INT87847

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Context Info
Confidence 0.36
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.49
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Rac1) enzyme binding (Rac1) GTPase activity (Rac1)
cytoplasm (Rac1) cell proliferation (Rac1) cell motility (Rac1)
Anatomy Link Frequency
nerve 2
brain 2
Rac1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 86 99.96 Very High Very High Very High
nerve block 1 95.36 Very High Very High Very High
Bile 2 89.76 High High
Hippocampus 17 76.44 Quite High
imagery 2 63.20 Quite High
anesthesia 4 5.00 Very Low Very Low Very Low
Pyramidal cell 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Intracerebroventricular 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 55 99.96 Very High Very High Very High
Increased Venous Pressure Under Development 1 99.16 Very High Very High Very High
Cancer 4 97.68 Very High Very High Very High
Death 19 93.12 High High
Pancreatic Cancer 1 92.76 High High
Peptic Ulcer 1 88.08 High High
Malignant Neoplastic Disease 1 85.96 High High
Biliary Cancer 1 79.96 Quite High
Carcinoma 1 76.08 Quite High
Apoptosis 6 60.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rac1 GTPase activation has been suggested to be critical for NADPH oxidase activation in immune cells and may have a similar role in the brain.
Regulation (critical) of Positive_regulation (activation) of Rac1 in brain
1) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 0.67 Pain Relevance 0.22
This new technique may also be used for the intrasphincteric injection of botulinum toxin in the treatment of achalasia, for the steroid injection treatment of refractory esophageal strictures, for celiac nerve block, for pseudocyst drainage, and for drug delivery into pancreatic tumors.
Regulation (used) of Positive_regulation (injection) of botulinum toxin in nerve associated with nerve block, pancreatic cancer and increased venous pressure under development
2) Confidence 0.36 Published 2000 Journal J. Gastroenterol. Section Abstract Doc Link 10777153 Disease Relevance 0.82 Pain Relevance 0.21

General Comments

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