL-1R, and the binding affinity of sIL1R to both IL-1 isoforms and IL-1Ra differs.
IL-1Ra Binding (binds) of
18) Confidence 0.13 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526599 Disease Relevance 0.22 Pain Relevance 0.27
binds IL-1RI on the surface of a variety of cells and initiates a cascade of events leading to recruitment and activation of macrophages and neutrophils.
IL-1RI Binding (binds) of in neutrophils
19) Confidence 0.12 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.86 Pain Relevance 0.38
Among these, IL-1Ra (see above) has been extensively tested for its ability to counteract the process of OA.
IL-1Ra Binding (counteract) of associated with osteoarthritis
20) Confidence 0.10 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526599 Disease Relevance 0.38 Pain Relevance 0.20

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