INT87861

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2010
Negated 3
Speculated 5
Reported most in Abstract
Documents 33
Total Number 38
Disease Relevance 30.44
Pain Relevance 18.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il18) extracellular region (Il18) cytoplasm (Il18)
Anatomy Link Frequency
skin 3
macrophages 2
plasma 1
liver 1
microglia 1
Il18 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 95 100.00 Very High Very High Very High
Inflammation 83 100.00 Very High Very High Very High
cINOD 36 100.00 Very High Very High Very High
antagonist 13 100.00 Very High Very High Very High
Neuritis 25 99.88 Very High Very High Very High
Arthritis 56 99.84 Very High Very High Very High
spinal inflammation 4 99.84 Very High Very High Very High
Dorsal horn 2 99.68 Very High Very High Very High
spastic colon 93 99.08 Very High Very High Very High
Angina 38 98.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 118 100.00 Very High Very High Very High
Injury 38 100.00 Very High Very High Very High
Experimental Autoimmune Neuritis 25 99.88 Very High Very High Very High
Arthritis 55 99.84 Very High Very High Very High
Low Back Pain 4 99.84 Very High Very High Very High
Cancer 6 99.80 Very High Very High Very High
Obesity 11 99.70 Very High Very High Very High
Necrosis 6 99.56 Very High Very High Very High
Sarcoma 3 99.48 Very High Very High Very High
Nervous System Injury 8 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of the IL-18 mRNA and mature IL-18 protein in the gastric mucosa of AA rats administered indomethacin were also higher in comparison with normal rats receiving indomethacin.
Gene_expression (expression) of IL-18 protein associated with arthritis
1) Confidence 0.78 Published 2009 Journal Toxicology Section Abstract Doc Link 18996434 Disease Relevance 0.99 Pain Relevance 0.79
We demonstrate whether interleukin 18 (IL-18) expression relate the aggravation of gastric lesion in adjuvant-induced arthritis (AA) rats following the oral administration of indomethacin.
Spec (whether) Gene_expression (expression) of interleukin 18 associated with arthritis
2) Confidence 0.78 Published 2009 Journal Toxicology Section Abstract Doc Link 18996434 Disease Relevance 0.70 Pain Relevance 0.68
We demonstrate whether interleukin 18 (IL-18) expression relate the aggravation of gastric lesion in adjuvant-induced arthritis (AA) rats following the oral administration of indomethacin.
Spec (whether) Gene_expression (expression) of IL-18 associated with arthritis
3) Confidence 0.78 Published 2009 Journal Toxicology Section Abstract Doc Link 18996434 Disease Relevance 0.70 Pain Relevance 0.68
The expression of the IL-18 mRNA and mature IL-18 protein in the gastric mucosa of AA rats administered indomethacin were also higher in comparison with normal rats receiving indomethacin.
Gene_expression (expression) of IL-18 mRNA associated with arthritis
4) Confidence 0.78 Published 2009 Journal Toxicology Section Abstract Doc Link 18996434 Disease Relevance 0.98 Pain Relevance 0.79
It is possible that IL-18 expression in AA rats is more sensitive to indomethacin, and the IL-18 may play a role in the aggravation of gastric lesions in AA rats treated with indomethacin.
Gene_expression (expression) of IL-18 associated with arthritis
5) Confidence 0.78 Published 2009 Journal Toxicology Section Abstract Doc Link 18996434 Disease Relevance 0.86 Pain Relevance 0.50
The active form of IL-18 was highly expressed in injured arteries.
Gene_expression (expressed) of IL-18
6) Confidence 0.78 Published 2006 Journal Circulation Section Body Doc Link 16864728 Disease Relevance 0.09 Pain Relevance 0
Interleukin-18 (IL-18) is a potent IFN-gamma-inducing cytokine that is synthesized as an inactive precursor molecule and cleaved by caspase-1 into its mature active form.
Neg (inactive) Gene_expression (ynthesized ) of IL-18 associated with cytokine
7) Confidence 0.77 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11240039 Disease Relevance 1.09 Pain Relevance 0.57
Neutralization of interleukin-18 inhibits neointimal formation in a rat model of vascular injury.
Gene_expression (Neutralization) of interleukin-18 associated with vasculitis
8) Confidence 0.67 Published 2006 Journal Circulation Section Title Doc Link 16864728 Disease Relevance 0.45 Pain Relevance 0.09
Increased expression of IL-18 and IL-18Ralpha/beta mRNA was detectable in carotid arteries from days 2 to 14 after angioplasty.
Gene_expression (expression) of IL-18
9) Confidence 0.67 Published 2006 Journal Circulation Section Body Doc Link 16864728 Disease Relevance 0.09 Pain Relevance 0
Interleukin-18 (IL-18) is a potent IFN-gamma-inducing cytokine that is synthesized as an inactive precursor molecule and cleaved by caspase-1 into its mature active form.
Neg (inactive) Gene_expression (synthesized) of Interleukin-18 associated with cytokine
10) Confidence 0.67 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11240039 Disease Relevance 1.10 Pain Relevance 0.57
In our present study we analyzed the expression of IL-18 and caspase-1 in the nerve roots of EAN rats using reverse transcriptase-polymerase chain reaction and immunocytochemistry.
