INT87847

Context Info Confidence 0.36 First Reported 2000 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 1.49 Pain Relevance 0.43

intracellular (Rac1) enzyme binding (Rac1) GTPase activity (Rac1) cytoplasm (Rac1) cell proliferation (Rac1) cell motility (Rac1)

Anatomy Link Frequency nerve 2 brain 2 Rac1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat ischemia 86 99.96 nerve block 1 95.36 Bile 2 89.76 Hippocampus 17 76.44 imagery 2 63.20 anesthesia 4 5.00 Pyramidal cell 3 5.00 isoflurane 3 5.00 cerebral cortex 2 5.00 Intracerebroventricular 2 5.00

Disease Link Frequency Relevance Heat Cv General 4 Under Development 55 99.96 Increased Venous Pressure Under Development 1 99.16 Cancer 4 97.68 Death 19 93.12 Pancreatic Cancer 1 92.76 Peptic Ulcer 1 88.08 Malignant Neoplastic Disease 1 85.96 Biliary Cancer 1 79.96 Carcinoma 1 76.08 Apoptosis 6 60.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Rac1 GTPase activation has been suggested to be critical for NADPH oxidase activation in immune cells and may have a similar role in the brain.

Regulation (critical) of Positive_regulation (activation) of Rac1 in brain

1) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 0.67 Pain Relevance 0.22

This new technique may also be used for the intrasphincteric injection of botulinum toxin in the treatment of achalasia, for the steroid injection treatment of refractory esophageal strictures, for celiac nerve block, for pseudocyst drainage, and for drug delivery into pancreatic tumors.

Regulation (used) of Positive_regulation (injection) of botulinum toxin in nerve associated with nerve block, pancreatic cancer and increased venous pressure under development

2) Confidence 0.36 Published 2000 Journal J. Gastroenterol. Section Abstract Doc Link 10777153 Disease Relevance 0.82 Pain Relevance 0.21

General Comments

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