INT87863

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2011
Negated 0
Speculated 2
Reported most in Abstract
Documents 40
Total Number 42
Disease Relevance 34.08
Pain Relevance 9.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL18) extracellular space (IL18) extracellular region (IL18)
cell-cell signaling (IL18) cytoplasm (IL18)
Anatomy Link Frequency
plaque 4
plasma 3
endothelial cells 3
macrophage 2
blood 2
IL18 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 513 100.00 Very High Very High Very High
cytokine 399 100.00 Very High Very High Very High
Pain 36 100.00 Very High Very High Very High
metalloproteinase 36 99.44 Very High Very High Very High
rheumatoid arthritis 608 99.34 Very High Very High Very High
Osteoarthritis 285 99.28 Very High Very High Very High
cINOD 29 95.84 Very High Very High Very High
substance P 5 94.96 High High
Inflammatory mediators 30 89.84 High High
Arthritis 3 88.92 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 637 100.00 Very High Very High Very High
Asthma 318 100.00 Very High Very High Very High
Necrosis 73 100.00 Very High Very High Very High
Cancer 63 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 191 99.84 Very High Very High Very High
Cv General 4 Under Development 21 99.84 Very High Very High Very High
Infection 54 99.78 Very High Very High Very High
Rheumatoid Arthritis 608 99.34 Very High Very High Very High
Sepsis 338 99.28 Very High Very High Very High
Osteoarthritis 221 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine the mechanism of accelerating IL-18 production, we examined the release of IL-18 in human endothelial cells using human recombinant (hr) C-reactive protein (CRP) as a stimulator of IL-18.
Positive_regulation (stimulator) of IL-18 in endothelial cells
1) Confidence 0.69 Published 2003 Journal Heart Vessels Section Abstract Doc Link 14520485 Disease Relevance 0.80 Pain Relevance 0.21
Our findings reveal the possibility that circulating CRP by itself could cause a deterioration of the inflammatory cascade in endothelial cells associated with the upregulation of IL-18.
Positive_regulation (upregulation) of IL-18 in endothelial cells associated with inflammation
2) Confidence 0.69 Published 2003 Journal Heart Vessels Section Abstract Doc Link 14520485 Disease Relevance 0.74 Pain Relevance 0.27
There was a significant elevation of IL-18 levels in pregnant sera from the first trimester until the onset of labour.
Positive_regulation (elevation) of IL-18
3) Confidence 0.66 Published 2000 Journal J. Reprod. Immunol. Section Abstract Doc Link 10779591 Disease Relevance 0.08 Pain Relevance 0
Once labour began, IL-18 levels increased further and remained until at least the third day of puerperium.
Positive_regulation (increased) of IL-18
4) Confidence 0.66 Published 2000 Journal J. Reprod. Immunol. Section Abstract Doc Link 10779591 Disease Relevance 0.09 Pain Relevance 0
IL-18 protein levels were increased in CP tissues compared to normal pancreatic tissues.
Positive_regulation (increased) of IL-18
5) Confidence 0.53 Published 2006 Journal World J. Gastroenterol. Section Body Doc Link 17072982 Disease Relevance 0 Pain Relevance 0
RESULTS: In patients, IL-18 serum levels were significantly enhanced by 76% (mean: 289.9+/-167.7 ng/L) compared with controls (mean: 165.2+/-43.6 ng/L; P<0.0005).
Positive_regulation (enhanced) of IL-18
6) Confidence 0.53 Published 2006 Journal World J. Gastroenterol. Section Body Doc Link 17072982 Disease Relevance 0 Pain Relevance 0
IL-18 in pregnancy; the elevation of IL-18 in maternal peripheral blood during labour and complicated pregnancies.
Positive_regulation (elevation) of IL-18 in blood associated with pain
7) Confidence 0.48 Published 2000 Journal J. Reprod. Immunol. Section Title Doc Link 10779591 Disease Relevance 0.08 Pain Relevance 0.20
IL-18 in pregnancy; the elevation of IL-18 in maternal peripheral blood during labour and complicated pregnancies.