Spec (analyzed) Gene_expression (expression) of IL-18 in nerve associated with neuritis
11) Confidence 0.67 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11240039 Disease Relevance 1.18 Pain Relevance 0.62
Immunocytochemically, both perivascular and parenchymal IL-18 protein expression was increased in the roots of EAN rats and mainly associated with ED1+ macrophages stained on serial sections.
Gene_expression (expression) of IL-18 protein in macrophages associated with neuritis
12) Confidence 0.67 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11240039 Disease Relevance 1.38 Pain Relevance 0.69
Interleukin-18 (IL-18) is a potent IFN-gamma-inducing cytokine that is synthesized as an inactive precursor molecule and cleaved by caspase-1 into its mature active form.
Neg (inactive) Gene_expression (ynthesized ) of IFN-gamma-inducing associated with cytokine
13) Confidence 0.60 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11240039 Disease Relevance 1.09 Pain Relevance 0.57
Plasma levels of IL-18 were higher in the coronary artery disease group than in the risk control group (P = 0.062).
Gene_expression (levels) of IL-18 in coronary artery associated with coronary artery disease
14) Confidence 0.58 Published 2007 Journal Heart Vessels Section Abstract Doc Link 18043993 Disease Relevance 1.11 Pain Relevance 0.39
Long-lasting gene expression by particle-mediated intramuscular transfection modified with bupivacaine: combinatorial gene therapy with IL-12 and IL-18 cDNA against rat sarcoma at a distant site.
Gene_expression (expression) of IL-18 cDNA associated with sarcoma
15) Confidence 0.57 Published 2003 Journal Cancer Gene Ther. Section Title Doc Link 12679805 Disease Relevance 0.38 Pain Relevance 0.13
In patients with active MRI lesions the levels of IL-18 in CSF and serum were significantly higher in comparison with the levels found in patients without enhancing lesions.
Gene_expression (levels) of IL-18
16) Confidence 0.51 Published 2001 Journal Acta Neurol. Scand. Section Abstract Doc Link 11551238 Disease Relevance 0.26 Pain Relevance 0.16
Using this model we observed that: (1) inflammasome components and products NALP1, caspase-1, IL-1beta and IL-18 were present in low levels in normal skin, but expression of all these was strongly up-regulated after fracture, (2) NALP1, caspase-1 and IL-1beta were co-expressed in keratinocytes, and the number of NALP1, caspase-1, and IL-1beta positive cells dramatically increased at 4 weeks post-fracture, (3) LY303870, an NK1 receptor antagonist, effectively blocked fracture-induced up-regulation of activated inflammasome components and cytokines, (4) IL-1beta and IL-18 intraplantar injection induced mechanical allodynia in normal rats, and (5) both a selective caspase-1 inhibitor and an IL-1 receptor antagonist attenuated fracture-induced hindpaw mechanical allodynia.
Gene_expression (present) of IL-18 in skin associated with allodynia, antagonist and cytokine
17) Confidence 0.49 Published 2009 Journal Pain Section Abstract Doc Link 19853379 Disease Relevance 0.87 Pain Relevance 0.73
Using this model we observed that: (1) inflammasome components and products NALP1, caspase-1, IL-1beta and IL-18 were present in low levels in normal skin, but expression of all these was strongly up-regulated after fracture, (2) NALP1, caspase-1 and IL-1beta were co-expressed in keratinocytes, and the number of NALP1, caspase-1, and IL-1beta positive cells dramatically increased at 4 weeks post-fracture, (3) LY303870, an NK1 receptor antagonist, effectively blocked fracture-induced up-regulation of activated inflammasome components and cytokines, (4) IL-1beta and IL-18 intraplantar injection induced mechanical allodynia in normal rats, and (5) both a selective caspase-1 inhibitor and an IL-1 receptor antagonist attenuated fracture-induced hindpaw mechanical allodynia.
Gene_expression (antagonist) of IL-18 in skin associated with allodynia, antagonist and cytokine
18) Confidence 0.42 Published 2009 Journal Pain Section Abstract Doc Link 19853379 Disease Relevance 0.88 Pain Relevance 0.74
Using this model we observed that: (1) inflammasome components and products NALP1, caspase-1, IL-1beta and IL-18 were present in low levels in normal skin, but expression of all these was strongly up-regulated after fracture, (2) NALP1, caspase-1 and IL-1beta were co-expressed in keratinocytes, and the number of NALP1, caspase-1, and IL-1beta positive cells dramatically increased at 4 weeks post-fracture, (3) LY303870, an NK1 receptor antagonist, effectively blocked fracture-induced up-regulation of activated inflammasome components and cytokines, (4) IL-1beta and IL-18 intraplantar injection induced mechanical allodynia in normal rats, and (5) both a selective caspase-1 inhibitor and an IL-1 receptor antagonist attenuated fracture-induced hindpaw mechanical allodynia.
Gene_expression (components) of IL-18 in skin associated with allodynia, antagonist and cytokine
19) Confidence 0.42 Published 2009 Journal Pain Section Abstract Doc Link 19853379 Disease Relevance 0.88 Pain Relevance 0.74
Nerve injury induced a striking increase in IL-18 and IL-18R expression in the dorsal horn, and IL-18 and IL-18R were upregulated in hyperactive microglia and astrocytes, respectively.
Gene_expression (expression) of IL-18 in astrocytes associated with nervous system injury and dorsal horn
20) Confidence 0.31 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 19036970 Disease Relevance 0.68 Pain Relevance 0.51

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