INT8785

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Context Info
Confidence 0.75
First Reported 1992
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 5.55
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ALDH7A1) small molecule metabolic process (ALDH7A1) cytoplasm (ALDH7A1)
cytosol (ALDH7A1) oxidoreductase activity (ALDH7A1) nucleus (ALDH7A1)
Anatomy Link Frequency
skeletal muscles 2
enterocytes 1
smooth muscle 1
seminal vesicle 1
proximal 1
ALDH7A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Restless leg syndrome 13 96.40 Very High Very High Very High
chemokine 1 96.08 Very High Very High Very High
Inflammation 26 95.64 Very High Very High Very High
cytokine 6 92.96 High High
Central nervous system 3 92.88 High High
Inflammatory response 3 88.76 High High
metalloproteinase 2 84.60 Quite High
depression 5 84.16 Quite High
Dismenorea 1 83.36 Quite High
Nicotine 96 83.04 Quite High
Disease Link Frequency Relevance Heat
Injury 43 99.20 Very High Very High Very High
Stress Incontinence 44 98.68 Very High Very High Very High
Pulmonary Disease 5 96.76 Very High Very High Very High
Increased Venous Pressure Under Development 18 96.40 Very High Very High Very High
INFLAMMATION 29 95.64 Very High Very High Very High
Reprotox - General 2 61 95.48 Very High Very High Very High
Asthma 16 95.08 Very High Very High Very High
Peripheral Arterial Disease 3 94.48 High High
Premature Ejaculation 464 94.40 High High
Depression 5 84.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have determined the expression of phosphodiesterase (PDE) 7A1 and PDE7A2 in human cells that have been implicated in the pathogenesis of chronic obstructive pulmonary disease and asthma.
Spec (determined) Gene_expression (expression) of PDE associated with asthma and pulmonary disease
1) Confidence 0.75 Published 2003 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 12388353 Disease Relevance 0.19 Pain Relevance 0
However, enzymes of the PDE family are also expressed in various other tissues, including the brain.
Gene_expression (expressed) of PDE in brain
2) Confidence 0.75 Published 2005 Journal Int. J. Impot. Res. Section Abstract Doc Link 15674402 Disease Relevance 0.76 Pain Relevance 0.17
We have described five phosphodiesterase (PDE) isozymes that can be found in cardiac and vascular smooth muscle of animals and humans.
Gene_expression (found) of PDE in smooth muscle
3) Confidence 0.47 Published 1992 Journal Basic Res. Cardiol. Section Abstract Doc Link 1379794 Disease Relevance 0.13 Pain Relevance 0
A PDE surface is a parametric surface patch , defined as a function of two parameters u and v on a finite domain ?
Gene_expression (surface) of PDE
4) Confidence 0.30 Published 2005 Journal Theor Biol Med Model Section Body Doc Link PMC1198260 Disease Relevance 0.21 Pain Relevance 0
In the present context, this means that PDE surfaces can be made to adapt to changes in the shape of the limb and the associated wounds.