Positive_regulation (elevation) of IL-18 in blood associated with pain
8) Confidence 0.48 Published 2000 Journal J. Reprod. Immunol. Section Title Doc Link 10779591 Disease Relevance 0.08 Pain Relevance 0.20
The high levels of IL-18 in sera were also observed in various complicated pregnancies, such as premature rupture of membranes (PROM), acute fatty liver of pregnancy and fetal growth restriction.
Positive_regulation (levels) of IL-18 in liver associated with fatty liver and rupture
9) Confidence 0.48 Published 2000 Journal J. Reprod. Immunol. Section Abstract Doc Link 10779591 Disease Relevance 0.19 Pain Relevance 0
Under certain conditions, however, stress hormones may actually facilitate inflammation through induction of interleukin (IL)-1, IL-6, IL-8, IL-18, tumor necrosis factor-alpha and C-reactive protein production and through activation of the corticotropin-releasing hormone/substance P-histamine axis.
Positive_regulation (induction) of IL-18 associated with stress, necrosis, inflammation, cancer and substance p
10) Confidence 0.47 Published 2005 Journal Neuroimmunomodulation Section Abstract Doc Link 16166805 Disease Relevance 2.89 Pain Relevance 0.83
However, the IL18 -607 allele A was significantly increased in GCA patients compared with controls (47.8% versus 40.9% in patients and controls respectively; P = 0.02; OR, 1.32; 95% CI, 1.04 to 1.69).
Positive_regulation (increased) of IL18 associated with increased venous pressure under development
11) Confidence 0.46 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2888200 Disease Relevance 0.71 Pain Relevance 0
Also, the IL18-1297 allele C was significantly increased in GCA patients (30.7%) compared with controls (23.0%) (P = 0.003; OR, 1.48; 95% CI, 1.13 to 1.95).
Positive_regulation (increased) of IL18 associated with increased venous pressure under development
12) Confidence 0.46 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2888200 Disease Relevance 0.82 Pain Relevance 0
Caspase-1, the IL-1beta converting enzyme (ICE), is required for intracellular processing/maturation of IL-1beta and IL-18.
Positive_regulation (processing/maturation) of IL-18
13) Confidence 0.41 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11046058 Disease Relevance 0.25 Pain Relevance 0.31
in response to IL-12 and IL-18 than those of healthy volunteers.
Positive_regulation (response) of IL-18
14) Confidence 0.41 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.50 Pain Relevance 0.33
production, total RA synovium cells showed a greater response to exogenous IL-18 in the presence of IL-12 than resting PBMCs.
Positive_regulation (response) of IL-18 in synovium associated with rheumatoid arthritis
15) Confidence 0.41 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.90 Pain Relevance 0.61
It was suggested that IL-18 in synergy with IL-12 and IL-15 could be involved in both Th1 immune responses and macrophage production of inflammatory cytokines such as TNF-?
Positive_regulation (involved) of IL-18 in macrophage associated with inflammation and cytokine
16) Confidence 0.41 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.45 Pain Relevance 0.31
In order to assess overall differences in systemic response to the Th1-inducing cytokines, IL-12 and IL-18, we compared the IFN-?
Positive_regulation (inducing) of IL-18 associated with cytokine
17) Confidence 0.41 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.67 Pain Relevance 0.42
production by these cells by neutralizing the endogenously produced IL-18, indicating the importance of endogenous IL-18 in IFN-?
Positive_regulation (importance) of IL-18
18) Confidence 0.41 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.98 Pain Relevance 0.51
production in response to IL-12 and IL-18 when compared with H-PBMCs.
Positive_regulation (response) of IL-18
19) Confidence 0.41 Published 2004 Journal Arthritis Res Ther Section Abstract Doc Link PMC400411 Disease Relevance 1.11 Pain Relevance 0.57
Plasma IL-18, a pro-inflammatory cytokine, is increased in patients with CKD, while its concentration is further raised by hemodialysis with bioincompatible membranes [20].
Positive_regulation (increased) of IL-18 in Plasma associated with chronic renal failure, inflammation and cytokine
20) Confidence 0.38 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2441592 Disease Relevance 0.63 Pain Relevance 0.14

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