2 PDE Surfaces

Gene_expression (surfaces) of PDE in limb associated with injury
5) Confidence 0.30 Published 2005 Journal Theor Biol Med Model Section Body Doc Link PMC1198260 Disease Relevance 0.21 Pain Relevance 0
It is noteworthy that the process of PDE geometry generation from the scan data is currently carried out manually.
Gene_expression (generation) of PDE
6) Confidence 0.27 Published 2005 Journal Theor Biol Med Model Section Body Doc Link PMC1198260 Disease Relevance 0.28 Pain Relevance 0
We found that PDE4 family is the major cAMP-PDE expressed in human fetal membranes and that PDE4 activity is increased by LPS treatment.
Gene_expression (expressed) of PDE
7) Confidence 0.23 Published 2005 Journal J. Immunol. Section Abstract Doc Link 15944316 Disease Relevance 0.71 Pain Relevance 0.45
Effects of NO on PDE expression were analyzed at specific time intervals after continued DETA NONOate administration.
Gene_expression (expression) of PDE
8) Confidence 0.16 Published 2010 Journal Headache Section Body Doc Link 19751368 Disease Relevance 0 Pain Relevance 0
PDE expression in vas deferens has not been studied yet; however, nitrergic innervation and nitric oxide synthase (NOS) activity have been localized to the human vas deferens, seminal vesicle, prostate, urethra, and skeletal muscles (Dixon and Jen 1995; Jen and Dixon 1995; Hedlund et al 1997; Jen et al 1997).
Gene_expression (expression) of PDE in skeletal muscles associated with stress incontinence
9) Confidence 0.10 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936309 Disease Relevance 0.40 Pain Relevance 0.03
Further work is required to identify which PDE isoforms are expressed in small intestinal epithelial cells both along the proximal–distal and crypt–villus axes and which isoforms play a functional role in regulating solute transport at the brush-border membrane.
Gene_expression (expressed) of PDE in proximal
10) Confidence 0.09 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2428106 Disease Relevance 0.10 Pain Relevance 0
Studies reporting tissue distribution of PDE mRNA expression often include a small intestinal sample but generally it is not clear whether the PDE is expressed specifically in enterocytes.
Gene_expression (expressed) of PDE in enterocytes
11) Confidence 0.08 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2428106 Disease Relevance 0 Pain Relevance 0
Expression of PDE activity has been reported in the prostate, seminal vesicle, and skeletal muscles (Djoseland et al 1980; Stacey et al 1998; Yanaka et al 1998; Uckert et al 2001).
Gene_expression (Expression) of PDE in skeletal muscles
12) Confidence 0.08 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936309 Disease Relevance 0.57 Pain Relevance 0.08
NT-702 (parogrelil hydrochloride, NM-702), 4-bromo-6-[3-(4-chlorophenyl)propoxy]-5-[(pyridin-3-ylmethyl)amino]pyridazin-3(2H)-one hydrochloride, a novel phosphodiesterase (PDE) inhibitor synthesized as a potent vasodilatory and antiplatelet agent, is being developed for the treatment of intermittent claudication (IC) in patients with peripheral arterial disease.
Gene_expression (synthesized) of PDE associated with restless leg syndrome and peripheral arterial disease
13) Confidence 0.06 Published 2007 Journal Life Sci. Section Abstract Doc Link 17850826 Disease Relevance 0.63 Pain Relevance 0.56
However, PDE approximations in current use correspond to underlying axonal velocity distributions incompatible with experimental measurements.
Gene_expression (approximations) of PDE
14) Confidence 0.05 Published 2010 Journal PLoS Computational Biology Section Abstract Doc Link PMC2813262 Disease Relevance 0 Pain Relevance 0
When intracellular cAMP levels were directly raised with the adenylyl cylase activator forskolin, we observed effects similar to those of PDE-inhibitors.
Gene_expression (raised) of PDE
15) Confidence 0.04 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.39 Pain Relevance 0.51
PDE expression in vas deferens has not been studied yet; however, nitrergic innervation and nitric oxide synthase (NOS) activity have been localized to the human vas deferens, seminal vesicle, prostate, urethra, and skeletal muscles (Dixon and Jen 1995; Jen and Dixon 1995; Hedlund et al 1997; Jen et al 1997).
Gene_expression (expression) of PDE in urethra associated with stress incontinence
16) Confidence 0.03 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936309 Disease Relevance 0.40 Pain Relevance 0.03
Expression of PDE activity has been reported in the prostate, seminal vesicle, and skeletal muscles (Djoseland et al 1980; Stacey et al 1998; Yanaka et al 1998; Uckert et al 2001).
Gene_expression (Expression) of PDE in seminal vesicle
17) Confidence 0.03 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936309 Disease Relevance 0.57 Pain Relevance 0.08

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